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Hyperthermia and Radiotherapy in the Management of Prostate Cancer

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Hyperthermia in Cancer Treatment: A Primer

Part of the book series: Medical Intelligence Unit ((MIUN))

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Abstract

Carcinoma of the prostate has been included in the top five big killer neoplasms. The management of advanced disease is still a problem in oncology. Starting from the beginning of the eighties, hyperthermia has been associated to radiotherapy with the aim to increase the local control.

This issue summarizes the indication, technical modality and results of the combined treatment, both as radical and salvage therapy.

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References

  1. Algan O, Fosmire H, Hynynen K et al. External beam radiotherapy and hyperthermia in the treatment of patients with locally advanced prostate carcinoma. Cancer 2000; 89:399–403.

    Article  PubMed  CAS  Google Scholar 

  2. Anscher MS, Samulski TV, Leopold KA et al. Phase I/II study of external radio frequency phased array hyperthermia and external radiotherapy in the treatment of prostate cancer. Technique and results of intraprostatic temperature measurements. Int J Radiat Oncol Biol Phys 1992; 24:489–495.

    PubMed  CAS  Google Scholar 

  3. Anscher MS, Samulski TV, Dodge R et al. Combined external beam irradiation and external regional hyperthermia for locally advanced adenocarcinoma of the prostate. Int J Radiat Oncol Biol Phys 1997; 37(5):1059–1065.

    PubMed  CAS  Google Scholar 

  4. Astrahan MA, Ameye F, Oyen R et al. Interstitial temperature measurements during transurethral microwave hyperthermia. J Urol 1991; 145:304–308.

    PubMed  CAS  Google Scholar 

  5. Ben-Yosef R, Sullivan DM, Kapp DS. Peripheral neuropathy and myonecrosis following hyperthermia and radiation therapy for recurrent prostatic cancer: Correlation of damage with predicted SAR pattern. Int J Hyperthermia 1992; 8:173–185.

    Article  PubMed  CAS  Google Scholar 

  6. Bolla M, Collette L, Blank L et al. Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): A phase III randomized trial. Lancet 2002; 360:103–6.

    Article  PubMed  CAS  Google Scholar 

  7. Bray F, Sankila R, Ferlay J et al. Estimates of cancer incidence and mortality in Europe in 1995. Eur J Cancer 2002; 38:99–166.

    Article  PubMed  CAS  Google Scholar 

  8. Emami B, Scott C, Perez CA et al. Phase III study of interstitial thermotherapy compared with interstitial radiotherapy alone in the treatment of recurrent or persistent human tumors: A prospectively controlled randomized study by the Radiation Therapy Group. Int J Radiat Oncol Biol Phys 1996; 34:1097–1104.

    PubMed  CAS  Google Scholar 

  9. Fiveash JB, Hanks GE, Roach III M et al. 3D conformal radiation therapy (3DCRT) for high grade prostate cancer: A multi institutional review. Int J Radiat Oncol Biol Phys 2000; 47:335–342.

    Article  PubMed  CAS  Google Scholar 

  10. Fosmire H, Hynynen K, Drach GW et al. Feasibility and toxicity of transrectal ultrasound hyperthermia in the treatment of locally advanced adenocarcinoma of the prostate. Int J Radiat Oncol Biol Phys 1993; 26:253–259.

    PubMed  CAS  Google Scholar 

  11. Gottlieb CF, Seibert GB, Block NL. Interaction of irradiation and microwave-induced hyperthermia in the Dunning R3327G prostatic adenocarcinoma mode. Radiology 1988; 169:243–247.

    PubMed  CAS  Google Scholar 

  12. Hanks GE, Hanlon AL, Schultheiss TE et al. Dose escalation with 3D conformal treatment: Five years outcomes, treatment optimization, and future directions. Int J Radiat Oncol Biol Phys 1998; 4:501–510.

    Article  Google Scholar 

  13. Holaman M, Carlton Jr CE, Scardino PT. The frequency and morbidity of local tumor recurrence after definitive radiotherapy for stage C prostate cancer. J Urol 1991; 146:1578–1582.

    Google Scholar 

  14. Hurwitz MD, Kaplan ID, Svensson GK et al. Feasibility and patient tolerance of a novel transrectal ultrasound hyperthermia system for treatment of prostate cancer. Int J Hyperthermia 2001; 17:31–37.

