Skip to main content
SpringerLink
Log in

Passive Immunization with Allergen-Specific Antibodies

  • Chapter
  • First Online:
Vaccines against Allergies

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 352))

Abstract

The induction of allergen-specific IgG antibodies has been identified as a major mechanism responsible for the reduction of allergic inflammation in allergic patients treated by allergen-specific immunotherapy. Several studies suggest that allergen-specific IgG antibodies induced by vaccination with allergens block mast cell and basophil degranulation, IgE-facilitated allergen presentation to T cells and IgE production. The availability of recombinant allergens and technologies for the production of recombinant human antibodies allows engineering of allergen-specific antibodies which can be used for passive immunization (i.e., therapy) and eventually for the prevention of allergy (i.e., prophylaxis). This chapter summarizes data supporting the possible use of allergen-specific antibodies for treatment and prophylaxis. Finally, concrete approaches for the treatment and prevention of allergy based on blocking antibodies are envisioned.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

SIT:

Specific immunotherapy

APC:

Antigen presenting cell

FcεRI:

High-affinity IgE receptor

scFv:

Single-chain antibody fragment

Fab:

Antibody fragment

FcγR:

IgG Fc receptor

FcRn:

Neonatal Fc receptor

BAL:

Broncho alveolar lavage

AHR:

Airway hyper-responsiveness

OVA:

Ovalbumin

i.v.:

Intravenous

i.p.:

Intraperitoneal

s.c.:

Subcutaneous

SPR:

Surface plasmon resonance

ADCC:

Antibody dependent cell-mediated cytotoxicity

References

  • Aalberse RC, van der Gaag R, van Leeuwen J (1983) Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response. J Immunol 130(2):722–726

    CAS  PubMed  Google Scholar 

  • Akilesh S, Christianson GJ, Roopenian DC, Shaw AS (2007) Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism. J Immunol 179(7):4580–4588

    CAS  PubMed  Google Scholar 

  • Allen LC, Kepley CL, Saxon A, Zhang K (2007) Modifications to an Fcgamma-Fcvarepsilon fusion protein alter its effectiveness in the inhibition of FcvarepsilonRI-mediated functions. J Allergy Clin Immunol 120(2):462–468

    Article  CAS  PubMed  Google Scholar 

  • Bernstein IL, Michael JG, Malkiel S, Sweet LC, Brackett RG (1979) Immunoregulatory function of specific IgG. II. Clinical evaluation of combined active and passive immunotherapy. Int Arch Allergy Appl Immunol 58(1):30–37

    Article  CAS  PubMed  Google Scholar 

  • Birkner T, Rumpold H, Jarolim E, Ebner H, Breitenbach M, Skvaril F, Scheiner O, Kraft D (1990) Evaluation of immunotherapy-induced changes in specific IgE, IgG and IgG subclasses in birch pollen allergic patients by means of immunoblotting. Correlation with clinical response. Allergy 45(6):418–426

    Article  CAS  PubMed  Google Scholar 

  • Bodtger U, Ejrnaes AM, Hummelshoj L, Jacobi HH, Poulsen LK, Svenson M (2005) Is immunotherapy-induced birch-pollen-specific IgG4 a marker for decreased allergen-specific sensitivity? Int Arch Allergy Immunol 136(4):340–346

    Article  CAS  PubMed  Google Scholar 

  • Bousquet J, Fontez A, Aznar R, Robinet-Levy M, Michel FB (1987) Combination of passive and active immunization in honeybee venom immunotherapy. J Allergy Clin Immunol 79(6):947–954

    Article  CAS  PubMed  Google Scholar 

  • Cady CT, Powell MS, Harbeck RJ, Giclas PC, Murphy JR, Katial RK, Weber RW, Hogarth PM, Johnson S, Bonvini E, Koenig S, Cambier JC (2010) IgG antibodies produced during subcutaneous allergen immunotherapy mediate inhibition of basophil activation via a mechanism involving both FcgammaRIIA and FcgammaRIIB. Immunol Lett 130(1–2):57–65

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Chapman AP, Antoniw P, Spitali M, West S, Stephens S, King DJ (1999) Therapeutic antibody fragments with prolonged in vivo half-lives. Nat Biotechnol 17(8):780–783

