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The Hsp60 chaperonins from prokaryotes and eukaryotes

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Chaperones

Part of the book series: Topics in Current Genetics ((TCG,volume 16))

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Abstract

The Hsp60 molecular chaperones (the chaperonins) are essential proteins throughout biology. They can be separated into two evolutionary classes: the Group I chaperonins from eubacteria and their endosymbiotic counterparts in eukaryotic cells, and the Group II chaperonins from archaea and the eukaryotic cytosol. While the two classes have some similarity to each other in structural and functional characteristics, they also have a number of important distinctions implying that they may have some significant differences in their modes of action. In this review we first examine our current understanding of the Group I class, typified by GroE from Escherichia coli, before looking at the recent developments in the much less well-studied Group II chaperonins, including the archeal thermosome and eukaryotic CCT.

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  1. Department of Biochemistry, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, UK

    M. Giulia Bigotti, Anthony R. Clarke & Steven G. Burston

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  1. M. Giulia Bigotti
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  2. Anthony R. Clarke
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Ineke Braakman

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Bigotti, M.G., Clarke, A.R., Burston, S.G. The Hsp60 chaperonins from prokaryotes and eukaryotes. In: Braakman, I. (eds) Chaperones. Topics in Current Genetics, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/4735_116

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