Skip to main content
SpringerLink
Log in

Risk identification and management: MRI as a research tool in toxicology studies of new chemical entities

  • Chapter
Imaging in Drug Discovery and Early Clinical Trials

Part of the book series: Progress in Drug Research ((PDR,volume 62))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Spoor F, Jeffery N, Zonneveld F (2000) Using diagnostic radiology in human evolutionary studies. J Anat 197: 61–76

    Article  PubMed  Google Scholar 

  2. Halvorsen RA, Jr., Yee J, McCormick VD (1996) Diagnosis and staging of gastric cancer. Semin Oncol 23: 325–335

    PubMed  Google Scholar 

  3. Woodard PK, Dehdashti F, Putman CE (1998) Radiologic diagnosis of extrathoracic metastases to the lung. Oncology (Huntington) 12: 431–438

    CAS  Google Scholar 

  4. Nagashima T, Suzuki M, Yagata H, Hashimoto H, Shishikura T, Imanaka N, Ueda T, Miyazaki M (2002) Dynamic-enhanced MRI predicts metastatic potential of invasive ductal breast cancer. Breast Cancer 9: 226–230

    PubMed  Google Scholar 

  5. Kim SG, Ogawa S (2002) Insights into new techniques for high resolution functional MR. Curr Opin Neurobiol 12: 607–615

    Article  PubMed  CAS  Google Scholar 

  6. Miller DH, Barkhof F, Frank JA, Parker GJ, Thompson AJ (2002) Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevance. Brain 125: 1676–1695

    Article  PubMed  Google Scholar 

  7. Caviness VS, Jr., Lange NT, Makris N, Herbert MR, Kennedy DN (1999) MRI-based brain volumetrics: emergence of a developmental brain science. Brain Dev 21: 289–295

    PubMed  Google Scholar 

  8. Lawrie SM, Abukmeil SS (1998) Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies. Br J Psychiatry 172: 110–120

    Article  PubMed  CAS  Google Scholar 

  9. Belozerova I, Shenkman B, Mazin M, Leblanc A (2001) Effects of long-duration bed rest on structural compartments of m. soleus in man. J Gravit Physiol 8: P71–P72

    PubMed  CAS  Google Scholar 

  10. Cockman MD, Jones MB, Prenger MC, Sheldon RJ (2001) Magnetic resonance imaging of denervation-induced muscle atrophy: effects of clenbuterol in the rat. Muscle Nerve 24: 1647–1658

    Article  PubMed  CAS  Google Scholar 

  11. di Cesare E (2003) MRI assessment of right ventricular dysplasia. Eur Radiol 13: 1387–1393

    PubMed  Google Scholar 

  12. Sato M, Yagasaki T, Kora T, Awaya S (1998) Comparison of muscle volume between congenital and acquired superior oblique palsies by magnetic resonance imaging. Jpn J Ophthalmol 42: 466–470

    PubMed  CAS  Google Scholar 

  13. Nikolaou K, Poon M, Sirol M, Becker CR, Fayad ZA (2003) Complementary results of computed tomography and magnetic resonance imaging of the heart and coronary arteries: a review and future outlook. Cardiol Clin 21: 639–655

    Article  PubMed  Google Scholar 

  14. Saeed M (2001) New concepts in characterization of ischemically injured myocardium by MRI. Exp Biol Med 226: 367–376

    CAS  Google Scholar 

  15. Hanni M, Lekka-Banos I, Nilsson S, Haggroth L, Smedby O (1999) Quantitation of atherosclerosis by magnetic resonance imaging and 3-D morphology operators. Magn Reson Imaging 17: 585–591

    PubMed  CAS  Google Scholar 

  16. Ruehm SG, Corot C, Vogt P, Kolb S, Debatin JF (2001) Magnetic resonance imaging of atherosclerotic plaque with ultrasmall superparamagnetic particles of iron oxide in hyperlipidemic rabbits. Circulation 103: 415–422

    PubMed  CAS  Google Scholar 

  17. Hockings PD, Roberts T, Galloway GJ, Reid DG, Harris DA, Vidgeon-Hart M, Groot PH, Suckling KE, Benson GM (2002) Repeated three-dimensional magnetic resonance imaging of atherosclerosis development in innominate arteries of low-density lipoprotein receptor-knockout mice. Circulation 106: 1716–1721

