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The role of regulatory T cells in cutaneous disorders

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Regulatory T Cells in Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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References

  1. Shevach EM (2002) CD4+ CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol 2: 389–400

    PubMed  Google Scholar 

  2. Baecher-Allan C, Hafler DA (2004) Suppressor T cells in human diseases. J Exp Med 200: 273–276

    PubMed  Google Scholar 

  3. Ou LS, Goleva E, Hall C, Leung DY (2004) T regulatory cells in atopic dermatitis and subversion of their activity by superantigens. J Allergy Clin Immunol 113: 756–763

    PubMed  Google Scholar 

  4. Cavani A, Nasorri F, Ottaviani C, Sebastiani S, De Pita O, Girolomoni G (2003) Human CD25+ regulatory T cells maintain immune tolerance to nickel in healthy, nonallergic individuals. J Immunol 171: 5760–5768

    PubMed  Google Scholar 

  5. Teraki Y, Shiohara T (2003) IFN-gamma-producing effector CD8+ T cells and IL-10-producing regulatory CD4+ T cells in fixed drug eruption. J Allergy Clin Immunol 112: 609–615

    PubMed  Google Scholar 

  6. Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL (2002) CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 420: 502–507

    PubMed  Google Scholar 

  7. Adorini L (2002) Immunomodulatory effects of vitamin D receptor ligands in autoimmune diseases. Int Immunopharmacol 2: 1017–1028

    PubMed  Google Scholar 

  8. Elmets CA, Bergstresser PR, Tigelaar RE, Wood PJ, Streilein JW (1983) Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation. J Exp Med 158: 781–794

    PubMed  Google Scholar 

  9. Steitz J, Bruck J, Lenz J, Knop J, Tuting T (2001) Depletion of CD25(+) CD4(+) T cells and treatment with tyrosinase-related protein 2-transduced dendritic cells enhance the interferon alpha-induced, CD8(+) T-cell-dependent immune defense of B16 melanoma. Cancer Res 61: 8643–8646

    PubMed  Google Scholar 

  10. Taams LS, Vukmanovic-Stejic M, Smith J, Dunne PJ, Fletcher JM, Plunkett FJ, Ebeling SB, Lombardi G, Rustin MH, Bijlsma JW et al (2002) Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells. Eur J Immunol 32: 1621–1630

    PubMed  Google Scholar 

  11. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M (1995) Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155: 1151–1164

    PubMed  Google Scholar 

  12. Jonuleit H, Schmitt E, Stassen M, Tuettenberg A, Knop J, Enk AH (2001) Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med 193: 1285–1294

    PubMed  Google Scholar 

  13. Taams LS, Smith J, Rustin MH, Salmon M, Poulter LW, Akbar AN (2001) Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone population. Eur J Immunol 31: 1122–1131

    PubMed  Google Scholar 

  14. Stephens LA, Mottet C, Mason D, Powrie F (2001) Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur J Immunol 31: 1247–1254

    PubMed  Google Scholar 

  15. Groux H, O’Garra A, Bigler M, Rouleau M, Antonenko S, de Vries JE, Roncarolo MG (1997) A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389: 737–742

    PubMed  Google Scholar 

  16. Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL (1994) Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265: 1237–1240

    PubMed  Google Scholar 

  17. Thornton AM, Shevach EM (1998) CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 188: 287–296

    PubMed  Google Scholar 

  18. Asseman C, Mauze S, Leach MW, Coffman RL, Powrie F (1999) An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 190: 995–1004

    PubMed  Google Scholar 

  19. Nakamura K, Kitani A, Fuss I, Pedersen A, Harada N, Nawata H, Strober W (2004) TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J Immunol 172: 834–842

    PubMed  Google Scholar 

  20. Jutel M, Akdis M, Budak F, Aebischer-Casaulta C, Wrzyszcz M, Blaser K, Akdis CA (2003) IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 33: 1205–1214

    PubMed  Google Scholar 

  21. Colantonio L, Iellem A, Sinigaglia F, D’Ambrosio D (2002) Skin-homing CLA+ T cells and regulatory CD25+ T cells represent major subsets of human peripheral blood memory T cells migrating in response to CCL1/I-309. Eur J Immunol 32: 3506–3514

