Abstract
It is established in the animal models that cerebral cytokine overproduction is involved the subsequent neuronal death after traumatic brain injury (TBI) [ 1,2]. Such cytokine surge after TBI could be inhibited by induced hypothermia in the animal, leading to improvement in the neurological outcome [1,2]. However, in the clinical setting of induced hypothermia, cytokine responses or even neuroprotective effects remain controversial. On the other, we have demonstrated that in accidental hypothermia even activated cytokine production occurs [3]. Objective of this review is to discuss potential mechanisms for controversies over the neuroprotection of induced hypothermia for TBI patients.
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© 2006 Springer-Verlag Tokyo
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Aibiki, M. (2006). Different Cytokine Responses between Induced and Accidental Hypothermia: An Implication for Controversies over Neuroeffective of Therapeutic Hypothermia. In: Kanno, T., Kato, Y. (eds) Minimally Invasive Neurosurgery and Multidisciplinary Neurotraumatology. Springer, Tokyo. https://doi.org/10.1007/4-431-28576-8_51
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DOI: https://doi.org/10.1007/4-431-28576-8_51
Publisher Name: Springer, Tokyo
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