    Article  PubMed  CAS  Google Scholar 

  15. Hurwitz MD, Kaplan I, Hansen JL et al. Association of rectal toxicity with thermal dose parameters in treatment of locally advanced prostate cancer with radiation and hyperthermia. Int J Radiat Oncol Biol Phys 2002; 53:913–918.

    Article  PubMed  Google Scholar 

  16. Kalapurakal JA, Mittal BB, Sathiaseelan V. Reirradiation and external hyperthermia in locally advanced, radiation recurrent, hormone refractory prostate cancer: A preliminary report. Br J Radiol 2001; 74:745–751.

    PubMed  CAS  Google Scholar 

  17. Kaplan ID, Cox RS, Bagshaw MA. Radiotherapy for prostate cancer: Patients selection and impact of local control. Urology 1994; 43:634–639.

    Article  PubMed  CAS  Google Scholar 

  18. Kaver I, Ware JL, Wilson JD et al. Effect of radiation combined with hyperthermia on human prostatic carcinoma cell lines in culture. Urology 1991; 38:88–92.

    Article  PubMed  CAS  Google Scholar 

  19. Krumholtz JS, Andriole GL. The surgery of prostate cancer: An update of contemporary radical prostatectomy and brachytherapy series. Semin Surg Oncol 1999; 17:213–218.

    Article  PubMed  CAS  Google Scholar 

  20. Kuban DA, El-Mahdi AM, Schellhammer PF. Potential benefit of improved local tumor control in patients with prostatic carcinoma. Cancer 1995; 75:2373–2381.

    Article  PubMed  CAS  Google Scholar 

  21. Lancaster C, Toi A, Trachtenberg J. Interstitial microwave thermoablation for localized prostate cancer. Urology 1999; 53:828–831.

    Article  PubMed  CAS  Google Scholar 

  22. Li WX, Franklin WA. Radiation-and heat-induced apoptosis in PC-3 prostate cancer cells. Radiat Res 1998; 150:190–194.

    Article  PubMed  CAS  Google Scholar 

  23. Mendecki J, Friedenthal E, Botstein C et al. Microwave applicators for localized hyperthermia treatment of cancer of the prostate. Int J Radiat Oncol Biol Phys 1980; 6:1583–1588.

    PubMed  CAS  Google Scholar 

  24. Myerson RJ, Scott CB, Emami B et al. Phase I/II study to evaluate radiation therapy and hyperthermia for deep seeped tumors: A report of RTOG 89-08. Int J Hypertherm 1996; 12:449–459.

    Article  CAS  Google Scholar 

  25. Parker CC, Dearnaley DP. The management of PSA failure after radiotherapy for localized prostate cancer. Radiother Oncol 1998; 49:103–110.

    Article  PubMed  CAS  Google Scholar 

  26. Peschke P, Hahn EW, Wenz F et al. Differential sensitivity of three sublines of the rat dunning prostate tumor system R3327 to radiation and/or local tumor hyperthermia. Radiat Res 1998; 150:423–430.

    Article  PubMed  CAS  Google Scholar 

  27. Pienta KJ, Redman B, Hussain M et al. Phase II evaluation of oral estramustine and oral etoposide in hormone refractory adenocarcinoma of the prostate. J Clin Oncol 1994; 12:2005–2012.

    PubMed  CAS  Google Scholar 

  28. Pollack A, Zagars GK, Starkschall G et al. Prostate cancer radiation dose response: Results of the M.D. Anderson Phase III randomized trial. Int J Radiat Oncol Biol Phys 2002; 53:1097–1105.

    Article  PubMed  Google Scholar 

  29. Potosky AL, Miller BA, Albertsen PC et al. The role of increasing detection in the rising incidence of prostate cancer. JAMA 1995; 273(7):548–552.

    Article  PubMed  CAS  Google Scholar 

  30. Prionas SD, Kapp DS, Goffinet DR et al. Thermometry of interstitial hyperthermia given as an adjuvant to brachytherapy for the treatment of carcinoma of the prostate. Int J Radiat Oncol Biol Phys 1994; 28(1):151–162.

