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Updates on Therapeutic Strategies Against Candida (and Aspergillus) Biofilm Related Infections

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Fungal Biofilms and related infections

Part of the book series: Advances in Experimental Medicine and Biology ((AMIDPH,volume 931))

Abstract

Fungal biofilm related infections are commonly associated with medical devices with biofilms contributing to the virulence of the involved fungal species. If infection does occur, removal of medical device is often warranted. However, this is not always possible. Moreover, biofilm associated infections are often resistant to antifungals and host immunity. Therefore, a need for new agents and strategies to combat these devastating infections is needed. Although no randomized clinical trials have been conducted or are likely to be conducted in the future, the Infectious Disease Society of America (IDSA) and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) utilized available published data and clinical experience of the infectious disease community to propose strategies to treat biofilm associated devise infections. In this chapter we describe the emerging therapies for biofilm related infections.

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Authors and Affiliations

  1. Department of Dermatology, Center for Medical Mycology, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, 44106, USA

    Fuad Kamel Muakkassa & Mahmoud Ghannoum

Authors
  1. Fuad Kamel Muakkassa
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  2. Mahmoud Ghannoum
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Correspondence to Mahmoud Ghannoum .

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Editors and Affiliations

  1. Laboratory Ecology & Biology of Interactions UMR CNRS 7267, University of Poitiers, Poitiers, France

    Christine Imbert

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Muakkassa, F.K., Ghannoum, M. (2016). Updates on Therapeutic Strategies Against Candida (and Aspergillus) Biofilm Related Infections. In: Imbert, C. (eds) Fungal Biofilms and related infections. Advances in Experimental Medicine and Biology(), vol 931. Springer, Cham. https://doi.org/10.1007/5584_2016_11

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