Abstract
The adult hematopoietic system is composed of a number of different cell types, including erythrocytes and cells of the myeloid and lymphoid lineages. It is generally believed that all these cell types derive, through a series of maturing progenitors, from a common stem cell, which first appears during embryogenesis and persists into adult life. This hematopoietic stem cell (HSC) is defined by its ability to self-renew and to generate cells of all hematopoietic lineages. Clearly these cells would have enormous therapeutic potential in the treatment of blood disorders. However, because of the circulatory nature of the hematopoietic system and the multiple cell types involved, the processes controlling the generation and development of HSCs have proved difficult to study and are poorly understood.
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Marshall, C. (2006). Intraembryonic Development of Hematopoietic Stem Cells during Human Ontogeny: Expression Analysis. In: Hematopoietic Stem Cell Development. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-33535-3_11
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DOI: https://doi.org/10.1007/978-0-387-33535-3_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-306-47872-7
Online ISBN: 978-0-387-33535-3
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