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Organization and Assembly of the Mycoplasma pneumoniae Attachment Organelle

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Complex Intracellular Structures in Prokaryotes

Part of the book series: Microbiology Monographs ((MICROMONO,volume 2))

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Abstract

Mycoplasma pneumoniae synthesizes a complex polar structure,the attachment organelle (AO), which is required for productive adherence to host cells. Because in natureM. pneumoniae cannot survive outside the host, this structure is essentialto the M. pneumoniae cell. While it is understood that the AO is thesite at which adhesin proteins are concentrated, how that localization is mediated is unknown. However,the presence at the AO of a set of novel, detergent-insoluble proteins and structures which are indirectlyrequired for normal function of this structure has provided insight into its assembly and architecture.Biochemical, genetic, and immunocytochemical studies of these cytadherence-accessory proteins and theirinterrelationships have revealed remarkable complexity in this supposedly minimal bacterial cell.

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Acknowledgments

I thank J. Hatchel, M. Duley, S. Ross, and D. Krause for providing electron micrographs. This work was supported by Miami University startup funds.

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Authors and Affiliations

  1. Department of Microbiology, Miami University, 45056, Oxford, OH, USA

    Mitchell F. Balish

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  1. Mitchell F. Balish
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Correspondence to Mitchell F. Balish .

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Jessup M. Shively

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© 2006 Springer-Verlag Berlin Heidelberg

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Balish, M.F. (2006). Organization and Assembly of the Mycoplasma pneumoniae Attachment Organelle. In: Shively, J.M. (eds) Complex Intracellular Structures in Prokaryotes. Microbiology Monographs, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7171_031

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