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NADPH-Ferrihemoprotein reductase

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Springer Handbook of Enzymes

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References

  1. Kojima, H.; Takahashi, K.; Sakane, F.; Koyama, J.: Purification and characterization of NADPH-cytochrome c reductase from porcine polymorphonuclear leukocytes. J. Biochem., 102, 1083–1088 (1987)

    PubMed  CAS  Google Scholar 

  2. Kurzban, G.P.; Howarth, J.; Palmer, G.; Strobel, H.W.: NADPH-cytochrome P-450 reductase. Physical properties and redox behavior in the absence of the FAD moiety. J. Biol. Chem., 265, 12272–12279 (1990)

    PubMed  CAS  Google Scholar 

  3. Laporte, F.; Doussiere, J.; Vignais, P.V.: Properties of the NADPH dehydrogenase component of the oxidase complex from rabbit peritoneal neutrophils: reconstitution of an oxidase activity with the dehydrogenase component and a membrane extract. Biochem. Biophys. Res. Commun., 167, 790–797 (1990)

    Article  PubMed  CAS  Google Scholar 

  4. Laporte, F.; Doussiere, J.; Vignais, P.V.: Characterization of multiple active forms of the NADPH dehydrogenase component of the oxidase complex from rabbit peritoneal neutrophils by photolabeling with an arylazido derivative of NADP+. Biochem. Biophys. Res. Commun., 168, 78–84 (1990)

    CAS  Google Scholar 

  5. Vibet, A.; Dintinger, T.; Maboundou, J.C.; Gaillard, J.L.; Divoux, D.; Silberzahn, P.: Estrogen synthetase in the horse. Comparison of equine placental and rat liver NADPH-cytrochrome c (P-450) reductase activities. FEBS Lett., 261, 31–34 (1990)

    Article  PubMed  CAS  Google Scholar 

  6. Benveniste, I.; Lesot, A.; Hasenfratz, M.; Durst, F.: Immunochemical characterization of NADPH-cytochrome P-450 reductase from Jerusalem artichoke and other higher plants. Biochem. J., 259, 847–853 (1989)

    PubMed  CAS  Google Scholar 

  7. Kurokawa, T.; Fukumori, Y.; Yamanaka, T.: Purification of a flavoprotein having NADPH-cytochrome c reductase and transhydrogenase activities from Nitrobacter winogradskyi and its molecular and enzymatic properties. Arch. Microbiol., 148, 95–99 (1987)

    Article  CAS  Google Scholar 

  8. Ardies, C.M.; Lasker, J.M.; Bloswick, B.P.; Lieber, C. S.: Purification of NADPH:cytochrome c (cytochrome P-450) reductase from hamster liver microsomes by detergent extraction and affinity chromatography. Anal. Biochem., 162, 39–46 (1987)

    Article  PubMed  CAS  Google Scholar 

  9. Benveniste, I.; Gabriac, B.; Durst, F.: Purification and characterization of the NADPH-cytochrome P-450 (cytochrome c) reductase from higher-plant microsomal fraction. Biochem. J., 235, 365–373 (1986)

    PubMed  CAS  Google Scholar 

  10. Takahashi, N.; Saito, T.; Goda, Y.; Tomita, K.: Characterization of microsomal NADPH-dependent aldehyde reductase from rat brain. J. Biochem., 99, 513–519 (1986)

    PubMed  CAS  Google Scholar 

  11. Kuwada, M.; Ohsawa, Y.; Horie, S.: Purification of NADPH-cytochrome c reductase from swine testis microsomes by chromatofocusing and characterization of the purified reductase. Biochim. Biophys. Acta, 830, 45–51 (1985)

    PubMed  CAS  Google Scholar 

  12. Kuwahara, T.; White, R.A.; Agosin, M.: A cytosolic FAD-containing enzyme catalyzing cytochrome c reduction in Trypanosoma cruzi. I. Purification and some properties. Arch. Biochem. Biophys., 239, 18–28 (1985)

