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Simulating Cardiac Mechanoenergetics in the Left Ventricle

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Functional Imaging and Modeling of the Heart (FIMH 2003)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 2674))

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Abstract

Distribution of myocardial perfusion and oxygen consumption within the cardiac wall is spatially heterogeneous. The cause of this heterogeneity is still unclear, but it is expected to be in close relation with the heterogeneity in mechanical function in the heart. In order to study the mechanical contraction and energy consumption by the cardiac wall, we developed a finite element model of the left ventricle with active properties described by the Huxley-type cross-bridge model. Here we present an overview of the developed model and the following simulation results obtained by the model. First, an important property of energy transformation from biochemical form to mechanical work in the cardiac muscle, the linear relationship between the oxygen consumption and the stress-strain area, is replicated by a cross-bridge model. Second, by using the developed cross-bridge model, the correlation between ejection fraction of the left ventricle and heterogeneity of sarcomere strain, developed stress and ATP consumption in the left ventricular wall is established. Third, an experimentally observed linear relationship between oxygen consumption and the pressure-volume area can be predicted theoretically from a linear relationship between the oxygen consumption and the stress-strain area.

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Author information

Authors and Affiliations

  1. Intitute of Cybernetics at Tallinn Technical University, Akadeemia 21, 12618, Tallinn, Estonia

    M. Vendelin & J. Engelbrecht

  2. Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands

    P. H. M. Bovendeerd & T. Arts

  3. Cardiovascular Research Institute, Maastricht University, The Netherlands

    T. Arts

  4. Laboratory of Fundamental and Applied Bioenergetics, INSERM E0221, Joseph Fourier University, Grenoble, France

    V. Saks

Authors
  1. M. Vendelin
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  2. P. H. M. Bovendeerd
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  3. V. Saks
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  4. J. Engelbrecht
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  5. T. Arts
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Editor information

Editors and Affiliations

  1. CREATIS, INSERM, France

    Isabelle E. Magnin

  2. CREATIS, CNRS, INSA, bâatiment Blaise Pascal, 20, avenue Albert Einstein, 69621, Villeurbanne cedex, France

    Johan Montagnat  & Patrick Clarysse  & 

  3. Institute of Biomedical Engineering, Helsinki University of Technology, P.O. Box 2200, 02015, Hut, Finland

    Jukka Nenonen  & Toivo Katila  & 

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© 2003 Springer-Verlag Berlin Heidelberg

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Vendelin, M., Bovendeerd, P.H.M., Saks, V., Engelbrecht, J., Arts, T. (2003). Simulating Cardiac Mechanoenergetics in the Left Ventricle. In: Magnin, I.E., Montagnat, J., Clarysse, P., Nenonen, J., Katila, T. (eds) Functional Imaging and Modeling of the Heart. FIMH 2003. Lecture Notes in Computer Science, vol 2674. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-44883-7_8

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  • DOI: https://doi.org/10.1007/3-540-44883-7_8

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-40262-6

  • Online ISBN: 978-3-540-44883-9

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