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Metabolism of steroids in plant tissue cultures

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Advances in Biochemical Engineering, Volume 16

Part of the book series: Advances in Biochemical Engineering ((ABE,volume 16))

Abstract

In the following article the current knowledge regarding the metabolism of steroids by cultured plant cells will be described. the various types of steroid biotransformation reactions which have been reported for plant tissue cultures will be reviewed. furthermore, since many plant cell cultures are totipotent, that is, they possess all the information necessary for the replication and functioning of the whole plant, transformation reactions of potential industrial or scientific significance have also been described for some plants, further demonstrating the utility of plant tissue cultures. the results presented demonstrate that suspension cultures of plant cells can effect a wide-range of steroidal transformation reactions, several with industrial applicability.

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Abbreviations

2,4-D:

2,4-dichlorophenoxyacetic acid

NADP+:

Nicotinamide adenine dinucleotide phosphate

NADPH:

Nicotinamide adenine dinucleotide phosphate, reduced

NADH:

Nicotinamide adenine dinucleotide, reduced

6 References

  1. Stohs, S. J., Rosenberg, H.: Lloydia 38, 181 (1975)

    Google Scholar 

  2. Stohs, S. J., In: Plant Tissue Culture and its Bio-Technological Application. Bartz, W., Reinhard, E., Zenk, M. H. (Eds), p. 142. Berlin, Springer 1977

    Google Scholar 

  3. Overton, K. W., Picken, D. J.: In: Progress in the Chemistry of Organic Natural Products. Herz, W., Gresebach, H., Kirby, G. W., (Eds), Vol. 34, p. 249. Berlin, Springer 1977

    Google Scholar 

  4. In: Plant Tissue Culture as a Source of Biochemicals. Staba, E. J., (Ed.). Cleveland, Chemical Rubber Company 1979

    Google Scholar 

  5. In: Production of Natural Compounds by Cell Culture Methods, Proc. Internat. Sympos. Plant Cell Culture: A. W. Alfermann, I. Reinhard (Eds.). München, Ges. Strahlen-u. Umweltforsch. 1978

    Google Scholar 

  6. Charney, W., Herzog, H. L.: Microbiol. Transformations of Steroids-A Handbook, New York, Academic Press 1967

    Google Scholar 

  7. Iizuki, H., Naito, A.: Microbial Transformations of Steroids and Alkaloids, Tokyo, University of Tokyo Press and University Park Press 1967

