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Ornithine carbamoyltransferase

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Springer Handbook of Enzymes

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References

  1. Srivenugopal, K.S.; Adiga, P.R.: Enzymic conversion of agmatine to putrescine in Lathyrus sativus seedlings. Purification and properties of a multifunctional enzyme (putrescine synthase). J. Biol. Chem., 256, 9532–9541 (1981)

    PubMed  CAS  Google Scholar 

  2. Bishop, S.H.; Grisolia, S.: Crystalline ornithine transcarbamylase. Biochim. Biophys. Acta, 139, 344–348 (1967)

    PubMed  CAS  Google Scholar 

  3. Marshall, M.; Cohen, P.P.: Ornithine transcarbamylase from Streptococcus faecalis and bovine liver. I. Isolation and subunit structure. J. Biol. Chem., 247, 1641–1653 (1972)

    PubMed  CAS  Google Scholar 

  4. Marshall, M.; Cohen, P.P.: Ornithine transcarbamylase from Streptococcus faecalis and bovine liver. II. Multiple binding sites for carbamyl-P and l-norvaline, correlation with steady state kinetics. J. Biol. Chem., 247, 1654–1668 (1972)

    PubMed  CAS  Google Scholar 

  5. Marshall, M.; Cohen, P.P.: Ornithine transcarbamylase from Streptococcus faecalis and bovine liver. 3. Effects of chemical modifications of specific residues on ligand binding and enzymatic activity. J. Biol. Chem., 247, 1669–1682 (1972)

    PubMed  CAS  Google Scholar 

  6. Ahmad, S.; Bhatnagar, R.K.; Venkitasubramanian, T.A.: Ornithine transcarbamylase from Mycobacterium smegmatis ATCC 14468: purification, properties, and reaction mechanism. Biochem. Cell Biol., 64, 1349–1355 (1986)

    Article  PubMed  CAS  Google Scholar 

  7. Tsuji, S.; Kanazawa, S.; Fukushina, T.; Oda, S.: Some characteristics of hepatic ornithine transcarbamylase from the house musk shrew, Suncus murinus. Nippon Chikusan Gakkai Ho, 56, 962–970 (1985)

    CAS  Google Scholar 

  8. Glenn, E.; Maretzki, A.: Properties and subcellular distribution of two partially purified ornithine transcarbamoylases in cell suspensions of sugarcane. Plant Physiol., 60, 122–126 (1977)

    PubMed  CAS  Google Scholar 

  9. Boggess, S.F.; Naylor, A.W.: Partial purification and properties of ornithine transcarbamoylase from Nostoc muscorum. Plant Physiol., 56, 640–644 (1975)

    PubMed  CAS  Google Scholar 

  10. Barash, I.; Mor, H.: Control and properties of onithine transcarbamylase in germinated spores of Geotrichum candidum. Plant Cell Physiol., 13, 119–130 (1972)

    CAS  Google Scholar 

  11. Legrain, C; Stalon, V.: Ornithine carbamoyltransferase from Escherichia coli W. Purification, structure and steady-state kinetic analysis. Eur. J. Biochem., 63, 289–301 (1976)

    Article  PubMed  CAS  Google Scholar 

  12. Penninckx, M.; Simon, J.P.; Wiame, J.M.: Interaction between arginase and L-ornithine carbamoyltransferase in Saccharomyces cerevisiae. Purification of S. cerevisiae enzymes and evidence that these enzymes as well as ratliver arginase are trimers. Eur. J. Biochem., 49, 429–442 (1974)

    Article  PubMed  CAS  Google Scholar 

  13. Tam, L.Q.; Patil, S.S.: Mode of action of the toxin from Pseudomonas phaseolicola. II. Mechanism of inhibition of bean ornithine carbamoyltransferase. Plant Physiol., 49, 808–812 (1972)

    PubMed  CAS  Google Scholar 

  14. Laliberte, G.; Hellebust, J.A.: Partial characterization of ornithine carbamoyltransferase in three microalgae. Plant Physiol., 93, 62–66 (1990)

    PubMed  CAS  Google Scholar 

  15. Cohen, N.S.; Cheung, C.W.; Sijuwade, E.; Raijman, L.: Kinetic properties of carbamoyl-phosphate synthase (ammonia) and ornithine carbamoyltransferase in permeabilized mitochondria. Biochem. J., 282, 173–180 (1992)

    PubMed  CAS  Google Scholar 

  16. Siocum, R.D.; Richardson, D.P.: Purification and characterization of ornithine transcarbamoylase from pea (Pisum sativum L.). Plant Physiol., 96, 262–268 (1991)