    Article  PubMed  CAS  Google Scholar 

  18. Peterfy CG (1996) MR imaging. Baillieres Clinical Rheumatology 10: 635–678

    CAS  Google Scholar 

  19. Logothetis NK (2002) The neural basis of the blood-oxygen-level-dependent functional magnetic resonance imaging signal. Phil Trans R Soc Lond 357: 1003–1037

    Google Scholar 

  20. Detre JA, Wang J (2002) Technical aspects and utility of fMRI using BOLD and ASL. Clin Neurophysiol 113: 621–634

    Article  PubMed  Google Scholar 

  21. Mullins PG, Reid DG, Hockings PD, Hadingham SJ, Campbell CA, Chalk JB, Doddrell DM (2001) Ischaemic preconditioning in the rat brain: a longitudinal magnetic resonance imaging (MRI) study. NMR in Biomedicine 14: 204–209

    Article  PubMed  CAS  Google Scholar 

  22. Volz HP, Gaser C, Hager F, Rzanny R, Mentzel HJ, Kreitschmann-Andermahr I, Kaiser WA, Sauer H (1997) Brain activation during cognitive stimulation with the Wisconsin Card Sorting Test—a functional MRI study on healthy volunteers and schizophrenics. Psychiatry Res 75: 145–157

    PubMed  CAS  Google Scholar 

  23. Sinha S, Sinha U (2002) Functional magnetic resonance of human breast tumors: diffusion and perfusion imaging. Ann NY Acad Sci 980: 95–115

    PubMed  Google Scholar 

  24. Huber P, Peschke P, Brix G, Hahn EW, Lorenz A, Tiefenbacher U, Wannenmacher M, Debus J (1999) Synergistic interaction of ultrasonic shock waves and hyperthermia in the Dunning prostate tumor R3327-AT1. Int J Cancer 82: 84–91

    Article  PubMed  CAS  Google Scholar 

  25. Huisman TA (2003) Diffusion-weighted imaging: basic concepts and application in cerebral stroke and head trauma. Eur Radiol 13: 2283–2297

    Article  PubMed  Google Scholar 

  26. Miller DH, Filippi M, Fazekas F, Frederiksen JL, Matthews PM, Montalban X, Polman CH (2004) Role of magnetic resonance imaging within diagnostic criteria for multiple sclerosis. Ann Neurol 56: 273–278

    PubMed  CAS  Google Scholar 

  27. Weinmann HJ, Ebert W, Misselwitz B, Schmitt-Willich H (2003) Tissue-specific MR contrast agents. Eur J Radiol 46: 33–44

    Article  PubMed  Google Scholar 

  28. Pearlman JD, Laham RJ, Post M, Leiner T, Simons M (2002) Medical imaging techniques in the evaluation of strategies for therapeutic angiogenesis. Curr Pharm Des 8: 1467–1496

    Article  PubMed  CAS  Google Scholar 

  29. Kluge A, Dill T, Ekinci O, Hansel J, Hamm C, Pitschner HF, Bachmann G (2004) Decreased pulmonary perfusion in pulmonary vein stenosis after radiofrequency ablation: assessment with dynamic magnetic resonance perfusion imaging. Chest 126: 428–437

    PubMed  Google Scholar 

  30. Baer FM, Theissen P, Schneider CA, Kettering K, Voth E, Sechtem U, Schicha H (1999) MRI assessment of myocardial viability: comparison with other imaging techniques. Rays 24: 96–108

    PubMed  CAS  Google Scholar 

  31. Botnar RM, Perez AS, Witte S, Wiethoff AJ, Laredo J, Hamilton J, Quist W, Parsons EC, Jr, Vaidya A, Kolodziej A et al. (2004) In vivo molecular imaging of acute and subacute thrombosis using a fibrin-binding magnetic resonance imaging contrast agent. Circulation 109: 2023–2029