    Article  PubMed  CAS  Google Scholar 

  13. Laurila, H.; Käppeli, O.; Fiechter, A.: The cytochrome P450-containing monooxygenase of Trichosporon cutaneum: occurrence and properties. Arch. Microbiol., 140, 257–259 (1984)

    Article  PubMed  CAS  Google Scholar 

  14. Sakane, F.; Takahashi, K.; Koyama, J.: Purification and characterization of a membrane-bound NADPH-cytochrome c reductase capable of catalyzing menadione-dependent O- 2 formation in guinea pig polymorphonuclear leukocytes. J. Biochem., 96, 671–678 (1984)

    PubMed  CAS  Google Scholar 

  15. Sierralta, W.D.; Szendro, P.I.: Characterization of microsomal subfractions from porcine endometrium cells. Hoppe-Seyler’s Z. Physiol. Chem., 364, 1329–1335 (1983)

    PubMed  CAS  Google Scholar 

  16. Shephard, E.A.; Pike, S.F.; Rabin, B.R.; Phillips, I. R.: A rapid one-step purification of NADPH-cytochrome c (P-450) reductase from rat liver microsomes. Anal. Biochem., 129, 430–433 (1983)

    Article  PubMed  CAS  Google Scholar 

  17. Honeck, H.; Schunck, W.H.; Riege, P.; Muller, H.G.: The cytochrome P-450 alkane monooxygenase system of the yeast Lodderomyces elongisporus: purification and some properties of the NADPH-cytochrome P-450 reductase. Biochem. Biophys. Res. Commun., 106, 1318–1324 (1982)

    Article  PubMed  CAS  Google Scholar 

  18. Jayanthi, C.R.; Madyastha, P.; Madyastha, K.M.: Microsomal 11α-hydroxylation of progesterone in Aspergillus ochraceus: Part I: Characterization of the hydroxylase system. Biochem. Biophys. Res. Commun., 106, 1262–1268 (1982)

    Article  PubMed  CAS  Google Scholar 

  19. Kamimura, K.; Tsuchiya, E.; Miyakawa, T.; Fuki, S.; Hirata, A.: Isolation and characterization of the nuclei from Saccharomyces cerevisiae. Curr. Microbiol., 6, 175–180 (1981)

    Article  CAS  Google Scholar 

  20. Bertrand, J.C.; Gilewicz, M.; Bazin, H.; Azoulay, E.: Purified detergent-solubilized NADPH-cytochrome c (P-450) reductase from Candida tropicalis grown on alkanes. Biochem. Biophys. Res. Commun., 94, 889–893 (1980)

    Article  PubMed  CAS  Google Scholar 

  21. Crankshaw, D.L.; Hetnarski, K.; Wilkinson, C.F.: Purification and characterization of NADPH-cytochrome c reductase from the midgut of the southern armyworm (Spodoptera eridania). Biochem. J., 181, 593–605 (1979)

    PubMed  CAS  Google Scholar 

  22. Bertrand, J.C.; Gilewicz, M.; Bazin, H.; Zacek, M.; Azoulay, E.: Partial purification of cytochrome P-450 of Candida tropicalis and reconstitution of hydroxylase activity. FEBS Lett., 105, 143–146 (1979)

    Article  PubMed  CAS  Google Scholar 

  23. Tryon, E.; Cress, M.C.; Hamada, M.; Kuby, S.A.: Studies on NADPH-cytochrome c reductase I: Isolation and several properties of the crystalline enzyme from ale yeast. Arch. Biochem. Biophys., 197, 104–118 (1979)

    Article  PubMed  CAS  Google Scholar 

  24. Madyastha, K.M.; Coscia, C.J.: Detergent-solubilized NADPH-cytochrome c(P-450) reductase from the higher plant, Catharanthus roseus. Purification and characterization. J. Biol. Chem., 254, 2419–2427 (1979)

    PubMed  CAS  Google Scholar 

  25. Kulkoski, J.A.; Weber, J.L.; Ghazarian, J.G.: NADPH-cytochrome c reductase in outer membrane of kidney mitochondria. Purification and properties. Arch. Biochem. Biophys., 192, 539–547 (1979)