    Article  CAS  PubMed  Google Scholar 

  • Christensen PA, Danielczyk A, Ravn P, Larsen M, Stahn R, Karsten U, Goletz S (2009) Modifying antibody specificity by chain shuffling of V/V between antibodies with related specificities. Scand J Immunol 69(1):1–10

    Article  CAS  PubMed  Google Scholar 

  • Constantinou A, Chen C, Deonarain MP (2010) Modulating the pharmacokinetics of therapeutic antibodies. Biotechnol Lett 32(5):609–622

    Article  CAS  PubMed  Google Scholar 

  • Cooke R (1935) Serological evidence of immunity with coexisting sensitization in hay fever type of humanallergy. J Exp Med 62:733–750

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Corren J, Busse W, Meltzer EO, Mansfield L, Bensch G, Fahrenholz J, Wenzel SE, Chon Y, Dunn M, Weng HH, Lin SL (2010) A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma. Am J Respir Crit Care Med 181(8):788–796

    Article  CAS  PubMed  Google Scholar 

  • Creticos PS, Schroeder JT, Hamilton RG, Balcer-Whaley SL, Khattignavong AP, Lindblad R, Li H, Coffman R, Seyfert V, Eiden JJ, Broide D (2006) Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis. N Engl J Med 355(14):1445–1455

    Article  CAS  PubMed  Google Scholar 

  • Denepoux S, Eibensteiner PB, Steinberger P, Vrtala S, Visco V, Weyer A, Kraft D, Banchereau J, Valenta R, Lebecque S (2000) Molecular characterization of human IgG monoclonal antibodies specific for the major birch pollen allergen Bet v 1. Anti-allergen IgG can enhance the anaphylactic reaction. FEBS Lett 465(1):39–46

    Article  CAS  PubMed  Google Scholar 

  • Djurup R, Malling HJ (1987) High IgG4 antibody level is associated with failure of immunotherapy with inhalant allergens. Clin Allergy 17(5):459–468

    Article  CAS  PubMed  Google Scholar 

  • Ejrnaes AM, Bodtger U, Larsen JN, Svenson M (2004) The blocking activity of birch pollen-specific immunotherapy-induced IgG4 is not qualitatively superior to that of other IgG subclasses. Mol Immunol 41(5):471–478

    Article  CAS  PubMed  Google Scholar 

  • Ejrnaes AM, Svenson M, Lund G, Larsen JN, Jacobi H (2006) Inhibition of rBet v 1-induced basophil histamine release with specific immunotherapy -induced serum immunoglobulin G: no evidence that FcgammaRIIB signalling is important. Clin Exp Allergy 36(3):273–282

    Article  CAS  PubMed  Google Scholar 

  • Finlay WJ, Cunningham O, Lambert MA, Darmanin-Sheehan A, Liu X, Fennell BJ, Mahon CM, Cummins E, Wade JM, O’Sullivan CM, Tan XY, Piche N, Pittman DD, Paulsen J, Tchistiakova L, Kodangattil S, Gill D, Hufton SE (2009) Affinity maturation of a humanized rat antibody for anti-RAGE therapy: comprehensive mutagenesis reveals a high level of mutational plasticity both inside and outside the complementarity-determining regions. J Mol Biol 388(3):541–558

    Article  CAS  PubMed  Google Scholar 

  • Flicker S, Valenta R (2003) Renaissance of the blocking antibody concept in type I allergy. Int Arch Allergy Immunol 132(1):13–24

    Article  CAS  PubMed  Google Scholar 

  • Flicker S, Vrtala S, Steinberger P, Vangelista L, Bufe A, Petersen A, Ghannadan M, Sperr WR, Valent P, Norderhaug L, Bohle B, Stockinger H, Suphioglu C, Ong EK, Kraft D, Valenta R (2000) A human monoclonal IgE antibody defines a highly allergenic fragment of the major timothy grass pollen allergen, Phl p 5: molecular, immunological, and structural characterization of the epitope-containing domain. J Immunol 165(7):3849–3859

