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Oscillatory Expression of Hes Family Transcription Factors: Insights from Mathematical Modelling

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Cellular Oscillatory Mechanisms

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 641))

Abstract

Oscillatory expression of the Hes family of transcription factors plays a central role in the segmentation of the vertebrate body during embryonic development. Analogous oscillations in cultured cells suggest that Hes oscillations may be important in other developmental processes, and provide an excellent opportunity to explore the origin of these oscillations in a relatively simple setting. Mathematical and computational modelling have been used in combination with quantitative mRNA and protein expression data to analyse the origin and properties of Hes oscillations, and have highlighted the important roles played by time delays in negative feedback circuits. In this chapter, we review recent theoretical and experimental results, and discuss how analysis of existing models suggests potential avenues for further study of delayed feedback oscillators.

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Author information

Authors and Affiliations

  1. Department of Computer Science, University of Sheffield, Sheffield, UK

    Hiroshi Momiji

  2. Monk-School of Mathematical Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK

    Nicholas A.M. Monk

Authors
  1. Hiroshi Momiji
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  2. Nicholas A.M. Monk
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Editor information

Editors and Affiliations

  1. College of Life Sciences, University of Dundee, Dundee, Scotland, UK

    Miguel Maroto

  2. School of Mathematical Sciences, University of Nottingham, Nottingham, UK

    Nicholas A. M. Monk

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© 2008 Landes Bioscience and Springer Science+Business Media

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Momiji, H., Monk, N.A. (2008). Oscillatory Expression of Hes Family Transcription Factors: Insights from Mathematical Modelling. In: Maroto, M., Monk, N.A.M. (eds) Cellular Oscillatory Mechanisms. Advances in Experimental Medicine and Biology, vol 641. Springer, New York, NY. https://doi.org/10.1007/978-0-387-09794-7_6

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