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Dosimetry and Toxicology of Nanosized Particles and Fibres

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Indoor and Outdoor Nanoparticles

Part of the book series: The Handbook of Environmental Chemistry ((HEC,volume 48))

Abstract

Once inhaled, nanomaterials (particles and fibres) have a high probability of deposition in the lungs mainly by diffusion and to be transported throughout the body. The chemical composition and surface reactivity and dissolution rates are the driving forces for toxicity often starting with oxidative stress which can lead to inflammation, systemic effects or even lung cancer.

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Author information

Authors and Affiliations

  1. National Institute of Public Health and the Environment, Bilthoven, The Netherlands

    Flemming R. Cassee

  2. Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg/Munich, Germany

    Wolfgang Kreyling

  3. Institute of Occupational Medicine, Singapore, Singapore

    Rob Aitken

  4. Institute of Occupational Medicine, Edinburgh, UK

    Craig Poland

Authors
  1. Flemming R. Cassee
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  2. Wolfgang Kreyling
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  3. Rob Aitken
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  4. Craig Poland
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Corresponding author

Correspondence to Flemming R. Cassee .

Editor information

Editors and Affiliations

  1. Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Barcelona, Spain

    Mar Viana

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Cassee, F.R., Kreyling, W., Aitken, R., Poland, C. (2015). Dosimetry and Toxicology of Nanosized Particles and Fibres. In: Viana, M. (eds) Indoor and Outdoor Nanoparticles. The Handbook of Environmental Chemistry, vol 48. Springer, Cham. https://doi.org/10.1007/698_2015_415

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