    CAS  PubMed  Google Scholar 

  • Flicker S, Steinberger P, Norderhaug L, Sperr WR, Majlesi Y, Valent P, Kraft D, Valenta R (2002) Conversion of grass pollen allergen-specific human IgE into a protective IgG(1) antibody. Eur J Immunol 32(8):2156–2162

    Article  CAS  PubMed  Google Scholar 

  • Flicker S, Steinberger P, Ball T, Krauth MT, Verdino P, Valent P, Almo S, Valenta R (2006) Spatial clustering of the IgE epitopes on the major timothy grass pollen allergen Phl p 1: importance for allergenic activity. J Allergy Clin Immunol 117(6):1336–1343

    Article  CAS  PubMed  Google Scholar 

  • Flicker S, Steinberger P, Eibensteiner PB, Lebecque S, Kraft D, Valenta R (2008) Molecular characterization of a human immunoglobulin G4 antibody specific for the major birch pollen allergen, Bet v 1. Clin Exp Allergy 38 (2):365–373

    Article  CAS  PubMed  Google Scholar 

  • Flicker S, Marth K, Kofler H, Valenta R (2009) Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy-treated mother. J Allergy Clin Immunol 124(6):1358–1360 e1

    Article  CAS  PubMed  Google Scholar 

  • Gadermaier E, Flicker S, Aberer W, Egger C, Reider N, Focke M, Vrtala S, Kundi M, Valenta R (2010a) Analysis of the antibody responses induced by subcutaneous injection immunotherapy with birch and Fagales pollen extracts adsorbed onto aluminum hydroxide. Int Arch Allergy Immunol 151(1):17–27

    Article  CAS  Google Scholar 

  • Gadermaier E, Flicker S, Steinberger P, Valenta R (2010b) Evidence that the heavy-chain determines the specificity of IgE antibodies in allergy. 14th international congress of immunology, Kansai, Japan, International Immunology Meeting Abstracts (2010) 22 (Suppl 1 Pt 1): i138–i141. doi:10.1093/intimm/dxq108

  • Gadermaier E, Staikuniene J, Scheiblhofer S, Thalhamer J, Kundi M, Westritschnig K, Swoboda I, Flicker S, Valenta R (2011) Recombinant allergen-based monitoring of antibody responses during injection grass pollen immunotherapy and after 5 years of discontinuation. Allergy doi:10.1111/j.1398-9995.2011.02592.x

  • Ghetie V, Ward ES (2002) Transcytosis and catabolism of antibody. Immunol Res 25(2):97–113

    Article  CAS  PubMed  Google Scholar 

  • Ghetie V, Hubbard JG, Kim JK, Tsen MF, Lee Y, Ward ES (1996) Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice. Eur J Immunol 26(3):690–696

    Article  CAS  PubMed  Google Scholar 

  • Gieras A, Cejka P, Blatt K, Focke-Tejkl M, Linhart B, Flicker S, Stoecklinger A, Marth K, Drescher A, Thalhamer J, Valent P, Majdic O, Valenta R (2011) Mapping of conformational IgE epitopes with peptide-specific monoclonal antibodies reveals simultaneous binding of different IgE antibodies to a surface patch on the major birch pollen allergen, Bet v 1. J Immunol 186(9):5333–5344

    Article  CAS  PubMed  Google Scholar 

  • Glaser SM, Yelton DE, Huse WD (1992) Antibody engineering by codon-based mutagenesis in a filamentous phage vector system. J Immunol 149(12):3903–3913

    CAS  PubMed  Google Scholar 

  • Glovsky MM, Ghekiere L, Rejzek E (1991) Effect of maternal immunotherapy on immediate skin test reactivity, specific rye I IgG and IgE antibody, and total IgE of the children. Ann Allergy 67(1):21–24

    CAS  PubMed  Google Scholar 

  • Hansel TT, Kropshofer H, Singer T, Mitchell JA, George AJ (2010) The safety and side effects of monoclonal antibodies. Nat Rev Drug Discov 9(4):325–338

    Article  CAS  PubMed  Google Scholar 

  • Henderson LL, Larson JB, Gleich GJ (1975) Maximal rise in IgE antibody following ragweed pollination season. J Allergy Clin Immunol 55(1):10–15