    PubMed  Google Scholar 

  22. Schaerli P, Ebert L, Willimann K, Blaser A, Roos RS, Loetscher P, Moser B (2004) A Skin-selective homing mechanism for human immune surveillance T cells. J Exp Med 199: 1265–1275

    PubMed  Google Scholar 

  23. Pribila JT, Quale AC, Mueller KL, Shimizu Y (2004) Integrins and T cell-mediated immunity. Annu Rev Immunol 22: 157–180

    PubMed  Google Scholar 

  24. Lehmann J, Huehn J, de la Rosa M, Maszyna F, Kretschmer U, Krenn V, Brunner M, Scheffold A, Hamann A (2002) Expression of the integrin alpha E beta 7 identifies unique subsets of CD25+ as well as CD25− regulatory T cells. Proc Natl Acad Sci USA 99: 13031–13036

    PubMed  Google Scholar 

  25. Stassen M, Fondel S, Bopp T, Richter C, Muller C, Kubach J, Becker C, Knop J, Enk AH, Schmitt S et al (2004) Human CD25+ regulatory T cells: two subsets defined by the integrins alpha4beta7 or alpha4betal confer distinct suppressive properties upon CD4+ T helper cells. Eur J Immunol 34: 1303–1311

    PubMed  Google Scholar 

  26. Patel DD (2001) Escape from tolerance in the human X-linked autoimmunity-allergic disregulation syndrome and the Scurfy mouse. J Clin Invest 107: 155–157

    PubMed  Google Scholar 

  27. Ling EM, Smith T, Nguyen XD, Pridgeon C, Dallman M, Arbery J, Carr VA, Robinson DS (2004) Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet 363: 608–615

    PubMed  Google Scholar 

  28. Cottrez F, Hurst SD, Coffman RL, Groux H (2000) T regulatory cells 1 inhibit a Th2-specific response in vivo. JImmunol 165: 4848–4853

    Google Scholar 

  29. Curotto de Lafaille MA, Muriglan S, Sunshine MJ, Lei Y, Kutchukhidze N, Furtado GC, Wensky AK, Olivares-Villagomez D, Lafaille JJ (2001) Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytes. J Exp Med 194: 1349–1359

    PubMed  Google Scholar 

  30. Bellinghausen I, Klostermann B, Knop J, Saloga J (2003) Human CD4+CD25+ T cells derived from the majority of atopic donors are able to suppress TH1 and TH2 cytokine production. J Allergy Clin Immunol 111: 862–868

    PubMed  Google Scholar 

  31. Furue M, Koga T, Yamashita N (1999) Soluble E-selectin and eosinophil cationic protein are distinct serum markers that differentially represent clinical features of atopic dermatitis. Br J Dermatol 140: 67–72

    PubMed  Google Scholar 

  32. Wakita H, Sakamoto T, Tokura Y, Takigawa M (1994) E-selectin and vascular cell adhesion molecule-1 as critical adhesion molecules for infiltration of T lymphocytes and eosinophils in atopic dermatitis. J Cutan Pathol 21: 33–39

    PubMed  Google Scholar 

  33. Cosmi L, Liotta F, Angeli R, Mazzinghi B, Santarlasci V, Manetti R, Lasagni L, Vanini V, Romagnani P, Maggi E et al (2004) Th2 cells are less susceptible than Thl cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines. Blood 103: 3117–3121

    PubMed  Google Scholar 

  34. Baecher-Allan C, Viglietta V, Hafler DA (2002) Inhibition of human CD4(+) CD25(+high) regulatory T cell function. J Immunol 169: 6210–6217

    PubMed  Google Scholar 

  35. Hori S, Carvalho TL, Demengeot J (2002) CD25+CD4+ regulatory T cells suppress CD4+ T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice. Eur J Immunol 32: 1282–1291