    Google Scholar 

  8. Heins, M., Wahl, J., Lerch, H., Kaiser, F., Reinhard, E.: Planta Med. 33, 57 (1978)

    Google Scholar 

  9. Murashige, T., Skoog, F.: Physiol. Plant 15, 473 (1962)

    Google Scholar 

  10. White, P. R.: The cultivation of Animal and Plant Cells. New York, The Ronald Press Co. 1954

    Google Scholar 

  11. Heller, R.: Ann. Sci. Nat. Bot. Biol. Veg. Paris 14, 1 (1953)

    Google Scholar 

  12. Nitsch, J. P., Nitsch, C: Science 163, 85 (1969)

    Google Scholar 

  13. Kaul, B., Staba, E. J.: Lloydia 31, 171 (1968)

    Google Scholar 

  14. Khanna, P., Staba, E. J.: Lloydia 31, 180 (1968)

    Google Scholar 

  15. Staba, E. J.: Rec. Adv. Phytochem. 2, 75 (1969)

    Google Scholar 

  16. Stohs, S. J., El-Olemy, M. M.: Lloydia 35, 81 (1972)

    Google Scholar 

  17. Hirotani, M., Furuya, T.: Phytochem. 14, 2601 (1975)

    Google Scholar 

  18. Tomita, Y., Uomori, A.: Phytochem. 13, 729 (1974)

    Google Scholar 

  19. Yagen, B., Gallili, G. E., Mateles, R. I.: Appl. Environ. Microbiol. 36, 213 (1978)

    Google Scholar 

  20. Weber, N.: Z. Pflanzenphysiol. Bd. 87, 355 (1978)

    Google Scholar 

  21. Kaul, B., Stohs, S. J., Staba, E. J.: Lloydia 32, 347 (1969)

    Google Scholar 

  22. Jones, A., Veliky, I. A., Ozubko, R. S.: Lloydia 41, 476 (1978)

    Google Scholar 

  23. Stohs, S. J., El-Olemy, M. M.: Phytochem. 11, 1397 (1972)

    Google Scholar 

  24. Stohs, S. J., Kaul, B., Staba, E. J.: Phytochem. 8, 1679 (1969)

    Google Scholar 

  25. Stohs, S. J., Sabatka, J. J., Rosenberg, H.: Phytochem. 13, 2145 (1974)

    Google Scholar 

  26. Mandels, M.: Adv. Biochem. Eng. 2, 202 (1972)

    Google Scholar 

  27. Stohs, S. J., unpublished

    Google Scholar 

  28. Graebe, J. E., Novelli, G. D.: Exp. Cell Res. 41, 509 (1966)

    Google Scholar 

  29. Wang, C. J., Staba, E. J.: J. Pharm. Sci. 52, 1058 (1963)

    Google Scholar 

  30. Radwan, S. S., Mangold, H. K.: Adv. Lipid Res. 16, 171 (1975)

    Google Scholar 

  31. Radwan, S. S., Mangold, H. K.: Chem. Phys. Lipids 14, 87 (1975)

    Google Scholar 

  32. Radwan, S. S., Spener, F., Mangold, H. K., Staba, E. J.: Chem. Phys. Lipids 14, 72 (1975)

    Google Scholar 

  33. Puhan, Z., Martin, S. M.: Prof. Ind. Microbiol. 9, 13 (1971)

    Google Scholar 

  34. Furuya, T., Hirotani, M., Kawaguchi, K.: Phytochem. 10, 1013 (1971)

    Google Scholar 

  35. Hirotani, M., Furuya, T.: Phytochem. 13, 2135 (1974)

    Google Scholar 

  36. Coon, M. J., Strobel, H. W., Boyer, R. F.: Drug Metab. Disp. 1, 92 (1973)

    Google Scholar 

  37. Young, O., Beevers, H.: Phytochem. 15, 379 (1976)

    Google Scholar 

  38. Meehan, T. D., Coscia, C. J.: Biochem. Biophys. Res. Commun. 55, 1043 (1973)

    Google Scholar 

  39. Rich, P. R., Lamb, C. J.: Eur. J. Biochem. 72, 353 (1977)

    Google Scholar 

  40. Trenck, K. T. v. d., Sandermann, H.: Planta 141, 245 (1978)

    Google Scholar 

  41. Harms, H., Dehnen, W., Monch, W.: Z. Naturforsch. 32, 321 (1977)

    Google Scholar 

  42. DePierre, J. W., Ernster, L.: Biochim. Biophys. Acta 473, 149 (1978)

    Google Scholar 

  43. Tomita, Y., Uomori, A., Minato, H.: Phytochem. 9, 111 (1970)

    Google Scholar 

  44. Tomita, Y., Uomori, A.: Chem. Commun. 1971, 284

    Google Scholar 

  45. Panova, D., Nikoloff, S., Achtardjieff, C: Planta Med. 26, 90 (1974)

    Google Scholar 

  46. Jewers, K., Burbage, M. B.: Steroids 24, 203 (1974)

    Google Scholar 

  47. Takeda, K., Okanishi, T., Minato, M., Shimaoka, A.: Tetrahedron 21, 2089 (1965)

    Google Scholar 

  48. Takeda, K., Okanishi, T., Minato, M., Shimaoka, A.: Tetrahedron 19, 759 (1963)

    Google Scholar 

  49. Heftmann, E.: Lipids 9, 626 (1974)

    Google Scholar 

  50. Wall, M. E., Eddy, C. R., Serota, S., Mininger, R. F.: J. Amer. Chem. Soc. 75, 4437 (1953)

    Google Scholar 

  51. Marker, R. E., Wagner, R. B., Ulshafer, P. R., Wittbecker, E. L., Goldsmith, D. P. J., Ruof, C. H.: J. Amer. Chem. Soc. 69, 2167 (1947)