    Article  CAS  PubMed  Google Scholar 

  • Holgate S, Smith N, Massanari M, Jimenez P (2009) Effects of omalizumab on markers of inflammation in patients with allergic asthma. Allergy 64(12):1728–1736

    Article  CAS  PubMed  Google Scholar 

  • Huse WD, Sastry L, Iverson SA, Kang AS, Alting-Mees M, Burton DR, Benkovic SJ, Lerner RA (1989) Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science 246(4935):1275–1281

    Article  CAS  PubMed  Google Scholar 

  • Jakobsen CG, Bodtger U, Kristensen P, Poulsen LK, Roggen EL (2004) Isolation of high-affinity human IgE and IgG antibodies recognising Bet v 1 and Humicola lanuginosa lipase from combinatorial phage libraries. Mol Immunol 41(10):941–953

    Article  CAS  PubMed  Google Scholar 

  • Jakobsen CG, Bodtger U, Poulsen LK, Roggen EL (2005) Vaccination for birch pollen allergy: comparison of the affinities of specific immunoglobulins E, G1 and G4 measured by surface plasmon resonance. Clin Exp Allergy 35(2):193–198

    Article  CAS  PubMed  Google Scholar 

  • Jefferis R (2007) Antibody therapeutics: isotype and glycoform selection. Expert Opin Biol Ther 7(9):1401–1413

    Article  CAS  PubMed  Google Scholar 

  • Jefferis R (2009a) Glycosylation as a strategy to improve antibody-based therapeutics. Nat Rev Drug Discov 8(3):226–234

    Article  CAS  Google Scholar 

  • Jefferis R (2009b) Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action. Trends Pharmacol Sci 30(7):356–362

    Article  CAS  Google Scholar 

  • Jenmalm MC, Bjorksten B (2000) Cord blood levels of immunoglobulin G subclass antibodies to food and inhalant allergens in relation to maternal atopy and the development of atopic disease during the first 8 years of life. Clin Exp Allergy 30(1):34–40

    Article  CAS  PubMed  Google Scholar 

  • Jutel M, Jaeger L, Suck R, Meyer H, Fiebig H, Cromwell O (2005) Allergen-specific immunotherapy with recombinant grass pollen allergens. J Allergy Clin Immunol 116(3):608–613

    Article  CAS  PubMed  Google Scholar 

  • Jylha S, Makinen-Kiljunen S, Haahtela T, Soderlund H, Takkinen K, Laukkanen ML (2009) Selection of recombinant IgE antibodies binding the beta-lactoglobulin allergen in a conformation-dependent manner. J Immunol Methods 350(1–2):63–70

    Article  PubMed  Google Scholar 

  • Kim SJ, Hong HJ (2007) Guided selection of human antibody light chains against TAG-72 using a phage display chain shuffling approach. J Microbiol 45(6):572–577

    CAS  PubMed  Google Scholar 

  • Klimek L, Bachert C, Doemer C, Meyer H, Narkus A (2005) Specific immunotherapy with recombinant brich pollen allergen rBet v 1-FV is clinically efficacious. Allergy Clin Immunol Int (suppl 1):15

    Google Scholar 

  • Laffer S, Steinberger P, Kraft D, Valenta R (2001) Promiscuous use of light chains by human IgE antibodies specific for three major grass pollen allergens. Int Arch Allergy Immunol 124(1–3):29–30

    Article  CAS  PubMed  Google Scholar 

  • Larche M, Akdis CA, Valenta R (2006) Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol 6(10):761–771

    Article  CAS  PubMed  Google Scholar 

  • Lebecque S, Dolecek C, Laffer S, Visco V, Denepoux S, Pin JJ, Guret C, Boltz-Nitulescu G, Weyer A, Valenta R (1997) Immunologic characterization of monoclonal antibodies that modulate human IgE binding to the major birch pollen allergen Bet v 1. J Allergy Clin Immunol 99(3):374–384

    Article  CAS  PubMed  Google Scholar 

  • Li M, Gustchina A, Alexandratos J, Wlodawer A, Wunschmann S, Kepley CL, Chapman MD, Pomes A (2008) Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody. J Biol Chem 283(33):22806–22814

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Loveless M (1940) Immunological studies of pollinosis. I. The presence of two antibodies related to the same pollen antigen in the serum of treated hay fever patients. J Immunol 38:25–50

