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Chemokine Decoy Receptors: Structure–Function and Biological Properties

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The Chemokine System in Experimental and Clinical Hematology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 341))

Abstract

Chemokines induce cell migration through the activation of a distinct family of structurally related heterotrimeric G protein-coupled receptors (GPCR). Over the last few years, several receptors in this family that recognize chemokines but do not induce cell migration have been identified. These “atypical” chemokine receptors are unable to activate transduction events that lead directly to cell migration, but appear nonetheless to play a nonredundant role in the control of leukocyte recruitment at inflammatory sites and in tumors by shaping the chemoattractant gradient, either by removing, transporting, or concentrating their cognate ligands.

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Abbreviations

GPCR:

G-protein-coupled receptors

CCL:

CC chemokine ligand

CXCL:

CXC chemokine ligand

CCR:

CC chemokine receptor

CXCR:

CXC chemokine receptor

DARC:

Duffy antigen receptor for chemokines

HCV:

Hepatitis C virus

LPS:

Lipopolysaccharide

MMP-9:

Metallo protease 9

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Acknowledgments

This study was supported by the European Union FP6 (INNOCHEM: contract LSHB-CT-2005-518167), the CARIPLO Foundation (NOBEL project and contract 2008/2279), and the Italian Association for Cancer Research (AIRC) and progetti di ricerca di interesse nazionale (PRIN) of Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR), Italy. EMB and BS are supported by a fellowship from the Italian Foundation for Cancer Research (FIRC).

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Authors and Affiliations

  1. Department of Translational Medicine, University of Milan, 20089, Rozzano, Milan, Italy

    Raffaella Bonecchi, Benedetta Savino, Elena M. Borroni, Alberto Mantovani & Massimo Locati

  2. IRCCS Istituto Clinico Humanitas, Via Manzoni 56, Rozzano, 20089, Milan, Italy

    Raffaella Bonecchi, Benedetta Savino, Elena M. Borroni, Alberto Mantovani & Massimo Locati

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  1. Raffaella Bonecchi
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  2. Benedetta Savino
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  3. Elena M. Borroni
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  4. Alberto Mantovani
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  5. Massimo Locati
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Corresponding author

Correspondence to Alberto Mantovani .

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  1. Dept. Medicine, Div. Infectious Diseases, Haukeland University Hospital, Bergen, 5021, Norway

    Oystein Bruserud

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Bonecchi, R., Savino, B., Borroni, E.M., Mantovani, A., Locati, M. (2010). Chemokine Decoy Receptors: Structure–Function and Biological Properties. In: Bruserud, O. (eds) The Chemokine System in Experimental and Clinical Hematology. Current Topics in Microbiology and Immunology, vol 341. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2010_19

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