    Article  PubMed  CAS  Google Scholar 

  26. Bertrand, J.C.; Bazin, H.; Zacek, M.; Gilewicz, M.; Azoulay, E.: NADPH-cytochrome c reductase of Candida tropicalis grown on alkane. Eur. J. Biochem., 93, 237–243 (1979)

    Article  PubMed  CAS  Google Scholar 

  27. Zimmermann, J.J.; Kasper, C.B.: Immunological and biochemical characterization of nuclear envelope reduced nicotinamide adenine dinucleotide phosphate-cytochrome c oxidoreductase. Arch. Biochem. Biophys., 190, 726–735 (1978)

    Article  Google Scholar 

  28. Kubota, S.; Yoshida, Y.; Kumaoka, H.; Furumichi, A.: Studies on the microsomal electron-transport system of anaerobically grown yeast. V. Purification and characterization of NADPH-cytochrome c reductase. J. Biochem., 81, 197–205 (1977)

    PubMed  CAS  Google Scholar 

  29. Yasukochi, Y.; Masters, B.S.S.: Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography. J. Biol. Chem., 251, 5337–5344 (1976)

    PubMed  CAS  Google Scholar 

  30. Arinc, E.; Philpot, R.M.: Preparation and properties of partially purified pulmonary cytochrome P-450 from rabbits. J. Biol. Chem., 251, 3213–3220 (1976)

    PubMed  CAS  Google Scholar 

  31. Masters, B.S.S.; Prough, R.A.; Kamin, H.: Properties of the stable aerobic and anaerobic half-reduced states of NADPH-cytochrome c reductase. Biochemistry, 14, 607–613 (1975)

    Article  CAS  Google Scholar 

  32. Fan, L.L.; Masters, B.S.S.: Properties of purified kidney microsomal NADPH-cytochrome c reductase. Arch. Biochem. Biophys., 165, 665–671 (1974)

    Article  PubMed  CAS  Google Scholar 

  33. Teschke, R.; Hasumura, Y.; Lieber, C.S.: Hepatic microsomal ethanol-oxidizing system: solubilization, isolation, and characterization. Arch. Biochem. Biophys., 163, 404–415 (1974)

    Article  PubMed  CAS  Google Scholar 

  34. Betz, G.; Roper, M.; Tsai, P.: Steroid 17,20-lyase from testis microsomes: participation of NADPH cytochrome c reductase. Arch. Biochem. Biophys., 163, 318–323 (1974)

    Article  PubMed  CAS  Google Scholar 

  35. Iyanagi, T.: Some properties of kidney cortex and splenic microsomal NADPH-cytochrome c reductase. FEBS Lett., 46, 51–54 (1974)

    Article  PubMed  CAS  Google Scholar 

  36. Golf, S.W.; Graef, V.; Staudinger, H.: Solubilization and purification of the NADPH-cytochrome reductase from rat liver microsomes. Hoppe-Seyler’s Z. Physiol. Chem., 355, 1063–1069 (1974)

    CAS  Google Scholar 

  37. Yoshida, Y.; Kumaoka, H.; Sato, R.: Studies on the microsomal electrontransport system of anaerobically grown yeast. I. Intracellular localization and characterization. J. Biochem., 75, 1201–1210 (1974)

    PubMed  CAS  Google Scholar 

  38. Ichihara, K.; Kusunose, E.; Kusunose, M.: Some properties of NADPH-cytochrome c reductase reconstitutively active in fatty-acid ω-hydroxylation. Eur. J. Biochem., 38, 463–472 (1973)

    Article  PubMed  CAS  Google Scholar 

  39. Iyanagi, T.; Mason, H.S.: Some properties of hepatic reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase. Biochemistry, 12, 2297–2308 (1973)

    Article  PubMed  CAS  Google Scholar 

  40. Poole, R.K.; Nicholl, W.G.; Howells, L.; Lloyd, D.: The microsomal fraction from Tetrahymena pyriformis strain ST: characterization and subfractionation. J. Gen. Microbiol., 68, 283–294 (1971)