    CAS  Google Scholar 

  • Malbec O, Daeron M (2007) The mast cell IgG receptors and their roles in tissue inflammation. Immunol Rev 217:206–221

    Article  CAS  PubMed  Google Scholar 

  • McCafferty J, Griffiths AD, Winter G, Chiswell DJ (1990) Phage antibodies: filamentous phage displaying antibody variable domains. Nature 348(6301):552–554

    Article  CAS  PubMed  Google Scholar 

  • Mertsching E, Bafetti L, Hess H, Perper S, Giza K, Allen LC, Negrou E, Hathaway K, Hopp J, Chung J, Perret D, Shields M, Saxon A, Kehry MR (2008) A mouse Fcgamma-Fcepsilon protein that inhibits mast cells through activation of FcgammaRIIB, SH2 domain-containing inositol phosphatase 1, and SH2 domain-containing protein tyrosine phosphatases. J Allergy Clin Immunol 121(2):441–447

    Article  CAS  PubMed  Google Scholar 

  • Mirza O, Henriksen A, Ipsen H, Larsen JN, Wissenbach M, Spangfort MD, Gajhede M (2000) Dominant epitopes and allergic cross-reactivity: complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen Bet v 1. J Immunol 165(1):331–338

    CAS  PubMed  Google Scholar 

  • Moerch U, Haahr Hansen M, Vest Hansen NJ, Rasmussen LK, Oleksiewicz MB, Frandsen TP, Haurum JS, Bregenholt S (2006) Allergen-specific polyclonal antibodies reduce allergic disease in a mouse model of allergic asthma. Int Arch Allergy Immunol 140(3):261–269

    Article  CAS  PubMed  Google Scholar 

  • Mothes N, Heinzkill M, Drachenberg KJ, Sperr WR, Krauth MT, Majlesi Y, Semper H, Valent P, Niederberger V, Kraft D, Valenta R (2003) Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies. Clin Exp Allergy 33(9):1198–1208

    Article  CAS  PubMed  Google Scholar 

  • Muller UR, Morris T, Bischof M, Friedli H, Skarvil F (1986) Combined active and passive immunotherapy in honeybee-sting allergy. J Allergy Clin Immunol 78(1 Pt 1):115–122

    Article  CAS  PubMed  Google Scholar 

  • Niederberger V, Horak F, Vrtala S, Spitzauer S, Krauth MT, Valent P, Reisinger J, Pelzmann M, Hayek B, Kronqvist M, Gafvelin G, Gronlund H, Purohit A, Suck R, Fiebig H, Cromwell O, Pauli G, van Hage-Hamsten M, Valenta R (2004) Vaccination with genetically engineered allergens prevents progression of allergic disease. Proc Natl Acad Sci USA 101(suppl 2):14677–14682

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Niederberger V, Reisinger J, Valent P, Krauth MT, Pauli G, van Hage M, Cromwell O, Horak F, Valenta R (2007a) Vaccination with genetically modified birch pollen allergens: immune and clinical effects on oral allergy syndrome. J Allergy Clin Immunol 119(4):1013–1016

    Article  CAS  Google Scholar 

  • Niederberger V, Ring J, Rakoski J, Jager S, Spitzauer S, Valent P, Horak F, Kundi M, Valenta R (2007b) Antigens drive memory IgE responses in human allergy via the nasal mucosa. Int Arch Allergy Immunol 142(2):133–144

    Article  CAS  Google Scholar 

  • Niemi M, Jylha S, Laukkanen ML, Soderlund H, Makinen-Kiljunen S, Kallio JM, Hakulinen N, Haahtela T, Takkinen K, Rouvinen J (2007) Molecular interactions between a recombinant IgE antibody and the beta-lactoglobulin allergen. Structure 15(11):1413–1421

    Article  CAS  PubMed  Google Scholar 

  • Padavattan S, Schirmer T, Schmidt M, Akdis C, Valenta R, Mittermann I, Soldatova L, Slater J, Mueller U, Markovic-Housley Z (2007) Identification of a B-cell epitope of hyaluronidase, a major bee venom allergen, from its crystal structure in complex with a specific Fab. J Mol Biol 368(3):742–752

