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Nano-Enabled Delivery of Intracellular Therapeutics

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Personalized Medicine with a Nanochemistry Twist

Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 20))

Abstract

Many diseases that plague the modern medical world have their origins at the cellular or molecular level and, as such, require greater specificity to be effectively combated and cured. A number of recent advances in understanding the biology and biochemistry have enabled researchers to develop the specialized tools and techniques needed to detect and provide therapy for these debilitating conditions. Many of these treatments take advantage of the way that cells behave and interact with their environment or various properties of the cell’s structure and form. Researchers are able to surpass a number of cellular hurdles, such as the cell membrane, endosomal escape, and intracellular targeting to begin the arduous task of understanding, diagnosing, and treating diseases like cancer.

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Abbreviations

ATP:

Adenosine triphosphate

CIE:

Clathrin-independent endocytosis

CLIC:

Clathrin- and dynamin-independent carriers

CME:

Clathrin-mediated endocytosis

CPP:

Cell penetrating peptides

CPT:

Camptothecin

DNP:

Dinitrophenol

ECM:

Extracellular matrix

EGFR:

Epidermal growth factor receptors

ER:

Endoplasmic reticulum

ETC:

Electron transport chain

FR:

Fc receptor

GUV:

Giant unilamellar vesicle

HP:

Hematoporphyrin

NLS:

Nuclear localization sequence

NP:

Nanoparticle

NPC:

Nuclear pore complex

PC:

Phophatidylcholine

PCI:

Photo-chemical internalization

PE:

Phosphatidylethanolamine

PEG:

Poly-ethylene glycol

PS:

Phosphatidylserine

PSMA:

Prostate-specific membrane antigens

RES:

Reticulo-endothelial system

ROS:

Reactive oxygen species

TCHD:

Trans-cyclohexane-1,2-diol

TIM:

Transporter inner membrane

TOM:

Transporter outer membrane

TPP:

Triphenylphosphonium

TR:

Transferrin receptors

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Author information

Authors and Affiliations

  1. Department of Bioengineering, College of Engineering, University of Illinois at Urbana Champaign, Urbana, IL, USA

    Fatemeh Ostadhossein, Enrique Alejandro Daza, Daniel Frankowski, Drew Goatz, Molly Imgruet, Joseph Kus, Mallika Modak, Nick Olsen, Aaron Schwartz-Duval, Alyssa Zimmer & Nicholas Kolmodin

  2. Department of Chemistry, College of Engineering, University of Illinois at Urbana Champaign, Urbana, IL, USA

    Ryan Lake

  3. Department of Bioengineering, University of Illinois at Urbana Champaign, Urbana, IL, USA

    Dipanjan Pan

  4. Beckman Institute for Science and Technology, Urbana, IL, USA

    Dipanjan Pan

  5. Department of Materials Science and Engineering, University of Illinois at Urbana Champaign, Urbana, IL, USA

    Dipanjan Pan

  6. Carle Foundation Hospital, Urbana, IL, USA

    Dipanjan Pan

Authors
  1. Fatemeh Ostadhossein
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  2. Enrique Alejandro Daza
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  3. Daniel Frankowski
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  4. Drew Goatz
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  5. Molly Imgruet
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  6. Joseph Kus
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  7. Ryan Lake
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  8. Mallika Modak
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  9. Nick Olsen
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  10. Aaron Schwartz-Duval
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  11. Alyssa Zimmer
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  12. Nicholas Kolmodin
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  13. Dipanjan Pan
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Corresponding author

Correspondence to Dipanjan Pan .

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Editors and Affiliations

  1. Department of Bioengineering, University of Illinois at Urbana Champain, Urbana, Illinois, USA

    Dipanjan Pan

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Ostadhossein, F. et al. (2015). Nano-Enabled Delivery of Intracellular Therapeutics. In: Pan, D. (eds) Personalized Medicine with a Nanochemistry Twist. Topics in Medicinal Chemistry, vol 20. Springer, Cham. https://doi.org/10.1007/7355_2015_97

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