    PubMed  CAS  Google Scholar 

  41. Omura, T.; Takesue, S.: A new method for simultaneous purification of cytochrome b5 and NADPH-cytochrome c reductase from rat liver microsomes. J. Biochem., 67, 249–257 (1970)

    PubMed  CAS  Google Scholar 

  42. Aoyama, Y.; Yoshida, Y.; Kubota, S.; Kamaoka, H.; Furumichi, A.: NADPH-cytochrome P-450 reductase of yeast microsomes. Arch. Biochem. Biophys., 185, 362–369 (1978)

    Article  PubMed  CAS  Google Scholar 

  43. Cooper, M.B.; Craft, J.A.; Estall, M.R.; Rabin, B.R.: Asymmetric distribution of cytochrome P-450 and NADPH-cytochrome P-450 (cytochrome c) reductase in vesicles from smooth endoplasmic reticulum of rat liver. Biochem. J., 190, 737–746 (1980)

    PubMed  CAS  Google Scholar 

  44. Mayer, R.T.; Durrant, J.L.: Purified NADPH cytochrome P-450 reductase. Interaction with hepatic microsomes and phospholipid vesicles. J. Biol. Chem., 254, 4177–4185 (1979)

    Google Scholar 

  45. Osawa, Y.; Higashiyama, T.; Nakamura, T.: Species specificity of estrogen biosynthesis in pregnancy. Immunochemical difference of placental NADPH-cytochrome c (P-450) reductase in human, baboon and horse. J. Steroid Biochem., 15, 449–452 (1981)

    Article  PubMed  CAS  Google Scholar 

  46. Yasukochi, Y.; Masters, B.S.S.: Tetramer-dimer dissociation in homoglobin and the Bohr effect. J. Biol. Chem., 251, 5537–5544 (1976)

    Google Scholar 

  47. Masters, B.S.S.; Williams, C.H.; Kamin, H.: Preparation and properties of microsomal TPNH-cytochrome c reductase from pig liver. Methods Enzymol., 10, 565–573 (1967)

    Article  CAS  Google Scholar 

  48. Maisterrena, B.; Comte, J.; Gautheron, D.C.: Purification of pig heart mitochondrial membranes, enzymatic and morphological characterization as compared to microsomes. Biochim. Biophys. Acta, 367, 115–126 (1974)

    Article  PubMed  CAS  Google Scholar 

  49. Mull, R.H.; Voigt, T.; Flemming, K.: Characterization of microsomal electron transport components from control, phenobarbital, and 3-methylcholantrene treated mice: I. Distribution of electron transport components in ammonium sulfate fractions from mouse liver microsomes. Biochem. Biophys. Res. Commun., 64, 1098–1106 (1975)

    Article  PubMed  CAS  Google Scholar 

  50. Day, D.A.; Wiskich, J.T.: Isolation and properties of the outer membrane of plant mitochondria. Arch. Biochem. Biophys., 171, 117–123 (1975)

    Article  PubMed  CAS  Google Scholar 

  51. Erecinska, M.: Cytochrome c interaction with membranes, formylated cytochrome cl. Arch. Biochem. Biophys., 169, 199–208 (1975)

    Article  PubMed  CAS  Google Scholar 

  52. Bowles, D.J.; Kauss, H.: Characterization, enzymatic and lectin properties of isolated membranes from Phaseolus aureus. Biochim. Biophys. Acta, 443, 360–374 (1976)

    Article  PubMed  CAS  Google Scholar 

  53. Gilkes, N.R.; Weeks, G.: The purification and characterization of Dictyostelium discoideum plasma membranes. Biochim. Biophys. Acta, 464, 142–156 (1977)

    Article  PubMed  CAS  Google Scholar 

  54. Gilkes, N.R. and Weeks, G.: An improved procedure for the purification of plasma membranes from Dictyostelium discoideum. Can. J. Biochem., 55, 1233–1236 (1977)