    Article  CAS  PubMed  Google Scholar 

  • Padavattan S, Flicker S, Schirmer T, Madritsch C, Randow S, Reese G, Vieths S, Lupinek C, Ebner C, Valenta R, Markovic-Housley Z (2009) High-affinity IgE recognition of a conformational epitope of the major respiratory allergen Phl p 2 as revealed by X-ray crystallography. J Immunol 182(4):2141–2151

    Article  CAS  PubMed  Google Scholar 

  • Pauli G, Larsen TH, Rak S, Horak F, Pastorello E, Valenta R, Purohit A, Arvidsson M, Kavina A, Schroeder JW, Mothes N, Spitzauer S, Montagut A, Galvain S, Melac M, Andre C, Poulsen LK, Malling HJ (2008) Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitis. J Allergy Clin Immunol 122(5):951–960

    Article  CAS  PubMed  Google Scholar 

  • Persson H, Lantto J, Ohlin M (2006) A focused antibody library for improved hapten recognition. J Mol Biol 357(2):607–620

    Article  CAS  PubMed  Google Scholar 

  • Persson H, Wallmark H, Ljungars A, Hallborn J, Ohlin M (2008) In vitro evolution of an antibody fragment population to find high-affinity hapten binders. Protein Eng Des Sel 21(8):485–493

    Article  CAS  PubMed  Google Scholar 

  • Petersen BN, Janniche H, Munch EP, Wihl JA, Bowadt H, Ipsen H, Lowenstein H (1988) Immunotherapy with partially purified and standardized tree pollen extracts. I. Clinical results from a three-year double-blind study of patients treated with pollen extracts either of birch or combinations of alder, birch and hazel. Allergy 43(5):353–362

    Article  CAS  PubMed  Google Scholar 

  • Petkova SB, Akilesh S, Sproule TJ, Christianson GJ, Al Khabbaz H, Brown AC, Presta LG, Meng YG, Roopenian DC (2006) Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease. Int Immunol 18(12):1759–1769

    Article  CAS  PubMed  Google Scholar 

  • Polte T, Hansen G (2008) Maternal tolerance achieved during pregnancy is transferred to the offspring via breast milk and persistently protects the offspring from allergic asthma. Clin Exp Allergy 38(12):1950–1958

    Article  CAS  PubMed  Google Scholar 

  • Polte T, Hennig C, Hansen G (2008) Allergy prevention starts before conception: maternofetal transfer of tolerance protects against the development of asthma. J Allergy Clin Immunol 122(5):1022–1030 e5

    Article  CAS  PubMed  Google Scholar 

  • Prausnitz C, Küstner H (1921) Studien über die Ãœberempfindlichkeit. Zbl Bakt 86:160–169

    Google Scholar 

  • Pree I, Reisinger J, Focke M, Vrtala S, Pauli G, van Hage M, Cromwell O, Gadermaier E, Egger C, Reider N, Horak F, Valenta R, Niederberger V (2007) Analysis of epitope-specific immune responses induced by vaccination with structurally folded and unfolded recombinant Bet v 1 allergen derivatives in man. J Immunol 179(8):5309–5316

    CAS  PubMed  Google Scholar 

  • Pree I, Shamji MH, Kimber I, Valenta R, Durham SR, Niederberger V (2010) Inhibition of CD23-dependent facilitated allergen binding to B cells following vaccination with genetically modified hypoallergenic Bet v 1 molecules. Clin Exp Allergy 40(9):1346–1352

    Article  CAS  PubMed  Google Scholar 

  • Presta LG (2006) Engineering of therapeutic antibodies to minimize immunogenicity and optimize function. Adv Drug Deliv Rev 58(5–6):640–656

    Article  CAS  PubMed  Google Scholar 

  • Presta LG (2008) Molecular engineering and design of therapeutic antibodies. Curr Opin Immunol 20(4):460–470

    Article  CAS  PubMed  Google Scholar 

  • Purohit A, Niederberger V, Kronqvist M, Horak F, Gronneberg R, Suck R, Weber B, Fiebig H, van Hage M, Pauli G, Valenta R, Cromwell O (2008) Clinical effects of immunotherapy with genetically modified recombinant birch pollen Bet v 1 derivatives. Clin Exp Allergy 38(9):1514–1525