    Article  PubMed  CAS  Google Scholar 

  32. Barber PA, Foniok T, Kirk D, Buchan AM, Laurent S, Boutry S, Muller RN, Hoyte L, Tomanek B, Tuor UI (2004) MR molecular imaging of early endothelial activation in focal ischemia. Ann Neurol 56: 116–120

    Article  PubMed  CAS  Google Scholar 

  33. Artemov D (2003) Molecular magnetic resonance imaging with targeted contrast agents. J Cell Biochem 90: 518–524

    Article  PubMed  CAS  Google Scholar 

  34. Shapiro EM, Skrtic S, Sharer K, Hill JM, Dunbar CE, Koretsky AP (2004) MRI detection of single particles for cellular imaging. Proc Natl Acad Sci USA 101: 10901–10906

    Article  PubMed  CAS  Google Scholar 

  35. Moffat BA, Reddy GR, McConville P, Hall DE, Chenevert TL, Kopelman RR, Philbert M, Weissleder R, Rehemtulla A, Ross BD (2003) A novel polyacrylamide magnetic nanoparticle contrast agent for molecular imaging using MRI. Mol Imaging 2: 324–332

    Article  PubMed  CAS  Google Scholar 

  36. Hockings PD, Roberts T, Campbell SP, Reid DG, Greenhill RW, Polley SR, Nelson P, Bertram TA, Kramer K (2002) Longitudinal magnetic resonance imaging quantitation of rat liver regeneration after partial hepatectomy. Toxicol Pathol 30: 606–610

    Article  PubMed  Google Scholar 

  37. Lee BC, Mintun M, Buckner RL, Morris JC (2003) Imaging of Alzheimer’s disease. J Neuroimaging 13: 199–214

    PubMed  Google Scholar 

  38. Fuchs VR, Sox HC Jr (2001) Physicians’ views of the relative importance of thirty medical innovations. Health Affairs 20: 30–42

    Article  PubMed  CAS  Google Scholar 

  39. Awaya H, Ito K, Honjo K, Fujita T, Matsumoto T, Matsunaga N (1998) Differential diagnosis of hepatic tumors with delayed enhancement at gadolinium-enhanced MRI: a pictorial essay. Clin Imaging 22: 180–187

    PubMed  CAS  Google Scholar 

  40. Murakami T, Mochizuki K, Nakamura H (2001) Imaging evaluation of the cirrhotic liver. Semin Liver Dis 21: 213–224

    Article  PubMed  CAS  Google Scholar 

  41. Beutler E, Hoffbrand AV, Cook JD (2003) Iron deficiency and overload. Hematology: 40–61

    Google Scholar 

  42. Mortele KJ, Ros PR (2001) Imaging of diffuse liver disease. Semin Liver Dis 21: 195–212

    Article  PubMed  CAS  Google Scholar 

  43. Hockings PD, Changani KK, Saeed N, Reid DG, Birmingham J, O’Brien P, Osborne J, Toseland CN, Buckingham RE (2003) Rapid reversal of hepatic steatosis, and reduction of muscle triglyceride, by rosiglitazone: MRI/S studies in Zucker fatty rats. Metabolism 5: 234–243

    CAS  Google Scholar 

  44. Zhang X, Tengowski M, Fasulo L, Botts S, Suddarth SA, Johnson GA (2004) Measurement of fat/water ratios in rat liver using 3D three-point dixon MRI. Magn Reson Med 51: 697–702

    PubMed  Google Scholar 

  45. Dixon WT (1984) Simple proton spectroscopic imaging. Radiology 153: 189–194

    PubMed  CAS  Google Scholar 

  46. Glover GH (1991) Multipoint Dixon technique for water and fat proton and susceptibility imaging. J Magn Reson Imaging 1: 521–530

    PubMed  CAS  Google Scholar 

  47. Glover GH, Schneider E (1991) Three-point Dixon technique for true water/fat decomposition with B0 inhomogeneity correction. Magn Reson Med 18: 371–383

    PubMed  CAS  Google Scholar 

  48. Rudolph U, Mohler H (2004) Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics. Ann Rev Pharmacol Toxicol 44: 475–498

    Article  CAS  Google Scholar 

  49. Vacher CM, Bettler B (2003) GABA(B) receptors as potential therapeutic targets. Curr Drug Target CNS Neurol Disord 2: 248–259

