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Disrupting Effects of Single and Combined Emerging Pollutants on Thyroid Gland Function

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Emerging Organic Contaminants and Human Health

Part of the book series: The Handbook of Environmental Chemistry ((HEC,volume 20))

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Abstract

Inadequate thyroid hormone (TH) production in mothers during the first months of pregnancy can produce irreversible neurological effects in the offspring. Even though the main cause of insufficient synthesis of TH is the lack of iodine in the diet, TH insufficiency can also be caused by the presence of some naturally occurring and synthetic chemicals disrupting the thyroid gland function. The identification of emerging pollutants that may interfere with mammalian thyroid gland function is still in progress. The goal of this chapter is to review the potential of the zebrafish eleutheroembryos, a vertebrate model used in toxicology and by pharmaceutical companies in drug discovery, as a predictive model for screening emerging pollutants and drugs having a direct effect on the mammalian thyroid gland function.

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Abbreviations

API:

Average pixel intensity

BP2:

Benzophenone 2

CA:

Concentration-addition

CNS:

Central nervous system

DIT:

Diiodotyrosine

EGL:

External granule layer

ETU:

Ethylene thiourea

IA:

Independent-action

ID:

Iodine deficiency

IT4C:

Intrafollicular T4 content

MIT:

Monoiodotyrosine

MMI:

Methimazole

MoA:

Mode of action

NIS:

Sodium-iodide symporter

NOEC:

No observed effect concentration

PTUracil:

6-Propyl-2-thiouracil

T3:

3,5,3′-Triiodothyronine

T4:

Thyroxine

TG:

Thyroglobulin

TGFD:

Thyroid gland function disruptor

TH:

Thyroid hormones

TIQDT:

Thyroxine immunofluorescence quantitative disruption test

TPO:

Thyroperoxidase

TSH:

Thyroid-stimulating hormone (thyrotropin)

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Acknowledgments

This work has been supported by the Spanish Ministry of Science and Innovation (CTM2011-30471-C02-01 and PA1002979) and the Generalitat de Catalunya (2010 BE1 00623) to D.R. and C.B. B.T. was supported by a fellowship of the Spanish Government (AP2006-01324). This work was supported by a Conseil Régional d’Aquitaine grant (200881301031/TOD project) to P.J.B.

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Authors and Affiliations

  1. Institute of Environmental Assessment and Water Research (IDÆA-CSIC), Jordi Girona 18, 08034, Barcelona, Spain

    Demetrio Raldúa, Carlos Barata & Benedicte Thienpont

  2. University of Bordeaux, Maladies Rares: Génétique et Métabolisme (MRGM) EA4576, 33400, Talence, France

    Patrick J. Babin

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  1. Demetrio Raldúa
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  2. Patrick J. Babin
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  4. Benedicte Thienpont
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Correspondence to Demetrio Raldúa .

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  1. Jordi Girona 18 -26, Barcelona, 08034, Spain

    Damià Barceló

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Raldúa, D., Babin, P.J., Barata, C., Thienpont, B. (2011). Disrupting Effects of Single and Combined Emerging Pollutants on Thyroid Gland Function. In: Barceló, D. (eds) Emerging Organic Contaminants and Human Health. The Handbook of Environmental Chemistry(), vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/698_2011_123

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