    Article  CAS  PubMed  Google Scholar 

  • Radauer C, Bublin M, Wagner S, Mari A, Breiteneder H (2008) Allergens are distributed into few protein families and possess a restricted number of biochemical functions. J Allergy Clin Immunol 121(4):847–852 e7

    Article  CAS  PubMed  Google Scholar 

  • Rojas G, Talavera A, Munoz Y, Rengifo E, Krengel U, Angstrom J, Gavilondo J, Moreno E (2004) Light-chain shuffling results in successful phage display selection of functional prokaryotic-expressed antibody fragments to N-glycolyl GM3 ganglioside. J Immunol Methods 293(1–2):71–83

    Article  CAS  PubMed  Google Scholar 

  • Roopenian DC, Akilesh S (2007) FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol 7(9):715–725

    Article  CAS  PubMed  Google Scholar 

  • Sawyer LA (2000) Antibodies for the prevention and treatment of viral diseases. Antiviral Res 47(2):57–77

    Article  CAS  PubMed  Google Scholar 

  • Sehra S, Pynaert G, Tournoy K, Haegeman A, Matthys P, Tagawa Y, Pauwels R, Grooten J (2003) Airway IgG counteracts specific and bystander allergen-triggered pulmonary inflammation by a mechanism dependent on Fc gamma R and IFN-gamma. J Immunol 171(4):2080–2089

    CAS  PubMed  Google Scholar 

  • Steinberger P, Kraft D, Valenta R (1996) Construction of a combinatorial IgE library from an allergic patient. Isolation and characterization of human IgE Fabs with specificity for the major timothy grass pollen allergen, Phl p 5. J Biol Chem 271(18):10967–10972

    Article  CAS  PubMed  Google Scholar 

  • Strait RT, Morris SC, Finkelman FD (2006) IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking. J Clin Invest 116(3):833–841

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Tam SW, Demissie S, Thomas D, Daeron M (2004) A bispecific antibody against human IgE and human FcgammaRII that inhibits antigen-induced histamine release by human mast cells and basophils. Allergy 59(7):772–780

    Article  CAS  PubMed  Google Scholar 

  • Uermosi C, Beerli RR, Bauer M, Manolova V, Dietmeier K, Buser RB, Kundig TM, Saudan P, Bachmann MF (2010) Mechanisms of allergen-specific desensitization. J Allergy Clin Immunol 126(2):375–383

    Article  PubMed  Google Scholar 

  • Uthoff H, Spenner A, Reckelkamm W, Ahrens B, Wolk G, Hackler R, Hardung F, Schaefer J, Scheffold A, Renz H, Herz U (2003) Critical role of preconceptional immunization for protective and nonpathological specific immunity in murine neonates. J Immunol 171(7):3485–3492

    CAS  PubMed  Google Scholar 

  • Valenta R, Kraft D (1995) Recombinant allergens for diagnosis and therapy of allergic diseases. Curr Opin Immunol 7(6):751–756

    Article  CAS  PubMed  Google Scholar 

  • Valenta R, Kraft D (2002) From allergen structure to new forms of allergen-specific immunotherapy. Curr Opin Immunol 14(6):718–727

    Article  CAS  PubMed  Google Scholar 

  • Valenta R, Steinberger P, Duchene M, Kraft D (1996) Immunological and structural similarities among allergens: prerequisite for a specific and component-based therapy of allergy. Immunol Cell Biol 74(2):187–194

    Article  CAS  PubMed  Google Scholar 

  • Valenta R, Ferreira F, Focke-Tejkl M, Linhart B, Niederberger V, Swoboda I, Vrtala S (2010) From allergen genes to allergy vaccines. Ann Rev Immunol 28:211–214

    Article  CAS  Google Scholar 

  • van Neerven RJ, Wikborg T, Lund G, Jacobsen B, Brinch-Nielsen A, Arnved J, Ipsen H (1999) Blocking antibodies induced by specific allergy vaccination prevent the activation of CD4 + T cells by inhibiting serum-IgE-facilitated allergen presentation. J Immunol 163(5):2944–2952

