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A Systems Neuroscience Approach to the Pathophysiology of Pediatric Mood and Anxiety Disorders

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The Neurobiology of Childhood

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 16))

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Abstract

Emotional dysregulation is a core feature of pediatric mood and anxiety disorders. Emerging evidence suggests that these disorders are mediated by abnormalities in the functions and structures of the developing brain. This chapter reviews recent behavioral and functional magnetic resonance imaging (fMRI) research on pediatric mood and anxiety disorders, focusing on the neural mechanisms underlying these disorders. Throughout the chapter, we highlight the relationship between neural and behavioral findings, and potential novel treatments. The chapter concludes with directions for future research.

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Authors and Affiliations

  1. Department of Health and Human Services, Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, 15K North Drive, MSC 2670, Bethesda, MD, 20892, USA

    Wan-Ling Tseng & Ellen Leibenluft

  2. Department of Health and Human Services, Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD , 20892, USA

    Melissa A. Brotman

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  1. Wan-Ling Tseng
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  2. Ellen Leibenluft
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  3. Melissa A. Brotman
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Correspondence to Wan-Ling Tseng .

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Editors and Affiliations

  1. McLean Hospital Harvard Medical School, Belmont, Massachusetts, USA

    Susan L. Andersen

  2. NIMH, Bethesda, USA

    Daniel S. Pine

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Tseng, WL., Leibenluft, E., Brotman, M.A. (2013). A Systems Neuroscience Approach to the Pathophysiology of Pediatric Mood and Anxiety Disorders. In: Andersen, S., Pine, D. (eds) The Neurobiology of Childhood. Current Topics in Behavioral Neurosciences, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2013_252

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