Abstract
The [3+2] cycloaddition reaction between an alkyne and nitrone in the presence of copper catalyst leading to the formation of β-lactam is known as the Kinugasa reaction. Over the years, the Kinugasa reaction has been established as a robust and versatile route for the synthesis of β-lactam derivatives in both cis and trans configuration. This review has focused on various approaches highlighting recent stereoselective syntheses along with plausible mechanisms and other salient features.
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Mandal, B., Basu, B. (2012). Synthesis of β-Lactams Through Alkyne–Nitrone Cycloadditions. In: Banik, B. (eds) β-Lactams: Unique Structures of Distinction for Novel Molecules. Topics in Heterocyclic Chemistry, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_2012_85
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DOI: https://doi.org/10.1007/7081_2012_85
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