    Google Scholar 

  52. Akahori, A.: Ann. Rep. Shionogi Res. Lab. 11, 93 (1961)

    Google Scholar 

  53. Akahori, A.: Phytochem. 4, 97 (1965)

    Google Scholar 

  54. Imai, S., Toyosato, T., Sakai, M., Sato, Y., Fujioka, S., Murata, E., Goto, M.: Chem. Pharm. Bull. 17, 335 (1969)

    Google Scholar 

  55. Stohs, S. J., Sabatka, J. J., Obrist, J. J., Rosenberg, H.: Lloydia 37, 504 (1974)

    Google Scholar 

  56. Tomita, Y., Seo, S.: J. Chem. Soc. Chem. Commun. 1973, 707

    Google Scholar 

  57. Wall, M. E., Krider, M. M., Krewson, C. F., Eddy, C. R., Willaman, J. J., Corell, D. S., Gentry, H. S.: J. Amer. Pharm. Assoc. 43, 1 (1954)

    Google Scholar 

  58. Takeda, K.: Chem. Pharm. Bull. 9, 631 (1961)

    Google Scholar 

  59. Kimura, M., Tohma, M., Yoshizawa, I.: Chem. Pharm. Bull. 15, 1713 (1967)

    Google Scholar 

  60. Sauer, H. H., Bennett, R. D., Heftmann, E.: Phytochem. 7, 1543 (1968)

    Google Scholar 

  61. Tschesche, R., Brassat, B.: Z. Naturforsch. 20b, 707 (1965)

    Google Scholar 

  62. Golab, T., Trabert, C, Jager, H., Reichstein, T.: Helv. Chem. Acta 42, 2418 (1959)

    Google Scholar 

  63. Lee, P. K., Carew, D. P., Rosazza, J.: Lloydia 35, 150 (1972)

    Google Scholar 

  64. Furuya, T., Kojima, H., Syono, K., Ishii, T., Uotani, K., Nishio, M.: Chem. Pharm. Bull. 21, 98 (1973)

    Google Scholar 

  65. Weber, N.: Phytochem 16, 1849 (1977)

    Google Scholar 

  66. Itokawa, H., Akasu, M., Fujita, M.: Chem. Pharm. Bull. 21, 1386 (1973)

    Google Scholar 

  67. Teng, J. I., Smith, L. L.: J. Steroid Biochem. 7, 577 (1976)

    Google Scholar 

  68. Nair, M. G., Chang, F. C. Phytochem. 12, 903 (1973)

    Google Scholar 

  69. Ripperger, H., Schreiber, K., Budzikiewicz, H.: Chem. Ber. 100, 1741 (1967)

    Google Scholar 

  70. Elzie, H., Pilgrim, H., Teuscher, E.: Pharmazie 29, 10 (1974)

    Google Scholar 

  71. Barreira, R. F., Gonzalez, A. G., Rocio, J. A. S., Lopez, E. S.: Phytochem. 9, 1641 (1970)

    Google Scholar 

  72. Reinhard, E., Boy, M., Kaiser, F.: Planta Med. Suppl. 1975, 163

    Google Scholar 

  73. Gonzalez, A. G., Barreira, R. F., Gonzalez, R. H., Salazar, J. A., Lopez. E. S.: Quimica 68, 309 (1972)

    Google Scholar 

  74. El-Olemy, M. M., Sabatka, J. J., Stohs, S. J.: Phytochem. 13, 489 (1974)

    Google Scholar 

  75. Blunden, G., Hardman, R. Phytochem. 8, 1523 (1969)

    Google Scholar 

  76. Kenney, H. D., Wall, M. E.: J. Org. Chem. 22, 468 (1957)

    Google Scholar 

  77. Heftmann, E.: Lipids 6, 128 (1971)

    Google Scholar 

  78. Uomori, A., Seo, S., Tomita, Y.: Syoyakugaku Zasshi 28, 152 (1974)

    Google Scholar 

  79. Tschesche, R.: Roc. Roy. Soc. Lond. B. 180, 187 (1972)

    Google Scholar 