    Article  PubMed  CAS  Google Scholar 

  55. Mull, R.H.; Schgaguler, M.. Mönig, H.; Voigt, T.; Flemming, K.: Characterization of microsomal electron transport components from control, phenobarbital-and 3-methylcholantrene-treated mice, III. Improved resolution and quantitation of major components in ammonium sulfate fractions from total liver microsomes. Biochim. Biophys. Acta, 462, 671–688 (1977)

    Article  PubMed  CAS  Google Scholar 

  56. Yoshida, Y.; Aoyama, Y.; Kumaoka, H.; Kubota, S.: A highly purified preparation of cytochrome P-450 from microsomes of anaerobically grown yeast. Biochem. Biophys. Res. Commun., 78, 1005–1010 (1977)

    Article  PubMed  CAS  Google Scholar 

  57. Feyereisen, R.; Durst, F.: Ecdysterone Biosynthesis: A microsomal cytochrome-P-450-linked ecdysone 20-monooxygenase from tissues of the african migratory locust. Eur. J. Biochem., 88, 37–47 (1978)

    Article  PubMed  CAS  Google Scholar 

  58. Dialameh, G.H.: Isolation and partial purification of cytochrome-P-450 from induced rat liver. Biochem. Biophys. Res. Commun., 81, 19–23 (1978)

    Article  PubMed  CAS  Google Scholar 

  59. Yoshida, T.; Kikuchi, G.: Purification and properties of heme oxygenase from rat liver microsomes. J. Biol. Chem., 254, 4487–4491 (1979)

    PubMed  CAS  Google Scholar 

  60. Kitada, M.; Yamazaki, C.; Hirota, K.; Kitagawa, H.: Purification of cytochrome P-450 from liver microsomes of phenobarbital-treated guinea pigs. Biochem. Biophys. Res. Commun., 93, 1020–1026 (1980)

    Article  PubMed  CAS  Google Scholar 

  61. Hara, T.; Taniguchi, M.: Relationship between changes in properties and contents of riboflavin derivatives of NADPH-cytochrome P-450 reductase in the liver microsomes of riboflavin-deficient rats. J. Biochem., 97, 473–482 (1985)

    Google Scholar 

  62. Gut, J.; Kawato, S.; Cherry, R.J.; Winterhalter, K.H.; Richter, C.: Lipid peroxidation decreases the rotational mobility of cytochrome P-450 in rat liver microsomes. Biochim. Biophys. Acta, 817, 217–228 (1985)

    Article  PubMed  CAS  Google Scholar 

  63. Lindeskog, P.; Haaparanta, T.; Norgard, M.; Glaumann, H.; Hansson, T.; Gustafsson J.: Isolation of rat intestinal microsomes: Partial characterisation of mucosal cytochrome P-450. Arch. Biochem. Biophys., 244, 492–501 (1986)

    Article  PubMed  CAS  Google Scholar 

  64. Kutty, R.K.; Maines, M.D.: Characterization of an NADH-dependent haemdegrading system in ox heart mitochondria. Biochem. J., 246, 467–474 (1987)

    PubMed  CAS  Google Scholar 

  65. Dupuy, C.; Kaniewski, J.; Deme, D.; Pommier, J.; Virion, A.: NADPH-dependent H2O2 generation catalyzed by thyroid plasma membranes. Eur. J. Biochem., 185, 597–603 (1989)

    Article  PubMed  CAS  Google Scholar 

  66. Shoun, H.; Sudo, Y.; Sato, K.; Beppu, T.: Components of the cytochrome P-450 monooxygenase system of the fungus, Fusarium oxysporun: Conditions for induction and isolation of cytochrome b5. Agric. Biol. Chem., 53, 2153–2161 (1989)

    CAS  Google Scholar 

  67. Arinc, E.; Sen, A.: Characterization of cytochrome P450 dependent mixedfuction oxidase system of gilthead seabream (Sparus aurata; sparidae) liver. Comp. Biochem. Physiol. B, 104, 133–139 (1993)