    Article  Google Scholar 

  17. Jahn, O.; Sauerstein, J.; Reuter, G.: Characterization of two ornithine carbamoyltransferases from Pseudomonas syringae pv. phaseolicola, the producer of phaseolotoxin. Arch. Microbiol., 147, 174–178 (1987)

    Article  PubMed  CAS  Google Scholar 

  18. Roubelakis, K.A.; Kliewer, W.M.: Enzymes of Krebs-Henseleit cycle in Vitis vinifera L.. Plant Physiol., 62, 337–339 (1978)

    PubMed  CAS  Google Scholar 

  19. De Ruiter, H.; Kollöffel, C: Properties of ornithine carbamoyltransferase from Pisumsativum L.. Plant Physiol., 77, 695–699 (1985)

    PubMed  Google Scholar 

  20. Szilagyi, I.; Vargha, G.; Szabo, G.: Ornithine carbamoyltransferase of Streptomyces fradiae: purification and properties. FEMS Microbiol. Lett., 48, 115–119 (1987)

    Article  CAS  Google Scholar 

  21. Kurtin, W.E.; Bishop, S.H.; Himoe, A.: Ornithine transcarbamylase: steady-state kinetic properties. Biochem. Biophys. Res. Commun., 45, 551–556 (1971)

    Article  PubMed  CAS  Google Scholar 

  22. Mori, M.; Aoyagi, K.; Tatibana, M.; Ishikawa, T.; Ishii, H.: N ±-(phosphonacetyl)-l-ornithine, a potent transition state analogue inhibitor of ornithine carbamoyltransferase. Biochem. Biophys. Res. Commun., 76, 900–904 (1977)

    Article  PubMed  CAS  Google Scholar 

  23. Eid, S.; Waly, Y.; Abdelal, A.T.: Separation and properties of two ornithine carbamoyltransferases from Pisum sativum seedlings. Phytochemistry, 13, 99–102 (1974)

    Article  CAS  Google Scholar 

  24. Abdelal, A.T.H.; Kennedy, E.H.; Nainan, O.: Ornithine transcarbamylase from Salmonella typhimurium: purification, subunit composition, kinetic analysis, and immunological cross-reactivity. J. Bacteriol., 129, 1387–1396 (1977)

    PubMed  CAS  Google Scholar 

  25. Hoogenraad, N.J.; Sutherland, T.M.; Howlett, G.J.: Purification of ornithine transcarbamylase from rat liver by affinity chromatography with immobilized transition-state analog. Anal. Biochem., 101, 97–102 (1980)

    Article  PubMed  CAS  Google Scholar 

  26. Martin, E; Hirel, B.; Gadal, P.: Purification and properties of ornithine carbamoyltransferase 1 from Alnus glutinosa root nodules. Z. Pflanzenphysiol., 111, 413–422 (1983)

    CAS  Google Scholar 

  27. Hoogenraad, N.J.: Synthesis and properties of δ-N-(phosphonacetyl)-l-ornithine. A transitionstate analog inhibitor of ornithine transcarbamylase. Arch. Biochem. Biophys., 188, 137–144 (1978)

    Article  PubMed  CAS  Google Scholar 

  28. Powers, C.N.; Pierson, D.L.: Stabilization and purification of ornithine transcarbamylase from Neisseria gonorrhoeae. J. Bacteriol., 141, 544–549 (1980)

    PubMed  CAS  Google Scholar 

  29. Baker, S.R.; Yon, R.J.: Characterization of ornithine carbamoyltransferase from cultured carrot cells of low embryogenic potential. Phytochemistry, 22, 2171–2174 (1983)

    Article  CAS  Google Scholar 

  30. Miller, N.T.; Feibush, B.; Corina, K.; Powers-Lee, S.; Karger, B.L.: High-performance hydrophobic interaction chromatography: purification of rat liver carbamoylphosphate synthetase I and ornithine transcarbamoylase. Anal. Biochem., 148, 510–517 (1985)

    Article  PubMed  CAS  Google Scholar 

  31. Bates, M.; Weiss, R.L.; Clarke, S.: Ornithine transcarbamylase from Neurospora crassa: purification and properties. Arch. Biochem. Biophys., 239, 172–183 (1985)

    Article  PubMed  CAS  Google Scholar 

  32. Tsuji, S.: Chicken ornithine transcarbamylase: purification and some properties. J. Biochem., 94, 1307–1315 (1983)

    PubMed  CAS  Google Scholar 

  33. Templeton, M.D.; Sullivan, P.A.; Sheperd, M.G.: The inhibition of ornithine transcarbamoylase from Escherichia coli W by phaseolotoxin. Biochem. J., 224, 379–388 (1984)