    PubMed  Google Scholar 

  36. Stewart GR, Robertson BD, Young DB (2003) Tuberculosis: a problem with persistence. Nat Rev Microbiol 1: 97–105

    PubMed  Google Scholar 

  37. Schubach A, Haddad F, Oliveira-Neto MP, Degrave W, Pirmez C, Grimaldi G Jr, Fernandes O (1998) Detection of Leishmania DNA by polymerase chain reaction in scars of treated human patients. J Infect Dis 178: 911–914

    PubMed  Google Scholar 

  38. Xu D, Liu H, Komai-Koma M, Campbell C, McSharry C, Alexander J, Liew FY (2003) CD4+CD25+ regulatory T cells suppress differentiation and functions of Thl and Th2 cells, Leishmania major infection, and colitis in mice. J Immunol 170: 394–399

    PubMed  Google Scholar 

  39. Delgado JC, Tsai EY, Thim S, Baena A, Boussiotis VA, Reynes JM, Sath S, Grosjean P, Yunis EJ, Goldfeld AE (2002) Antigen-specific and persistent tuberculin energy in a cohort of pulmonary tuberculosis patients from rural Cambodia. Proc Natl Acad Sci USA 99: 7576–7581

    PubMed  Google Scholar 

  40. Sousa AO, Salem JI, Lee FK, Vercosa MC, Cruaud P, Bloom BR, Lagrange PH, David HL (1997) An epidemic of tuberculosis with a high rate of tuberculin energy among a population previously unexposed to tuberculosis, the Yanomami Indians of the Brazilian Amazon. Proc Natl Acad Sci USA 94: 13227–13232

    PubMed  Google Scholar 

  41. Boussiotis VA, Tsai EY, Yunis EJ, Thim S, Delgado JC, Dascher CC, Berezovskaya A, Rousset D, Reynes JM, Goldfeld AE (2000) IL-10-producing T cells suppress immune responses in anergic tuberculosis patients. J Clin Invest 105: 1317–1325

    PubMed  Google Scholar 

  42. Belkaid Y, Hoffmann KF, Mendez S, Kamhawi S, Udey MC, Wynn TA, Sacks DL (2001) The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. J Exp Med 194: 1497–1506

    PubMed  Google Scholar 

  43. Traidl C, Sebastiani S, Albanesi C, Merk HF, Puddu P, Girolomoni G, Cavani A (2000) Disparate cytotoxic activity of nickel-specific CD8+ and CD4+ T cell subsets against keratinocytes. J Immunol 165: 3058–3064

    PubMed  Google Scholar 

  44. Wang B, Fujisawa H, Zhuang L, Freed I, Howell BG, Shahid S, Shivji GM, Mak TW, Sauder DN (2000) CD4+ Thl and CD8+ type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivity. J Immunol 165: 6783–6790

    PubMed  Google Scholar 

  45. Lecart S, Boulay V, Raison-Peyron N, Bousquet J, Meunier L, Yssel H, Pene J (2001) Phenotypic characterization of human CD4+ regulatory T cells obtained from cutaneous dinitrochlorobenzene-induced delayed type hypersensitivity reactions. J Invest Dermatol 117: 318–325

    PubMed  Google Scholar 

  46. Cavani A, Nasorri F, Prezzi C, Sebastiani S, Albanesi C, Girolomoni G (2000) Human CD4+ T lymphocytes with remarkable regulatory functions on dendritic cells and nickel-specific Thl immune responses. J Invest Dermatol 114: 295–302

    PubMed  Google Scholar 

  47. Friedmann PS, Moss C, Shuster S, Simpson JM (1983) Quantitative relationships between sensitizing dose of DNCB and reactivity in normal subjects. Clin Exp Immunol 53: 709–715

    PubMed  Google Scholar 

  48. Akbar AN, Taams LS, Salmon M, Vukmanovic-Stejic M (2003) The peripheral generation of CD4+ CD25+ regulatory T cells. Immunology 109: 319–325

    PubMed  Google Scholar 

  49. Aiba S, Manome H, Yoshino Y, Tagami H (2000) in vitro treatment of human transforming growth factor-betal-treated monocyte-derived dendritic cells with haptens can induce the phenotypic and functional changes similar to epidermal Langerhans cells in the initiation phase of allergic contact sensitivity reaction. Immunology 101: 68–75

