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Regeneration of Myocardium Using Bone Marrow Cells

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Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches

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Summary

Bone marrow cells are advantageous for exogenous cell transplantation to treat end-stage heart failure regard to autologous source, no ethical issue, capacity to regenerate myocardium, induction of angiogenesis. Based on basic research showing regenerating myocardium using bone marrow, clinical trials in several places were conducted like gold rush in recent years. Endogenous-stem cell therapy may be also a promising strategy. Self-renewal of myocardium may be partly derived from bone marrow and the myocardium itself, which was thought to be a terminally differentiated organ. The past new technologies have been developed and their use expanded despite a lack of concrete evidence regarding their effectiveness. However, we still have a lot of unanswered questions including optimal cell population, cell density, and exact mechanism responsible for the improvement of cardiac dysfunction, fate of fusioned cells, cardiac environmental factors, regulation of proliferation and differentiation of transplanted cells, efficient cell tracking method in human. People involved in this field must be careful as they proceed, as inappropriately designed research might ruin the future of the field of regenerative medicine. Cell-based therapy will continue to expand at a rapid rate over the next decade. Whether the benefits of cell-based therapy are evident in the future remains to be seen.

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Authors and Affiliations

  1. Cardiothoracic Surgical Unit, Auckland City Hospital, Auckland, New Zealand

    Shinji Tomita

  2. Department of Organ Transplantation, National Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan

    Takeshi Nakatani

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  1. Shinji Tomita
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  2. Takeshi Nakatani
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Editors and Affiliations

  1. Department of Cardiac Physiology, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka, 565-8565, Japan

    Hidezo Mori M.D., Ph.D. (Director) (Director)

  2. Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, 2-2-El Yamadaoka, Suita, Osaka, 565-0871, Japan

    Hikaru Matsuda M.D., Ph.D. (Professor) (Professor)

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© 2005 Springer-Verlag Tokyo

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Tomita, S., Nakatani, T. (2005). Regeneration of Myocardium Using Bone Marrow Cells. In: Mori, H., Matsuda, H. (eds) Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches. Springer, Tokyo. https://doi.org/10.1007/4-431-27378-6_3

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  • DOI: https://doi.org/10.1007/4-431-27378-6_3

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-23925-3

  • Online ISBN: 978-4-431-27378-3

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