Hemodynamic Efficacy of Neuroleptanesthesia for Therapeutic Hypothermia in Acute Brain Injury

Abstract

We have performed a retrospective review of 18 patients with acute brain injury who had therapeutic mild hypothermia. The patients were divided into two groups by anesthesia: droperidol & fentanyl (NLA group), and midazolam & butorphanol (MB group). To induce and maintain mild hypothermia, patients were cooled by a blanket and a mat with circulating cool water. The target core temperature was 32 to 34C. To maintain microcirculation, colloid solution and/or dobutamine were used. We inserted a pulmonary artery catheter in all the patients and measured the hemodynamic parameters (Table 1) at induction phase and maintenance phase of therapeutic mild hypothermia. The doses of anesthetic agents in each group are shown in Table 2.