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Innate Tumor Immune Surveillance

  • Conference paper
Crossroads between Innate and Adaptive Immunity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 590))

Abstract

The innate immune system is emerging as an important mediator of host response to tumor initiation, growth, and metastases. Several chemical carcinogenesis models in mice have implicated an important role for natural killer (NK) cells, γδ+ T cells, and a specialized CD1d-restricted population of T cells bearing NK cell receptors, called NKT cells1,2. The incidence of both methylcholanthrene (MCA)-induced fibrosarcoma and dimethylbenzanthracene (DMBA) and phorbol ester (TPA)-induced skin carcinomas is higher in mice lacking these vital innate immune cells. Furthermore, in allo-bone marrow transplantation (BMT), HLA class I disparities that induce NK cell alloreactions and GVHD also mediate strong graft-versus-leukemia (GVL) effects, producing higher engraftment rates and protecting patients from GVHD3,4. In murine MHC-mismatched transplant models with no donor T cell reactivity against the recipient, the pretransplant infusion of donor-vs.-recipient alloreactive NK cells obviated the need for high-intensity conditioning and conditioned the recipients to BMT without GVHD3,4. Several other studies also strongly support a key role for innate cells and mechanisms in controlling tumor initiation and growth5–8.

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Authors and Affiliations

  1. Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, 3002, Victoria, Australia

    Mark J. Smyth, Jeremy Swann & Yoshihiro Hayakawa

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  1. Mark J. Smyth
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  2. Jeremy Swann
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  3. Yoshihiro Hayakawa
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Editors and Affiliations

  1. Drexel University College of Medicine, Philadelphia, Pennsylvania, USA

    Peter D. Katsikis

  2. La Jolla Institute for Allergy and Immunology, La Jolla, California, USA

    Stephen P. Schoenberger

  3. Emory Vaccine Center, Emory University, Atlanta, Georgia, USA

    Bali Pulendran

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Smyth, M.J., Swann, J., Hayakawa, Y. (2007). Innate Tumor Immune Surveillance. In: Katsikis, P.D., Schoenberger, S.P., Pulendran, B. (eds) Crossroads between Innate and Adaptive Immunity. Advances in Experimental Medicine and Biology, vol 590. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-34814-8_7

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