    PubMed  Google Scholar 

  50. Staquet MJ, Sportouch M, Jacquet C, Schmitt D, Guesnet J, Peguet-Navarro J (2004) Moderate skin sensitizers can induce phenotypic changes on in vitro generated dendritic cells. Toxicol In Vitro 18: 493–500

    PubMed  Google Scholar 

  51. Hwang JM, Yamanouchi J, Santamaria P, Kubes P (2004) A critical temporal window for selectin-dependent CD4+ lymphocyte homing and initiation of late-phase inflammation in contact sensitivity. J Exp Med 199: 1223–1234

    PubMed  Google Scholar 

  52. Sebastiani S, Allavena P, Albanesi C, Nasorri F, Bianchi G, Traidl C, Sozzani S, Girolomoni G, Cavani A (2001) Chemokine receptor expression and function in CD4+ T lymphocytes with regulatory activity. J Immunol 166: 996–1002

    PubMed  Google Scholar 

  53. Hoffmann P, Eder R, Kunz-Schughart LA, Andreesen R, Edinger M (2004) Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells. Blood 104: 895–903

    PubMed  Google Scholar 

  54. Kira M, Kobayashi T, Yoshikawa K (2003) Vitamin D and the skin. J Dermatol 30: 429–437

    PubMed  Google Scholar 

  55. Chen X, Murakami T, Oppenheim JJ, Howard OM (2004) Differential response of murine CD4+CD25+ and CD4+. Eur J Immunol 34: 859–869

    PubMed  Google Scholar 

  56. Lebwohl M, Ali S (2001) Treatment of psoriasis. Part 2. Systemic therapies. J Am Acad Dermatol 45: 649–661

    PubMed  Google Scholar 

  57. Gregori S, Casorati M, Amuchastegui S, Smiroldo S, Davalli AM, Adorini L (2001) Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J Immunol 167: 1945–1953

    PubMed  Google Scholar 

  58. Reitamo S, Wollenberg A, Schopf E, Perrot JL, Marks R, Ruzicka T, Christophers E, Kapp A, Lahfa M, Rubins A et al (2000) Safety and efficacy of 1 year of tacrolimus ointment monotherapy in adults with atopic dermatitis. The European Tacrolimus Ointment Study Group. Arch Dermatol 136: 999–1006

    PubMed  Google Scholar 

  59. Toews GB, Bergstresser PR, Streilein JW (1980) Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB. J Immunol 124: 445–453

    PubMed  Google Scholar 

  60. Schwarz A, Maeda A, Wild MK, Kernebeck K, Gross N, Aragane Y, Beissert S, Vestweber D, Schwarz T (2004) Ultraviolet radiation-induced regulatory T cells not only inhibit the induction but can suppress the effector phase of contact hypersensitivity. J Immunol 172: 1036–1043

    PubMed  Google Scholar 

  61. Shreedhar VK, Pride MW, Sun Y, Kripke ML, Strickland FM (1998) Origin and characteristics of ultraviolet-B radiation-induced suppressor T lymphocytes. J Immunol 161: 1327–1335

    PubMed  Google Scholar 

  62. Trenado A, Charlotte F, Fisson S, Yagello M, Klatzmann D, Salomon BL, Cohen JL (2003) Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. J Clin Invest 112: 1688–1696

    PubMed  Google Scholar 

  63. Trenado A, Fisson S, Braunberger E, Klatzmann D, Salomon BL, Cohen JL (2004) Ex vivo selection of recipient-type alloantigen-specific CD4(+)CD25(+) immunoregulatory T cells for the control of graft-versus-host disease after allogeneic hematopoietic stem-cell transplantation. Transplantation 77: S32–S34

    PubMed  Google Scholar 

  64. Graca L, Cobbold SP, Waldmann H (2002) Identification of regulatory T cells in tolerated allografts. J Exp Med 195: 1641–1646

    PubMed  Google Scholar 

  65. Kingsley CI, Karim M, Bushell AR, Wood KJ (2002) CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4-and IL-10-dependent immunoregulation of alloresponses. J Immunol 168: 1080–1086