    PubMed  Google Scholar 

  • van Neerven RJ, Arvidsson M, Ipsen H, Sparholt SH, Rak S, Wurtzen PA (2004) A double-blind, placebo-controlled birch allergy vaccination study: inhibition of CD23-mediated serum-immunoglobulin E-facilitated allergen presentation. Clin Exp Allergy 34(3):420–428

    Article  PubMed  Google Scholar 

  • Victor JR, Muniz BP, Fusaro AE, de Brito CA, Taniguchi EF, Duarte AJ, Sato MN (2010) Maternal immunization with ovalbumin prevents neonatal allergy development and up-regulates inhibitory receptor Fc gamma RIIB expression on B cells. BMC Immunol 11:11

    Article  PubMed Central  PubMed  Google Scholar 

  • Visco V, Dolecek C, Denepoux S, Le Mao J, Guret C, Rousset F, Guinnepain MT, Kraft D, Valenta R, Weyer A, Banchereau J, Labecque S (1996) Human IgG monoclonal antibodies that modulate the binding of specific IgE to birch pollen Bet v 1. J Immunol 157(2):956–962

    CAS  PubMed  Google Scholar 

  • von Behring E, Kitasato S (1991) The mechanism of diphtheria immunity and tetanus immunity in animals. 1890. Mol Immunol 28(12):1317 1319–1320

    Article  Google Scholar 

  • Wachholz PA, Durham SR (2004) Mechanisms of immunotherapy: IgG revisited. Curr Opin Allergy Clin Immunol 4(4):313–318

    Article  CAS  PubMed  Google Scholar 

  • Wachholz PA, Soni NK, Till SJ, Durham SR (2003) Inhibition of allergen-IgE binding to B cells by IgG antibodies after grass pollen immunotherapy. J Allergy Clin Immunol 112(5):915–922

    Article  CAS  PubMed  Google Scholar 

  • Winter G, Griffiths AD, Hawkins RE, Hoogenboom HR (1994) Making antibodies by phage display technology. Annu Rev Immunol 12:433–455

    Article  CAS  PubMed  Google Scholar 

  • Wu H, Beuerlein G, Nie Y, Smith H, Lee BA, Hensler M, Huse WD, Watkins JD (1998) Stepwise in vitro affinity maturation of Vitaxin, an alphav beta3-specific humanized mAb. Proc Natl Acad Sci USA 95(11):6037–6042

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Yeung YA, Leabman MK, Marvin JS, Qiu J, Adams CW, Lien S, Starovasnik MA, Lowman HB (2009) Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pharmacokinetics in primates. J Immunol 182(12):7663–7671

    Article  CAS  PubMed  Google Scholar 

  • Zhang K, Kepley CL, Terada T, Zhu D, Perez H, Saxon A (2004) Inhibition of allergen-specific IgE reactivity by a human Ig Fcgamma-Fcepsilon bifunctional fusion protein. J Allergy Clin Immunol 114(2):321–327

    Article  CAS  PubMed  Google Scholar 

  • Zhu D, Kepley CL, Zhang M, Zhang K, Saxon A (2002) A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation. Nat Med 8(5):518–521

    Article  CAS  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Vienna General Hospital, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria

    Sabine Flicker, Elisabeth Gadermaier, Christoph Madritsch & Rudolf Valenta

Authors
  1. Sabine Flicker
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Elisabeth Gadermaier
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Christoph Madritsch
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Rudolf Valenta
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sabine Flicker .

Editor information

Editors and Affiliations

  1. Christian Doppler Laboratory for Allergy, Medical University of Vienna, Vienna, Austria

    Rudolf Valenta

  2. Dynavax Technologies, Berkeley, California, USA

    Robert L. Coffman

Rights and permissions

Reprints and permissions

Copyright information

© 2011 2011

About this chapter

Cite this chapter

Flicker, S., Gadermaier, E., Madritsch, C., Valenta, R. (2011). Passive Immunization with Allergen-Specific Antibodies. In: Valenta, R., Coffman, R. (eds) Vaccines against Allergies. Current Topics in Microbiology and Immunology, vol 352. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2011_143

Download citation

Publish with us

Policies and ethics

Search

Navigation