    CAS  Google Scholar 

  50. Johnston GA, Chebib M, Hanrahan JR, Mewett KN (2003) GABA(C) receptors as drug targets. Curr Drug Target CNS Neurol Disord 2: 260–268

    CAS  Google Scholar 

  51. Aragon C, Lopez-Corcuera B (2003) Structure, function and regulation of glycine neurotransporters. Eur J Pharmacol 479: 249–262

    PubMed  CAS  Google Scholar 

  52. Sonnewald U, Qu H, Aschner M (2002) Pharmacology and toxicology of astrocyte-neuron glutamate transport and cycling. J Pharm Exp Ther 301: 1–6

    Article  CAS  Google Scholar 

  53. Grant SM, Heel RC (1991) Vigabatrin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy and disorders of motor control. Drugs 41: 889–926

    Article  PubMed  CAS  Google Scholar 

  54. Sabers A, Gram L (1992) Pharmacology of vigabatrin. Pharmacol Toxicol 70: 237–243

    Article  PubMed  CAS  Google Scholar 

  55. Schechter PJ (1989) Clinical pharmacology of vigabatrin. Brit J Clin Pharmacol 27: 19S–22S

    CAS  Google Scholar 

  56. Summers BA, Cummings JF, de Lahunta A (1995) Hereditary, familial, and idiopathic degenerative diseases. In: N Coon (ed): Veterinary Neuropathology, Mosby-Year Book, Inc., St. Louis, 281–350

    Google Scholar 

  57. Malm G, Ringden O, Winiarski J, Grondahl E, Uyebrant P, Eriksson U, Hakansson H, Skjeldal O, Mansson JE (1996) Clinical outcome in four children with metachromatic leukodystrophy treated by bone marrow transplantation. Bone Marrow Transplant 17: 1003–1008

    PubMed  CAS  Google Scholar 

  58. Matsuyama W, Kuriyama M, Nakagawa M, Kanazawa H, Takenaga S, Ijichi S, Osame M (1996) Choroideremia with leukoencephalopathy and arylsulfatase A pseudodeficiency. J Neurol Sci 138: 161–164

    Article  PubMed  CAS  Google Scholar 

  59. Barkhof F, Scheltens P (2002) Imaging of white matter lesions. Cerebrovasc Dis 13: 21–30

    Article  PubMed  Google Scholar 

  60. Jackson GD, Williams SR, Weller RO, van Bruggen N, Preece NE, Williams SC, Butler WH, Duncan JS (1994) Vigabatrin-induced lesions in the rat brain demonstrated by quantitative magnetic resonance imaging. Epilepsy Res 18: 57–66

    PubMed  CAS  Google Scholar 

  61. Preece NE, Houseman J, King MD, Weller RO, Williams SR (2004) Development of vigabatrin-induced lesions in the rat brain studied by magnetic resonance imaging, histology, and immunocytochemistry. Synapse 53: 36–43

    Article  PubMed  CAS  Google Scholar 

  62. Weiss KL, Schroeder CE, Kastin SJ, Gibson JP, Yarrington JT, Heydorn WE, McBride RG, Sussman NM, Arezzo JC (1994) MRI monitoring of vigabatrin-induced intramyelinic edema in dogs. Neurology 44: 1944–1949

    PubMed  CAS  Google Scholar 

  63. Peyster RG, Sussman NM, Hershey BL, Heydorn WE, Meyerson LR, Yarrington JT, Gibson JP (1995) Use of ex vivo magnetic resonance imaging to detect onset of vigabatrininduced intramyelinic edema in canine brain. Epilepsia 36: 93–100

    Article  PubMed  CAS  Google Scholar 

  64. Agosti R, Yasargil G, Egli M, Wieser HG, Wiestler OD (1990) Neuropathology of a human hippocampus following long-term treatment with vigabatrin: lack of microvacuoles. Epilepsy Res 6: 166–170

    Article  PubMed  CAS  Google Scholar 

  65. Cohen JA, Fisher RS, Brigell MG, Peyster RG, Sze G (2000) The potential for vigabatrininduced intramyelinic edema in humans. Epilepsia 41: 148–157