  80. Furuya, T., Hirotani, M., Shinohara, T.: Chem. Pharm. Bull. 18, 1080 (1970)

    Google Scholar 

  81. Talalay, P.: In: The Enzymes. P. D. Boyer, H. Lardy, K. Myrback (Eds), Vol. 7, p. 177. New York, Academic Press 1963

    Google Scholar 

  82. Graves, J. M. H., Smith. W. K.: Nature 214, 1248 (1967)

    Google Scholar 

  83. Stohs, S. J., El-Olemy, M. M.: Phytochem. 11, 2409 (1972)

    Google Scholar 

  84. Sauer, H. H., Bennett, R. D., Heftmann, E.: Phytochem. 6, 1521 (1967)

    Google Scholar 

  85. Caspi, E., Lewis, D. O.: Science 214, 519 (1967)

    Google Scholar 

  86. Furuya, T., Kawaguchi, K., Hirotani, M: Phytochem. 12, 1621 (1973

    Google Scholar 

  87. Stohs, S. J.: Phytochem. 14, 2419 (1975)

    Google Scholar 

  88. Stohs, S. J., El-Olemy, M. M.: J. Steroid Biochem. 2, 293 (1971)

    Google Scholar 

  89. Stohs, S. J., El-Olemy, M. M.: Phytochem. 10, 2987 (1971)

    Google Scholar 

  90. Stohs, S. J., Staba, E. J.: J. Pharm. Sci. 54, 56 (1965)

    Google Scholar 

  91. Tschesche, R., Hombach, R., Scholten, H., Peters, M.: Phytochem. 9, 1505 (1970)

    Google Scholar 

  92. Johnson, D. F., Waters, J. A., Bennett, R. D.: Arch. Biochem. Biophys. 108, 282 (1964)

    Google Scholar 

  93. Stohs, S. J.: Phytochem. 8, 1215 (1969)

    Google Scholar 

  94. Bennett, R. D., Sauer, H. H., Heftmann, E.: Phytochem. 7, 41 (1968)

    Google Scholar 

  95. Stohs, S. J. Haggerty, J. A.: Phytochem. 12, 2869 (1973)

    Google Scholar 

  96. Hitchcock, C, Nichols, B. W., In: Plant Lipid Biochemistry, p. 51. New York, Academic Press 1971

    Google Scholar 

  97. Hardman, R.: Trop. Sci. 11, 196 (1969)

    Google Scholar 

  98. Pilgrim, H.: Phytochem. 11, 1725 (1972)

    Google Scholar 

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Authors and Affiliations

  1. Department of Biomedicinal Chemistry, College of Pharmacy, University of Nebraska Medical Center, 68105, Omaha, Nebraska, USA

    S. J. Stohs

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  1. S. J. Stohs
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A. Fiechter

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© 1980 Springer-Verlag

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Stohs, S.J. (1980). Metabolism of steroids in plant tissue cultures. In: Fiechter, A. (eds) Advances in Biochemical Engineering, Volume 16. Advances in Biochemical Engineering, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3540098070_9

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  • DOI: https://doi.org/10.1007/3540098070_9

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  • Print ISBN: 978-3-540-09807-2

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