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Host Signal Transduction and Protein Kinases Implicated in Legionella Infection

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Molecular Mechanisms in Legionella Pathogenesis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 376))

Abstract

Modulation of the phosphorylation status of proteins by both kinases and phosphatases plays an important role in cellular signal transduction. Challenge of host cells by Legionella pneumophila manipulates the phosphorylation state of multiple host factors. These changes play roles in bacterial uptake, vacuole modification, cellular survival, and the immune response. In addition to modification by host cell kinases in response to the bacterium, L. pneumophila translocates bacterial kinases into the host cell that may contribute to further signaling modifications. Proper regulation of host cell signaling by L. pneumophila is necessary for its ability to replicate intracellulary, while avoiding host defenses.

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Abbreviations

BMDMs:

Bone marrow-derived macrophages

CAPE:

Caffeic acid phenethyl ester

CR3:

Complement receptor 3

DAG:

Diacylglycerol

Dusp:

Dual-specificity protein phosphatase

hBD-2:

Human β-defensin-2

IDTS:

Icm/Dot translocated substrates

IκB:

Inhibitor of κB

Icm/Dot:

Intracellular multiplication/defect in organelle trafficking

IKK:

IκB kinase

LCV:

Legionella-containing vacuole

LF:

Lethal factor

MAPKK:

MAPK kinase

MAPKKK:

MAPK kinase kinase

MAPK:

Mitogen-activated protein kinase

NF-κB:

Nuclear factor kappa-light-chain-enhancer of activated B cells

NLR:

Nucleotide-binding oligomerization domain like receptor

PAMP:

Pathogen-associated molecular pattern

PRR:

Pattern recognition receptor

PI3K:

Phosphoinositide 3-kinase

PGE2 :

Prostaglandin E2

PKB/Akt:

Protein kinase B

PKC:

Protein kinase C

TLR:

Toll-like receptor

T4SS:

Type IV secretion system

TPK:

Tyrosine protein kinase

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Authors and Affiliations

  1. Howard Hughes Medical Institute, Tufts University School of Medicine, Boston, MA, 02111, USA

    Ralph R. Isberg

  2. Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, 02111, USA

    Andrew D. Hempstead & Ralph R. Isberg

  3. Graduate Program in Molecular Microbiology, Sackler School of Graduate Biomedical Science, Tufts University School of Medicine, Boston, MA, 02111, USA

    Andrew D. Hempstead

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  1. Andrew D. Hempstead
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  2. Ralph R. Isberg
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Correspondence to Ralph R. Isberg .

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  1. Max von Pettenkofer Institute, Ludwig-Maximilians University München, Munich, Germany

    Hubert Hilbi

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Hempstead, A.D., Isberg, R.R. (2013). Host Signal Transduction and Protein Kinases Implicated in Legionella Infection. In: Hilbi, H. (eds) Molecular Mechanisms in Legionella Pathogenesis. Current Topics in Microbiology and Immunology, vol 376. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2013_342

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