    PubMed  CAS  Google Scholar 

  31. Prostate Cancer Trialists’s Collaborative Group. Maximum androgen blokade in advanced prostate cancer: An overview of randomised trials. Lancet 2000; 355:1491–1498.

    Article  Google Scholar 

  32. Ryu S, Brown SL, Kim SH et al. Preferential radiosensitization of human prostatic carcinoma cells by mild hyperthermia. Int J Radiat Oncol Biol Phys 1996; 34:133–138.

    PubMed  CAS  Google Scholar 

  33. Sandier HM, Dunn RL, McLaughlin PW et al. Overall survival after prostate-specific-antigen-detected recurrence following conformal radiation-therapy. Int J Radiat Oncol Biol Phys 2000; 48:629–633.

    Google Scholar 

  34. Scheiblich J, Petrowicz O. Radiofrequency-induced hyperthermia in the prostate. J Microw Power 1982; 17:203–209.

    PubMed  CAS  Google Scholar 

  35. Servadio C, Leib Z. Hyperthermia in the treatment of prostate cancer. Prostate 1984; 5:205–211.

    Article  PubMed  CAS  Google Scholar 

  36. Sherar MD, Gertner MR, Clarence KK et al. Interstitial microwave thermal therapy for prostate cancer: Method of treatment and results of a phase I/II trial. J Urol 2001; 166:1707–1714.

    Article  PubMed  CAS  Google Scholar 

  37. Shipley WU, Thames H, Sandier HM et al. Radiation therapy for clinically localized prostate cancer: A multi-institutional pooled analysis. JAMA 199; 281:1598–1604.

    Google Scholar 

  38. Stawarz B, Zielinski H, Szmigielski S et al. Transrectal hyperthermia as palliative treatment for advanced adenocarcinoma of prostate and studies of cell-mediated immunity. Urology 1993; 41:548–553.

    Article  PubMed  CAS  Google Scholar 

  39. Strohmaier WL, Bichler RH, Bocking A et al. Histological effects of local microwave hyperthermia in prostatic cancer. Int J Hyperthermia 1991; 7:27–33.

    Article  PubMed  CAS  Google Scholar 

  40. Tucker RD, Platz CE, Huidobro C et al. Interstitial thermal therapy in patients with localized prostate cancer: Histologic analysis. Urology 2002; 60:166–169.

    Article  PubMed  Google Scholar 

  41. Venn SN, Hughes SW, Montgomery BSI et al. Heating characteristics of a 434 MHz transurethral system for the treatment of BPH and interstitial thermometry. Int J Hyperthermia 1996; 12:271–278.

    Article  PubMed  CAS  Google Scholar 

  42. van Vulpen M, Raaymakers BW, Lagendijk JJW et al. Three-dimensional controlled interstitial hyperthermia combined with radiotherapy for locally advanced prostate carcinoma. A feasibility study. Int J Radiat Oncol Biol Phys 2002; 53:116–126.

    PubMed  Google Scholar 

  43. Yerushalmi A, Servadio C, Leib Z et al. Local hyperthermia for treatment of carcinoma of the prostate: A preliminary report. Prostate 1982; 3:623–630.

    Article  PubMed  CAS  Google Scholar 

  44. Yerushalmi A, Shani A, Fishelovitz Y et al. Local microwave hyperthermia in the treatment of carcinoma of the prostate. Oncology 1986; 43:299–305.

    Article  PubMed  CAS  Google Scholar 

  45. Zagars GK, Pollack A, Smith LG. Conventional external beam radiation therapy alone or with androgen ablation for clinical stage III (T3,NX/0,M0) adenocarcinoma of the prostate. Int J Radiat Oncol Biol Phys 1999; 44:809–819.

    PubMed  CAS  Google Scholar 

  46. Zelefsky MJ, Leibel SA, Gaudin PB et al. Dose escalation with tree-dimensional conformal radiation therapy affects the outcome in prostate cancer. Int J Radiat Oncol Biol Phys 1998; 491–500.

    Google Scholar 

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© 2006 Landes Bioscience and Springer Science+Business Media

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Villa, S. (2006). Hyperthermia and Radiotherapy in the Management of Prostate Cancer. In: Hyperthermia in Cancer Treatment: A Primer. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-33441-7_13

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