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Senescence and Cell Cycle Control

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Cell Cycle Regulation

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 42))

Abstract

In response to various stresses, such as telomere shortening during continuous proliferation, oxidative stress, DNA damage and aberrant oncogene activation, normal cells undergo cellular senescence, which is a stable postmitotic state with particular morphology and metabolism. Signaling that induces senescence involves two major tumor suppressor cascades, i.e., the INK4a-Rb pathway and the ARF-p53 pathway. Diverse stimuli upregulate these interacting pathways, which orchestrate exit from the cell cycle. Recent studies have provided insights into substantial differences in senescence-inducing signals in primary cells of human and rodent origins. This review is focused on recent advances in understanding the roles of the tumor-suppressive pathways in senescence.

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Acknowledgments

I apologize to many colleagues for being unable to cite their papers critical for the field. I thank Nissim Hay, Rob Costa, Pradip Raychaudhuri, Oscar Colamonici, David Ucker and Xianghong Zou for helpful discussions, and the National Institutes of Health, the Department of Defense and the American Cancer Society for grant support for my research.

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  1. Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Avenue, 60611, Chicago, IL, USA

    Hiroaki Kiyokawa

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Philipp Kaldis

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Kiyokawa, H. Senescence and Cell Cycle Control. In: Kaldis, P. (eds) Cell Cycle Regulation. Results and Problems in Cell Differentiation, vol 42. Springer, Berlin, Heidelberg. https://doi.org/10.1007/400_001

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