    PubMed  Google Scholar 

  66. Morris ES, MacDonald KP, Rowe V, Johnson DH, Banovic T, Clouston AD, Hill GR (2004) Donor treatment with pegylated G-CSF augments the generation of IL-10-producing regulatory T cells and promotes transplantation tolerance. Blood 103: 3573–3581

    PubMed  Google Scholar 

  67. Waldmann H, Graca L, Cobbold S, Adams E, Tone M, Tone Y (2004) Regulatory T cells and organ transplantation. Semin Immunol 16: 119–126

    PubMed  Google Scholar 

  68. Krueger JG, Walters IB, Miyazawa M, Gilleaudeau P, Hakimi J, Light S, Sherr A, Gottlieb AB (2000) Successful in vivo blockade of CD25 (high-affinity interleukin 2 receptor) on T cells by administration of humanized anti-Tac antibody to patients with psoriasis. J Am Acad Dermatol 43: 448–458

    PubMed  Google Scholar 

  69. Mrowietz U, Zhu K, Christophers E (2000) Treatment of severe psoriasis with antiCD25 monoclonal antibodies. Arch Dermatol 136: 675–676

    PubMed  Google Scholar 

  70. Wolf AM, Wolf D, Steurer M, Gastl G, Gunsilius E, Grubeck-Loebenstein B (2003) Increase of regulatory T cells in the peripheral blood of cancer patients. Clin Cancer Res 9: 606–612

    PubMed  Google Scholar 

  71. Lens MB, Dawes M (2004) Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma. Br J Dermatol 150: 179–185

    PubMed  Google Scholar 

  72. Onizuka S, Tawara I, Shimizu J, Sakaguchi S, Fujita T, Nakayama E (1999) Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res 59: 3128–3133

    PubMed  Google Scholar 

  73. Steitz J, Bruck J, Lenz J, Knop J, Tuting T (2001) Depletion of CD25(+) CD4(+) T cells and treatment with tyrosinase-related protein 2-transduced dendritic cells enhance the interferon alpha-induced, CD8(+) T-cell-dependent immune defense of B16 melanoma. Cancer Res 61: 8643–8646

    PubMed  Google Scholar 

  74. Sutmuller RP, van Duivenvoorde LM, van Elsas A, Schumacher TN, Wildenberg ME, Allison JP, Toes RE, Offringa R, Melief CJ (2001) Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J Exp Med 194: 823–832

    PubMed  Google Scholar 

  75. O’Garra A, Vieira P (2004) Regulatory T cells and mechanisms of immune system control. Nat Med 10: 801–805

    PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Immunology and Molecular Pathology, Division of Infection and Immunity, University College London, 46, Cleveland Street, London, W1T 4JF, UK

    Katie E. Birch, Milica Vukmanovic-Stejic, John R. Reed & Arne N. Akbarl

  2. Department of Dermatology, Royal Free Hospital, Pond Street, London, NW3 2QG, UK

    Katie E. Birch & Malcolm H.A. Rustin

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  1. Katie E. Birch
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  2. Milica Vukmanovic-Stejic
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  3. John R. Reed
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  4. Malcolm H.A. Rustin
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  5. Arne N. Akbarl
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Editors and Affiliations

  1. Infection & Immunity Research Group, Franklin-Wilkins Building, King’s College London, 150 Stamford Street, London, SE1 9NN, UK

    Leonie S. Taams

  2. Department of Immunohematology and Blood Transfusion, E3-Q, Leiden University Medical Center, Albinusdreef 2, P.O. Box 9600, 2300 RC, Leiden, The Netherlands

    Marca H. M. Wauben

  3. Department of Immunology and Molecular Pathology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London, W1T 4JF, UK

    Arne N. Akbar

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Birch, K.E., Vukmanovic-Stejic, M., Reed, J.R., Rustin, M.H., Akbarl, A.N. (2005). The role of regulatory T cells in cutaneous disorders. In: Taams, L.S., Wauben, M.H.M., Akbar, A.N. (eds) Regulatory T Cells in Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7301-6_11

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