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Homocysteine and Erythrocyte Sedimentation Rate Correlate with Cerebrovascular Disease in Fabry Disease

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JIMD Reports - Case and Research Reports, 2012/3

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References

  • Aerts JM, Groener JE, Kuiper S et al (2008) Elevated globotriaosylsphingosine is a hallmark of Fabry disease. Proc Natl Acad Sci USA 105(8):2812–2817

    Article  PubMed  CAS  Google Scholar 

  • Altarescu G, Chicco G, Whybra C et al (2008) Correlation between interleukin-6 promoter and C-reactive protein (CRP) polymorphisms and CRP levels with the Mainz Severity Score Index for Fabry disease. J Inherit Metab Dis 31(1):117–123

    Article  PubMed  CAS  Google Scholar 

  • Baptista MV, Ferreira S, Pinho EMT et al (2010) Mutations of the GLA gene in young patients with stroke: the PORTYSTROKE study–screening genetic conditions in Portuguese young stroke patients. Stroke 41(3):431–436

    Article  PubMed  CAS  Google Scholar 

  • Beck M (2006) Demographics of FOS – the Fabry Outcome Survey. In: Beck M, Mehta A, Sunder-Plassmann G (eds) Fabry disease: perspectives from 5 years of FOS. Oxford PharmaGenesis, Oxford

    Google Scholar 

  • Brouns R, Thijs V, Eyskens F et al (2010) Belgian Fabry study: prevalence of Fabry disease in a cohort of 1000 young patients with cerebrovascular disease. Stroke 41(5):863–868

    Article  PubMed  Google Scholar 

  • Chamorro A, Vila N, Ascaso C et al (1995) Early prediction of stroke severity. Role of the erythrocyte sedimentation rate. Stroke 26(4):573–576

    Article  PubMed  CAS  Google Scholar 

  • Demuth K, Germain DP (2002) Endothelial markers and homocysteine in patients with classic Fabry disease. Acta Paediatr Suppl 91(439):57–61

    Article  PubMed  CAS  Google Scholar 

  • Fedi S, Gensini F, Gori AM et al (2005) Homocysteine and tissue factor pathway inhibitor levels in patients with Fabry's disease. J Thromb Haemost 3(9):2117–2119

    Article  PubMed  CAS  Google Scholar 

  • Friedman AN, Bostom AG, Selhub J et al (2001) The kidney and homocysteine metabolism. J Am Soc Nephrol 12(10):2181–2189

    PubMed  CAS  Google Scholar 

  • Ginsberg L, Manara R, Valentine AR et al (2006) Magnetic resonance imaging changes in Fabry disease. Acta Paediatr Suppl 95(451):57–62

    Article  PubMed  Google Scholar 

  • Hankey GJ, Eikelboom JW (2005) Homocysteine and stroke. Lancet 365(9455):194–196

    PubMed  Google Scholar 

  • Lee M, Hong KS, Chang SC et al (2010) Efficacy of homocysteine-lowering therapy with folic Acid in stroke prevention: a meta-analysis. Stroke 41(6):1205–1212

    Article  PubMed  CAS  Google Scholar 

  • Mehta A, Ginsberg L (2005) Natural history of the cerebrovascular complications of Fabry disease. Acta Paediatr Suppl 94(447):24–27, discussion 29–10

    Article  PubMed  CAS  Google Scholar 

  • Mehta A, Beck M, Eyskens F et al (2010) Fabry disease: a review of current management strategies. QJM 103(9):641–659

    Article  PubMed  CAS  Google Scholar 

  • Miller ER 3rd, Juraschek S, Pastor-Barriuso R et al (2010) Meta-analysis of folic acid supplementation trials on risk of cardiovascular disease and risk interaction with baseline homocysteine levels. Am J Cardiol 106(4):517–527

    Article  PubMed  Google Scholar 

  • Moore DF, Altarescu G, Barker WC et al (2003) White matter lesions in Fabry disease occur in 'prior' selectively hypometabolic and hyperperfused brain regions. Brain Res Bull 62(3):231–240

    Article  PubMed  CAS  Google Scholar 

  • Rolfs A, Bottcher T, Zschiesche M et al (2005) Prevalence of Fabry disease in patients with cryptogenic stroke: a prospective study. Lancet 366(9499):1794–1796

    Article  PubMed  Google Scholar 

  • Shu L, Park JL, Byun J et al (2009) Decreased nitric oxide bioavailability in a mouse model of Fabry disease. J Am Soc Nephrol 20(9):1975–1985

    Article  PubMed  CAS  Google Scholar 

  • Swartz JE, Jacobson BF, Connor MD et al (2005) Erythrocyte sedimentation rate as a marker of inflammation and ongoing coagulation in stroke and transient ischaemic attack. S Afr Med J 95(8):607–612

    PubMed  CAS  Google Scholar 

  • Testai FD, Gorelick PB (2010) Inherited metabolic disorders and stroke part 1: Fabry disease and mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes. Arch Neurol 67(1):19–24

    Article  PubMed  Google Scholar 

  • Vedder AC, Biro E, Aerts JM et al (2009) Plasma markers of coagulation and endothelial activation in Fabry disease: impact of renal impairment. Nephrol Dial Transplant 24(10):3074–3081

    Article  PubMed  CAS  Google Scholar 

  • Wozniak MA, Kittner SJ, Tuhrim S et al (2010) Frequency of unrecognized Fabry disease among young European-American and African-American men with first ischemic stroke. Stroke 41(1):78–81

    Article  PubMed  Google Scholar 

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Authors and Affiliations

Authors

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Correspondence to M. C. Tchan .

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Additional information

Communicated by: Verena Peters

Appendices

Author Contributions

Ron Cheung . Wrote the initial draft article and performed statistical analyses.

David Sillence. Revised the draft article and supervised enzyme replacement therapy.

Michel Tchan. Designed the study and revised the draft article. Supervised enzyme replacement therapy. Guarantor.

Competing Interest Statement

Dr Tchan reports having received reimbursement from Genzyme Corporation for travel expenses to attend educational meetings.

Details of Funding

No funding was obtained for this study.

Ethics Approval and Patient Consent

Ethics approval was obtained from the human research ethics committee of the Children’s Hospital at Westmead (project MR 2009-06-15). Written, informed consent was taken from all participants.

Synopsis

Elevated homocysteine concentrations and ESR are independent risk factors for CVD in Fabry disease.

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© 2012 SSIEM and Springer-Verlag Berlin Heidelberg

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Cheung, R., Sillence, D.O., Tchan, M.C. (2012). Homocysteine and Erythrocyte Sedimentation Rate Correlate with Cerebrovascular Disease in Fabry Disease. In: JIMD Reports - Case and Research Reports, 2012/3. JIMD Reports, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8904_2011_123

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  • DOI: https://doi.org/10.1007/8904_2011_123

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-28128-0

  • Online ISBN: 978-3-642-28129-7

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