    Article  PubMed  CAS  Google Scholar 

  66. Vallee JP, Lazeyras F, Khan HG, Terrier F (2000) Absolute renal blood flow quantification by dynamic MRI and Gd-DTPA. Eur Radiol 10: 1245–1252

    PubMed  CAS  Google Scholar 

  67. Pedersen M, Shi Y, Anderson P, Stodkilde-Jorgensen H, Djurhuus JC, Gordon I, Frokiaer J (2004) Quantitation of differential renal blood flow and renal function using dynamic contrast-enhanced MRI in rats. Magn Reson Med 51: 510–517

    Article  PubMed  Google Scholar 

  68. Kobayashi H, Kawamoto S, Jo SK, Sato N, Saga T, Hiraga A, Konishi J, Hu S, Togashi K, Brechbiel MW, Star RA (2002) Renal tubular damage detected by dynamic micro-MRI with a dendrimer-based magnetic resonance contrast agent. Kidney Int 61: 1980–1985

    Article  PubMed  Google Scholar 

  69. Hedlund LW, Maronpot RR, Johnson GA, Cofer GP, Mills GI, Wheeler CT (1991) Magnetic resonance microscopy of toxic renal injury induced by bromoethylamine in rats. Fundam Appl Toxicol 16: 787–797

    Article  PubMed  CAS  Google Scholar 

  70. Collinson PO, Boa FG, Gaze DC (2001) Measurement of cardiac troponins. Ann Clin Biochem 38: 423–449

    PubMed  CAS  Google Scholar 

  71. Wassmuth R, Lentzsch S, Erdbruegger U, Schulz-Menger J, Doerken B, Dietz R, Friedrich MG (2001) Subclinical cardiotoxic effects of anthracyclines as assessed by magnetic resonance imaging-a pilot study. Am Heart J 141: 1007–1013

    Article  PubMed  CAS  Google Scholar 

  72. Ochiai K, Ishibashi Y, Shimada T, Murakami Y, Inoue S, Sano K (1999) Subendocardial enhancement in gadolinium-diethylene-triamine-pentaacetic acid-enhanced magnetic resonance imaging in aortic stenosis. Am J Cardiol 83: 1443–1446

    PubMed  CAS  Google Scholar 

  73. Kitagawa Y, Yamashita D, Ito H, Takaki M (2004) Reversible effects of isoproterenolinduced hypertrophy on in situ left ventricular function in rat hearts. Am J Physiol Heart Circ Physiol 287: H277–H285

    Article  PubMed  CAS  Google Scholar 

  74. Slawson SE, Roman BB, Williams DS, Koretsky AP (1998) Cardiac MRI of the normal and hypertrophied mouse heart. Magn Reson Med 39: 980–987

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. 2800 Plymouth Road 16-1A/6, Ann Arbor, MI, 48105, USA

    Mark W. Tengowski

  2. Pfizer Global Research and Development, Pfizer, Inc., USA

    Mark W. Tengowski & John J. Kotyk

  3. 700 Chesterfield, Parkway West, Saint Louis, MO, 63017, USA

    John J. Kotyk

Authors
  1. Mark W. Tengowski
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. John J. Kotyk
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute for Biomedical Engineering, University of ZĂĽrich/ETH ZĂĽrich, Moussonstr. 18, CH - 8092, ZĂĽrich, Switzerland

    Markus Rudin

  2. Novartis International AG, CH-4002, Basel, Switzerland

    Paul L. Herrling

  3. Novartis Institute for Tropical Diseases, 10 Biopolis Road, #05-01 Chromos, Singapore, 138670, Singapore

    Alex Matter M.D. (Director) (Director)

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Birkhäuser Verlag, Basel (Switzerland)

About this chapter

Cite this chapter

Tengowski, M.W., Kotyk, J.J. (2005). Risk identification and management: MRI as a research tool in toxicology studies of new chemical entities. In: Herrling, P.L., Matter, A., Rudin, M. (eds) Imaging in Drug Discovery and Early Clinical Trials. Progress in Drug Research, vol 62. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7426-8_7

Download citation

Publish with us

Policies and ethics

Search

Navigation