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Blood–Brain Barrier and Stroke

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The Blood Brain Barrier (BBB)

Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 10))

Abstract

Stroke disintegrates communications within a highly dynamic and regulated ensemble of cells that constitutes the blood–brain barrier (BBB), endothelial cells, astrocytic end feet that surround blood vessels, the basement membrane (BM)/extracellular matrix (ECM), and pericytes, inducing and propagating injury. We discuss the effects of experimental stroke on individual cell constituents of the BBB and how these changes affect structural and functional integrity of the BBB in relation to acute injury and repair. The age at the time of stroke, from the newborn period to adulthood and older, can markedly affect the particulars of deregulation, processes that we also discuss in this chapter.

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Acknowledgements

The authors have been supported by RO1 NS55915 (Z.S.V), RO1 NS44025 (Z.S.V), R21 NS80015 (Z.S.V), NS35902 (Z.S.V), AHA GIA 0855235F (Z.S.V), Ramon Areces Foundation, Madrid, Spain (D.F.L), and AHA postdoctoral fellowship (D.F.L.).

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  1. Department of Neurology, University of California San Francisco, San Francisco, CA, USA

    David Fernández-López & Zinaida S. Vexler

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  1. David Fernández-López
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  2. Zinaida S. Vexler
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Correspondence to Zinaida S. Vexler .

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  1. Institut für Pharmazie und Molekulare Biotechnologie, Universität Heidelberg, Heidelberg, Baden-Württemberg, Germany

    Gert Fricker

  2. Dept. for Pharmaceutical Technology and Pharmacology, Institute für Pharmacy and Molecular Biotechnology, Heidelberg, Germany

    Melanie Ott

  3. Dept. for Pharmaceutical Technology and Pharmacology, Institute für Pharmacy and Molecular Biotechnology, Heidelberg, Germany

    Anne Mahringer

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Fernández-López, D., Vexler, Z.S. (2013). Blood–Brain Barrier and Stroke. In: Fricker, G., Ott, M., Mahringer, A. (eds) The Blood Brain Barrier (BBB). Topics in Medicinal Chemistry, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7355_2013_23

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