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Human Brain-Dead Donors and 31P MRS Studies on Feline Myocardial Energy Metabolism

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Brain Death and Disorders of Consciousness

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 550))

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Abstract

In clinical heart transplantation, the heart of a brain dead donor is used. The quality of the donor heart is one of the key factors for a succesful transplantation. A hemodynamically unstable brain dead donor is often rejected because survival of the recipient is reduced.1–3 The precise mechanisms of brain death-related hemodynamic instability remain unknown. One of the reported contributing factors is myocardial injury resulting from the acutely increased discharge of endogenous catecholamines during the onset of brain death.4,5 This injury has been supposed to change aerobic to anaerobic energy metabolism, causing depletion of myocardial high-energy phosphates and contractile dysfunction.6–8 Energy depletion appeared to be even more pronounced when high dosages of inotropic agents were used to treat contractile dysfunction of the canine donor heart.9 Notwithstanding these results, the presence of anaerobic metabolism is disputed by others.10-13

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Author information

Authors and Affiliations

  1. Department of Cardiothoracic Surgery, Isala Clinics, Groot Wezenland 20, 8011 JW, Zwolle, The Netherlands

    George J. Brandon Bravo Bruinsma M.D., Ph.D. (Cardiothoracic Surgeon)

  2. Heart Lung Center Utrecht, CardioNMR Laboratory, University Medical Center Utrecht, The Netherlands

    Cees J. A. van Echteld Ph.D ., F.E.S.C.

Authors
  1. George J. Brandon Bravo Bruinsma M.D., Ph.D.
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  2. Cees J. A. van Echteld Ph.D ., F.E.S.C.
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Editor information

Editors and Affiliations

  1. Institute of Neurology and Neurosurgery, Havana, Cuba

    Calixto Machado

  2. David Geffen School of Medicine at UCLA, Los Angeles, California, USA

    D. Alan Shewmon

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Bruinsma, G.J.B.B., van Echteld, C.J.A. (2004). Human Brain-Dead Donors and 31P MRS Studies on Feline Myocardial Energy Metabolism. In: Machado, C., Shewmon, D.A. (eds) Brain Death and Disorders of Consciousness. Advances in Experimental Medicine and Biology, vol 550. Springer, Boston, MA. https://doi.org/10.1007/978-0-306-48526-8_18

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  • DOI: https://doi.org/10.1007/978-0-306-48526-8_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0976-6

  • Online ISBN: 978-0-306-48526-8

  • eBook Packages: Springer Book Archive

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