    PubMed  CAS  Google Scholar 

  34. Neway, J.O.; Switzer, R.L.: Purification, characterization, and physiological function of Bacillus subtilis ornithine transcarbamylase. J. Bacteriol., 155, 512–521 (1983)

    PubMed  CAS  Google Scholar 

  35. Xiong, X.; Anderson, P.M.: Purification and properties of ornithine carbamoyl transferase from liver of Squalus acanthias. Arch. Biochem. Biophys., 270, 198–207 (1989)

    Article  PubMed  CAS  Google Scholar 

  36. Lusty, C.J.; Jilka, R.L.; Nietsch, E.H.: Ornithine transcarbamylase of rat liver. Kinetic, physical, and chemical properties. J. Biol. Chem., 254, 10030–10036 (1979)

    PubMed  CAS  Google Scholar 

  37. Marshall, M.; Cohen, P.P.: The essential sulfhydryl group of ornithine transcarbamylases. Reaction with anionic, aromatic disulfides and properties of its cyano derivative. J. Biol. Chem., 255, 7291–7295 (1980)

    PubMed  CAS  Google Scholar 

  38. Eisenstein, E.; Osborn, J.C.; Chaiken, I.M.; Hensley, P.: Purification and characterization of ornithine transcarbamoylase from Saccharomyces cerevisiae. J. Biol. Chem., 259, 5139–5145 (1984)

    PubMed  CAS  Google Scholar 

  39. Pierson, D.L.; Cox, S.L.; Gilbert, B.E.: Human ornithine transcarbamylase. Purification and characterization of the enzyme from normal liver and the liver of a Reyes syndrome patient. J. Biol. Chem., 252, 6464–6469 (1977)

    PubMed  CAS  Google Scholar 

  40. Kalousek, E; Francois, B.; Rosenberg, L.E.: Isolation and characterization of ornithine transcarbamylase from normal human liver. J. Biol. Chem., 253, 3939–3944 (1978)

    PubMed  CAS  Google Scholar 

  41. Koger, J.B.; Howell, R.G.; Kelly, M.; Jones, E.E.: Purification and properties of porcine liver ornithine transcarbamylase. Arch. Biochem. Biophys., 309, 293–299 (1994)

    Article  PubMed  CAS  Google Scholar 

  42. Tricot, C; Schmid, S.; Baur, H.; Villeret, V.; Dideberg, O.; Haas, D.; Stalon, V.: Catabolic ornithine carbamoyltransferase of Pseudomonas aeruginosa. Changes of allosteric properties resulting from modifications at the C-terminus. Eur. J. Biochem., 221, 555–561 (1994)

    Article  PubMed  CAS  Google Scholar 

  43. Ruepp, A.; Mueller, H.N.; Lottspeich, R; Soppa, J.: Catabolic ornithine transcarbamylase of Halobacterium halobium (salinarium): purification, characterization, sequence determination, and evolution. J. Bacteriol., 177, 1129–1136 (1995)

    PubMed  CAS  Google Scholar 

  44. Coque, J.J.R.; Perez-Llarena, F.J.; Enguita, F.J.; Fuente, J.L.; Martin, J.F.; Liras, P.: Characterization of the cmcH genes of Nocardia lactamdurans and Streptomyces clavuligerus encoding a functional 3’-hydroxymethylcephem O-carbamoyltransferase for cephamycin biosynthesis. Gene, 162, 21–27 (1995)

    Article  PubMed  CAS  Google Scholar 

  45. Legrain, C; Villeret, V.; Roovers, M.; Gigot, D.; Dideberg, O.; Pierard, A.; Glansdorff, N.: Biochemical characterization of ornithine carbamoyltransferase from Pyrococcus furiosus. Eur. J. Biochem., 247, 1046–1055 (1997)

    Article  PubMed  CAS  Google Scholar 

  46. Morizono, H.; Tuchman, M.; Rajagopal, B.S.; McCann, M.T.; Listrom, CD.; Yuan, X.; Venugopal, D.; Barany, G.; Allewell, N.M.: Expression, purification and kinetic characterization of wild-type human ornithine transcarbamylase and a recurrent mutant that produces ‘late onset’ hyperammonemia. Biochem. J., 322, 625–631 (1997)

    PubMed  CAS  Google Scholar 

  47. Sanchez, R.; Baetens, M.; Van De Casteele, M.; Roovers, M.; Legrain, C; Glansdorff, N.: Ornithine carbamoyltransferase from the extreme thermophile Thermus thermophilus. Analysis of the gene and characterization of the protein. Eur. J. Biochem., 248, 466–474 (1997)