    Article  Google Scholar 

  68. Balvers, W.G.; Boersma, M.G.; Vervoort, J.; Ouwehand, A.; Rietjens, I.M.C.M.: A specific interaction between NADPH-cytochrome reductase and phosphatidylserine and phosphatidylinositol. Eur. J. Biochem., 218, 1021–1029 (1993)

    Article  PubMed  CAS  Google Scholar 

  69. White, R.D.; Hahn, M.E.; Lockhart, W.L.; Stegeman, J.J.: Catalytic and Immunochemical Characterization of Hepatic Microsomal cytochromes P450 in Beluga Whale (Delphinapterus leucas). Toxicol. Appl. Pharmacol., 126, 45–57 (1994)

    Article  PubMed  CAS  Google Scholar 

  70. Lee, C.A.; Kadwell, S.H.; Kost, T.A.; Serabjit-Singh, C.J.: CYP3A4 expressed by insect cells infected with a recombinant baculovirus containing both CYP3A4 and human NADPH-cytochrome P450 reductase is catalytically similar to human liver microsomal CYP3A4. Arch. Biochem. Biophys., 319, 157–167 (1995)

    Article  PubMed  CAS  Google Scholar 

  71. Murataliev, M.B.; Feyereisen, R.: Functional interactions in cytochrome P450BM3. Fatty acid substrate binding alters electron-transfer properties of the flavoprotein domain. Biochemistry, 35, 15029–15037 (1996)

    Article  PubMed  CAS  Google Scholar 

  72. McGuire, J.J.; Anderson, D.J.; McDonald, B.J.; Narayanasami, R.; Bennett, B.M.: Inhibition of NADPH-cytochrome P450 reductase and glyceryl trinitrate biotransformation by diphenyleneiodonium sulfate. Biochem. Pharmacol., 56, 881–893 (1998)

    Article  PubMed  CAS  Google Scholar 

  73. Pritchard, M.P.; Glancey, M.J.; Blake, J.A.R.; Gilham, D.E.; Burchell, B.; Wolf, C.R.; Friedberg, T.: Functional co-expression of CYP2D6 and human NADPH-cytochrome P450 reductase in Escherichia coli. Pharmacogenetics, 8, 33–42 (1998)

    Article  PubMed  CAS  Google Scholar 

  74. Venkateswarlu, K.; Lamb, D.C.; Kelly, D.E.; Manning, N.J.; Kelly, S.L.: The Nterminal membrane domain of yeast NADPH-cytochrome P450 (CYP) oxidoreductase is not required for catalytic activity in steril biosynthesis or in reconstitution of CYP activity. J. Biol. Chem., 273, 4492–4496 (1998)

    Article  PubMed  CAS  Google Scholar 

  75. Shen, A.L.; Porter, T.D.; Wilson, T.E.; Kasper, C.B.: Structural analysis of the FMN binding domain of NADPH-cytochrome P-450 oxidoreductase by site-directed mutagenesis. J. Biol. Chem., 264, 7584–7589 (1989)

    PubMed  CAS  Google Scholar 

  76. Shen, A.L.; Kasper, C.B.: Differential contributions of NADPH-Cytochrome P450 oxidoreductase FAD binding site residues to flavin binding and catalysis. J. Biol. Chem., 275, 41087–41091 (2000)

    Article  PubMed  CAS  Google Scholar 

  77. Menting, J.G.T.; Cornish, E.; Scopes, R.K.: Purification and partial characterization of NADPH-cytochrome c reductase from Petunia hybrida flowers. Plant Physiol., 106, 643–650 (1994)

    Article  PubMed  CAS  Google Scholar 

  78. Stiborova, M.; Schmeiser, H.H.; Frei, E.: Oxidation of xenobiotics by plant microsomes, a reconstituted cytochrome P450 system and peroxidase: a comparative study. Phytochemistry, 54, 353–362 (2000)

    Article  PubMed  CAS  Google Scholar 

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(2005). NADPH-Ferrihemoprotein reductase. In: Schomburg, D., Schomburg, I. (eds) Springer Handbook of Enzymes. Springer Handbook of Enzymes, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-37662-3_6

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