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Roles of Cellular Transcription Factors in VZV Replication

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Varicella-zoster Virus

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 342))

Abstract

Varicella zoster virus (VZV) is the causative agent of chickenpox and shingles. During productive infection the complete VZV proteome consisting of some 68 unique gene products is expressed through interaction of a small number of viral transcriptional activators with the general transcription apparatus of the host cell. Recent work has shown that the major viral transactivator, commonly designated the IE62 protein, interacts with the human Mediator of transcription. This interaction requires direct contact between the MED25 subunit of Mediator and the acidic N-terminal transactivation domain of IE62. A second cellular factor, host cell factor-1, has been shown to be the common element in two mechanisms of activation of the promoter driving expression of the gene encoding IE62. Finally, the ubiquitous cellular transcription factors Sp1, Sp3, and YY1 have been shown to interact with sequences near the VZV origin of DNA replication and in the case of Sp1/Sp3 to influence replication efficiency.

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Acknowledgment

The work from the author’s laboratory described in this chapter was supported by Grants AI18449 and AI36884 from the National Institutes of Health.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo SUNY, 138 Farber Hall, Buffalo, NY, 14214, USA

    William T. Ruyechan

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  1. William T. Ruyechan
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Correspondence to William T. Ruyechan .

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Editors and Affiliations

  1. Department of Infectious Diseases and Im, Head, VZV Research Laboratory, University of Sydney, Room 601 Blackburn Building D06, Sydney, 2006, New South Wales, Australia

    Allison Abendroth

  2. School of Medicine, Dept. Microbiology & Immunology, Stanford University, Pasteur Drive 300, Stanford, 94305-5124, California, USA

    Ann M. Arvin

  3. 2215 Weiskotten Hall, Upstate Medical University, East Adams Street 750, Syracuse, 13210, New York, USA

    Jennifer F. Moffat

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Ruyechan, W.T. (2010). Roles of Cellular Transcription Factors in VZV Replication. In: Abendroth, A., Arvin, A., Moffat, J. (eds) Varicella-zoster Virus. Current Topics in Microbiology and Immunology, vol 342. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2010_42

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