1. Summary
The complex formed by the synaptic cell adhesion molecules neuroligin and β-neurexin has been implicated in synaptogenesis due to the molecular asymmetry of their heterophilic binding, reflecting the asymmetric nature of the synapse. During the past 5 years, their role in synapse formation has been explored in vitro, yielding exciting, though sometimes conflicting results. In this chapter, we focus on the biochemical and functional aspects of the neuroligin/β-neurexin complex, with an emphasis on the recent contributions coming from various cell culture approaches. In addition, we point out important unresolved issues with respect to their binding properties, their proposed function at excitatory versus inhibitory synapses, and their putative involvement in psychiatric diseases such as autism spectrum disorders.
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Fairless, R., Reissner, C., Missler, M. (2006). Role of Neuroligin Binding to Neurexins in Synaptic Organization. In: Dityatev, A., El-Husseini, A. (eds) Molecular Mechanisms of Synaptogenesis. Springer, Boston, MA . https://doi.org/10.1007/978-0-387-32562-0_8
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DOI: https://doi.org/10.1007/978-0-387-32562-0_8
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