    Article  PubMed  CAS  Google Scholar 

  48. Lee, Y.; Jun, B.O.; Kim, S.G.; Kwon, Y.M.: Purification of ornithine carbamyltransferase from kidney bean (Phaseolus vulgaris) leaves and comparison of the properties of the enzyme from canavaninecontaining and-deficient plants. Planta, 205, 375–379 (1998)

    Article  PubMed  CAS  Google Scholar 

  49. Villeret, V; Clantin, B.; Tricot, C; Legrain, C; Roovers, M.; Stalon, V; Glansdorff, N.; Van Beeumen, J.: The crystal structure of Pyrococcus furiosus ornithine carbamoyltransferase reveals a key role for oligomerization in enzyme stability at extremely high temperatures. Proc. Natl. Acad. Sci. USA, 95, 2801–2806 (1998)

    Article  PubMed  CAS  Google Scholar 

  50. Tricot, C; Villeret, V; Sainz, G.; Dideberg, O.; Stalon, V: Allosteric regulation in Pseudomonas aeruginosa catabolic ornithine carbamoyltransferase revisited: association of concerted homotropic cooperative interactions and local heterotropic effects. J. Mol. Biol., 283, 695–704 (1998)

    Article  PubMed  CAS  Google Scholar 

  51. Sainz, G.; Tricot, C; Foray, M.F.; Marion, D.; Dideberg, O.; Stalon, V: Kinetic studies of allosteric catabolic ornithine carbamoyltransferase from Pseudomonas aeruginosa. Eur. J. Biochem., 251, 528–533 (1998)

    Article  PubMed  CAS  Google Scholar 

  52. Sainz, G.; Vicat, J.; Kahn, R.; Tricot, C; Stalon, V; Dideberg, O.: Purification, crystallization and preliminary X-ray analysis of catabolic ornithine carbamoyltransferase from Pseudomonas aeruginosa. Acta Crystallogr. Sect. D, 55, 1591–1593 (1999)

    Article  CAS  Google Scholar 

  53. Langley, D.B.; Templeton, M.D.; Fields, B.A.; Mitchell, R.E.; Collyer, C.A.: Mechanism of inactivation of ornithine transcarbamoylase by Nδ-(N’-sulfo-diaminophosphinyl)-l-ornithine, a true transition state analogue? Crystal structure and implications for catalytic mechanism. J. Biol. Chem., 275, 20012–20019 (2000)

    Article  PubMed  CAS  Google Scholar 

  54. Lee, Y.; Kwon, Y.M.: Identification of an isoform of ornithine carbamoyltransferase that can effectively utilize canaline as a substrate from the leaves of Canavalia lineata. Plant Sci., 151, 145–151 (2000)

    Article  PubMed  CAS  Google Scholar 

  55. Shi, D.; Morizono, H.; Yu, X.; Tong, L.; Allewell, N.M.; Tuchman, M.: Human ornithine transcarbamylase: crystallographic insights into substrate recognition and conformational changes. Biochem. J., 354, 501–509 (2001)

    Article  PubMed  CAS  Google Scholar 

  56. Roovers, M.; Sanchez, R.; Legrain, C; Glansdorff, N.: Experimental evolution of enzyme temperature activity profile: selection in vivo and characterization of low-temperature-adapted mutants of Pyrococcus furiosus ornithine carbamoyltransferase. J. Bacteriol., 183, 1101–1105 (2001)

    Article  PubMed  CAS  Google Scholar 

  57. Lee, Y; Choi, Y.A.; Hwang, I.D.; Kim, S.G.; Kwon, Y.M.: cDNA cloning of two isoforms of ornithine carbamoyltransferase from Canavalia lineata leaves and the effect of site-directed mutagenesis of the carbamoyl phosphate binding site. Plant Mol. Biol., 46, 651–660 (2001)

    Article  PubMed  CAS  Google Scholar 

  58. Bellocco, E.; Di Salvo, C; Lagana, G.; Leuzzi, U.; Tellone, E.; Kotyk, A.; Galtieri, A.: Purification and properties of ornithine carbamoyltransferase from loggerhead turtle liver. Physiol. Res., 51, 151–158 (2002)

    PubMed  CAS  Google Scholar 

  59. Bellocco, E.; Di Salvo, C; Lagana, G.; Garden, A.; Ficarra, S.; Kotyk, A.; Leuzzi, U.: Ornithine carbamoyltransferase from Spinacia oleracea: purification and characterization. Biol. Plant., 45, 533–538 (2002)

    Article  CAS  Google Scholar 

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(2006). Ornithine carbamoyltransferase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Springer Handbook of Enzymes. Springer Handbook of Enzymes, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-37716-6_14

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