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Endothelial and Hematopoietic Cells in the Intraembryonic Compartment

  • Chapter
Hematopoietic Stem Cell Development

Part of the book series: Medical Intelligence Unit ((MIUN))

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Abstract

The development of endothelial cells and hematopoietic cells is closely related at embryonic stages, and both cells share a common precursor, the hemangioblast. Differentiation into hematopoietic and endothelial lineages begins with proliferation of a single layer of mesodermal cells in the yolk sac resulting in formation of cell clusters, the blood islands. Cells at the periphery of these mesodermal aggregations differentiate into angioblasts. Blood vessels are formed by two different steps, vasculogenesis and angiogenesis. Cells in the interior of blood islands become primitive hematopoietic cells (HCs). Definitive hematopoiesis develops from the P-Sp region as early as E8.5. By El0.5, hematopoietic stem cells (HSCs) originate in the aorta-gonad-mesonephros (AGM) region. HSCs from this region colonize the fetal liver and then move to the spleen and bone marrow. In the embryo, HCs form clusters closely associated with and often adhering to endothelial cells on the ventral surface (floor) of the aorta. HCs that form these clusters also appear to be derived from the P-Sp. In addition, hematopoietic clusters have also been identified in the vitelline and umbilical arteries, indicating that intraembryonic hematopoietic development is associated with the major arterial region of the embryo.

Hematopoietic and endothelial lineages express several genes in common, such as VEGFR2, Tie2, and SCL/Tal-1. The fact that both lineages co-express common genes, many of which encode growth factor receptors or transcription factors, is not only consistent with the notion that they share a common precursor, but also suggests that similar molecular programs and growth regulatory mechanisms are involved in their development. Moreover, it has been reported that HSCs produce Angl, which promotes angiogenesis.

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  1. Department of Cell Differentiation The Sakaguchi Laboratory of Developmental Biology School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan

    Fumio Arai & Toshio Suda

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Arai, F., Suda, T. (2006). Endothelial and Hematopoietic Cells in the Intraembryonic Compartment. In: Hematopoietic Stem Cell Development. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-33535-3_8

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