Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Müller WE (2003) Current St. John’s Wort research from mode of action to clinical efficacy. Pharmacol Res 47: 101–109
Gambarana C, Ghiglieri O, Tolu P, De Montis MG, Giachetti D, Bombardelli E, Tagliamonte A (1999) Efficacy of an Hypericum perforatum (St. John’s Wort) extract in preventing and reverting a condition of escape deficit in rats. Neuropsychopharmacol 21: 247–257
Butterweck V, Wall A, Liefländer-Wulf U, Winterhoff H, Nahrstedt A (1997) Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity. Pharmacopsychiatry 30(Suppl): 117–124
Bhattacharya S-K, Chakrabarti A, Chatterjee SS (1998) Activity profiles of two hyperforin-containing Hypericum extracts in behavioral models. Pharmacopsychiatry 31(Suppl 2): 22–29
Cervo L, Rozio M, Ekalle-Soppo CB, Guiso G, Morazzoni P, Caccia S (2002) Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts. Psychopharmacology 164: 423–428
Chatterjee SS, Bhattacharya SK, Wonnemann M, Singer A, Müller WE (1998) Hyperforin as a possible antidepressant component of Hypericum extracts. Life Sci 63: 499–510
Gambarana C, Tolu P, Masi F, Rinaldi M, Giachetti D, Morazzoni P, De Montis MG (2001) A study of the antidepressant activity of Hypericum perforatum on animal models. Pharmacopsychiatry 34(Suppl): 42–44
Usai M, Leggio B, Grappi S, Nanni G, Gambarana C, Tolu P, Giachetti D, De Montis MG (2003) Hypericum perforatum subspecies angustifolium shows a protective activity on the consequences of unavoidable stress exposure at lower doses than Hypericum perforatum perforatum. Pharmacopsychiatry 36: 283–287
Butterweck V, Petereit F, Whinterhoff H, Nahrstedt A (1998) Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test. Planta Med 64: 291–294
Butterweck V, Korte B, Winterhoff H (2001) Pharmacological and endocrine effects of Hypericum perforatum and hypericin after repeated treatment. Pharmacopsychiatry 34(Suppl): 2–7
Erdelmeier CAJ (1998) Hyperforin, possibly the major non-nitrogenous secondary metabolite of Hypericum perforatum L. Pharmacopsychiatry 31(Suppl): 2–6
Nöldner M, Schötz K (2002) Rutin is essential for the antidepressant activity of Hypericum perforatum extracts in the forced swimming test. Planta Med 68: 577–580
Willner P (1990) Animal models of depression: an overview. Pharmacol Ther 45: 425–455
Willner P (1991) Animal models as simulations of depression. Trends Pharmacol Sci 12: 131–136
Willner P (1995) Animal models of depression: validity and applications. Adv Biochem Psychopharmacol 49: 19–41
Dhawan KN, Jaju BP, Gupta GP (1970) Validity of antagonism of different effects of reserpine as test for anti-depressant activity. Psychopharmacologia 18: 94–98
Bourin M (1990) Is it possible to predict the activity of a new antidepressant in animals with simple psychopharmacological tests? Fundam Clin Pharmacol 4: 49–64
Steru L, Chermat R, Thierry B, Simon P (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology 85: 367–370
Steru L, Chermat R, Thierry B, Mico JA, Lenegre A, Steru M, Simon P, Porsolt RD (1987) The automated tail suspension test: a computerized device which differentiates psychotropic drugs. Prog Neuropsychopharmacol Biol Psychiatry 11: 659–671
Porsolt RD, LePichon R, Jalfre R (1977) Depression: a new animal model sensitive to antidepressant treatments. Nature 266: 730–732
Overmier JB, Seligman MEP (1967) Effects of inescapable shock upon subsequent escape and avoidance learning. J Comp Physiol Psychol 63: 23–33
Sherman AD, Sacquitine JL, Petty F (1982) Specificity of the learned helplessness model of depression. Pharmacol Biochem Behav 16: 449–454
Gambarana C, Scheggi S, Tagliamonte A, Tolu P, De Montis MG (2001) Animal models for the study of antidepressant activity. Brain Res Prot 7: 11–20
Meloni D, Gambarana C, De Montis MG, Dal Prà P, Taddei I, Tagliamonte A (1993) Dizocilpine antagonizes the effect of chronic imipramine on learned helplessness in rats, Pharmacol Biochem Behav 46: 423–426
Papp M, Moryl E, Willner P (1996) Pharmacological validation of the chronic mild stress model of depression. Eur J Pharmacol 296: 129–136
Papp M, Willner P, Muscat R (1991) An animal model of anhedonia: attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress. Psychopharmacology 104: 255–259
Ghiglieri O, Gambarana C, Scheggi S, Tagliamonte A, Willner P, De Montis MG (1997) Palatable food induces an appetitive behaviour in satiated rats which can be inhibited by chronic stress. Behav Pharmacol 8: 619–628
Guilhermano LG, Ortiz L, Ferigolo M, Barros HMT (2004) Commercially available Hypericum perforatum extracts do not decrease immobility of rats in the forced swimming test. Prog Neuropsychopharmacol Biol Psychiatry 28: 49–55
Öztürk Y (1997) Testing the antidepressant effects of Hypericum species on animal models. Pharmacopsychiatry 30(Suppl): 125–128
De Vry J, Maurel S, Schreiber R, de Beun R, Jentzsch KR (1999) Comparison of Hypericum extracts with imipramine and fluoxetine in animal models of depression and alcoholism. Eur Neuropsychopharmacol 9: 461–468
Öztürk Y, Aydin S, Beis R, Baser KHC, Berberoglu H (1995) Effects of Hypericum perforatum L. and Hypericum calycinium L. extracts on the central nervous system in mice. Pythomedicine 3: 137–144
Chatterjee SS, Nöldner M, Koch E, Erdelmeier C (1998) Antidepressant activity of Hypericum perforatum and hyperforin: the neglected possibility. Pharmacopsychiatry (Suppl) 31: 7–15
Gambarana C, Grappi S, Nanni G (2001) Dose-dependent antidepressant activity of hyperforin in rats. Soc Neurosci Abstr 27: 975.12
Rezvani AH, Overstreet DH, Yang Y, Clark E Jr, (1999) Attenuation of alcohol intake by extract of Hypericum perforatum (St. John’s Wort) in two different strains of alcohol-preferring rats. Alcohol Alcohol 34: 699–705
Panocka I, Perfumi M, Angeletti S, Ciccocioppo R, Massi M (2000) Effects of Hypericum perforatum extract on ethanol intake, and on behavioral despair: A search for the neurochemical systems involved. Pharmacol Biochem Behav 66: 105–111
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Birkhäuser Verlag/Switzerland
About this chapter
Cite this chapter
Gambarana, C., Giachetti, D. (2005). Efficacy in behavioural models of antidepressant activity. In: Müller, W.E. (eds) St. John’s Wort and its Active Principles in Depression and Anxiety. Milestones in Drug Therapy MDT. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7338-5_6
Download citation
DOI: https://doi.org/10.1007/3-7643-7338-5_6
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-7643-6160-0
Online ISBN: 978-3-7643-7338-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)