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Engagement of Proinflammatory Cytokines after Cerebral Ischemia

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Breathing, Feeding, and Neuroprotection

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Summary

The incidence of stroke is gradually increasing in the industrialized world and a major cause of long-lasting disability. To determine the mechanism of neuronal cell death after stroke and develop the new strategy of therapy, several studies had been performed during the past decade and some proinflammatory cytokines were identified as the therapeutic candidate. However, the critical actions of proinflammatory cytokines are still largely unknown in detail because the cytokines play a role on small amount, show the short half-life, and have multiple functions for depending on the amount and time of expression. We present here the pathophysiological events of cerebral ischemia and the action and possibility of proinflammatory cytokines from the recent results.

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Authors and Affiliations

  1. Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan

    Hirokazu Ohtaki, Li Yin, Kenji Dohi, Sachiko Yofu, Tomoya Nakamachi & Seiji Shioda

  2. Emergency and Clinical Care Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan

    Kenji Dohi

  3. Gene Trophology Research Institute, Tokyo, 130-0012, Japan

    Sachiko Yofu & Masaji Matsunaga

Authors
  1. Hirokazu Ohtaki
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  2. Li Yin
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  3. Kenji Dohi
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  4. Sachiko Yofu
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  5. Tomoya Nakamachi
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  6. Masaji Matsunaga
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  7. Seiji Shioda
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Editor information

Editors and Affiliations

  1. Department of Physiology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan

    Ikuo Homma M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

  2. Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan

    Seiji Shioda M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

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© 2006 Springer-Verlag Tokyo

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Ohtaki, H. et al. (2006). Engagement of Proinflammatory Cytokines after Cerebral Ischemia. In: Homma, I., Shioda, S. (eds) Breathing, Feeding, and Neuroprotection. Springer, Tokyo. https://doi.org/10.1007/4-431-28775-2_6

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