Zusammenfassung
Bakterien, die den Darm besiedeln und durch Invasion in die Epithelzellen oder Überschreiten der intestinalen Barriere Diarrhö und Gastroenteritiden auslösen, sind bedeutende Krankheitserreger in Industrie- und Entwicklungsländern. Laut Bericht der WHO gab es 1999 aufgrund von Durchfallerkrankungen über 2,2 Mio. Todesfälle weltweit (World Health Report 2000). Wichtige Pathogenitätsfaktoren sind die von den Mikroorganismen gebildeten Enterotoxine, fast ausschließlich Proteine, die für die Entstehung der Darmerkrankungen und Diarrhöen verantwortlich sind.
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Literatur
Aepfelbacher M., Zumbihl R., Ruckdeschel K. et al. (2000) Translocated toxins and modulins of Yersinia. Aktories K. and Just I. Bacterial Protein Toxins. Chapter 28, 669–685
Aktories K. (1994) Clostridial ADP-ribosylating toxins: effects on ATP and GTP binding toxins. MolCell Biol 138, 167–176.
Aktories K., Schmidt G., Just I. (2000) Rho GTPases as targets of bacterial protein toxins. Biol Chem 381, 421–426
Alouf J.E., Freer J.H. (eds) (1999) The Comprehensive Sourcebook of Bacterial Protein Toxins. Academic Press.
Asao T., Kinoshita Y., Kozaki S. et al. (1984) Purification and some properties of Aeromonas hydrophila hemolysin. Infect Immun, 122–127
Beecher D.J., Schoeni J.L., Wong C.L. (1994) Enterotoxic activity of hemolysin BL from Bacillus cereus. Infect Immun 63, 4423–4428
Bhakdi S., Tranum-Jensen J. (1991) Alpha-toxin of Staphylococcus aureus. Microbiol Rev 55, 733–751
Boquet P. (2000) The cytotoxic necrotizing factor 1 (CNF1) from uropathogenic Escherichia coli. Adv Exp Med Biol 485, 45–51
Busch C., Aktories K. (2000) Microbial toxins and the glycosylation of Rho family GTPases. Curr Opin Struct Biol 10, 528–535
Chopra A.K., Houston W.C. (1999) Enterotoxins in Aeromonas-associated gastroenteritis. Microb Infect 1, 1129–1137.
Cornelis G.R. (2000) Molecular and cell biology aspects of plague. PNAS 97, 8778–8783
Cossart P., Boquet P., Normark S., Rappuoli R. (2000) Cellular Microbiology. ASM Press
Delor I., Cornelis G.R. (1992) Role of Yersinia enterocolitica Yst toxin in experimental infection in young rabbits. Infect Immun 60, 4269–4277
Estes M.K., Morris A.P. (1999) A viral enterotoxin. In: Paul, Francis (eds) Mechanisms in the Pathogenesis of Enteric Deseases. New York, Kluwer Academic / Plenum Publishers, 73–82
Fasao A (1999) Intestinal toxins. Curr Opin Gastroenterol 15, 523–528
Gerhard R., Schmidt G., Hofmann F., Aktories K (1998) Activation of Rho GTPases by Escherichia coli Cytotoxic Necrotizing Factor 1 increases intestinal permeability in Cco-2 cells. Infect Immun 66, 5125–5131
Giannella R.A. (1995) Escherichia coli heat stable enterotoxins, guanylins, and their receptors: what are they and do they do. J Lab Clin Med 125, 173–181
Granum P.E., Granum L., Granum T. (1997) Bacillus cereus and its food poisoning toxins. FEMS Microbiol Letter 157(2), 223–228
Hatheway C.L. (1990) Toxigenic Clostridia. Clin Microbiol Rev 3, 66–98
James S.P. (1993) Potential role of superantigens in gastrointestinal desease. Gastroenterology 105, 1569–1571
Just I., Hofmann F., Aktories K. (2000) Molecular Mechanisms of Action of the large clostridial cytotoxins. Aktories K. and Just I. Bacterial Protein Toxins. Springer, Berlin Heidelberg, S. 307–327
Just I, Gerhard R (2004) Large clostridial cytotoxins. Rev Physiol Biochem Pharmacol 152, 23–47
Kaper J.B., Fasao A., Trucksis M. (1994) Toxins of Vibrio cholerae. In: Wachsmuth I.K., Blake P.A., Olsvik O. (eds.) Vibrio cholera and cholera. American Society for Microbiology, Washington, D.C., 145–176
Law D. (2000) Virulence factors of Escherichia coli O157 and other Shiga toxin-producing E. coli. J Appl Microbiol 88, 729–745
Matthews B.G., Douglas H., Guiney D.G. (1988) Production of a heat stable enterotoxin by Plesiomonas shigelloides. Microb Pathog 5, 207–213
Melton-Celsa AR, O’Brian AD (2000) Shiga toxins of Shigella dysenteriae and Escherichia coli. In: Aktories K, Just I (eds) Bacterial Protein Toxins. Springer, Berlin Heidelberg, S. 385–431
Nakao H, Takeda T (2000) Escherichia coli Shiga toxin. J Nat Tox 9, 299–313
O’Loughlin EV, Robins-Browne RM (2001) Effect of Shiga toxin and Shiga-like toxins on eukaryotic cells. Microb Infect 3, 493–507
Patton WA, Vitale N, Moss J, Vaughan M (2000) Mechanisms of cholera toxin action: ADP-ribosylation factors as stimulators of cholera toxin-catalized ADP-ribosylation and effectors in intracellular vesicular trafficking events. In: Aktories K, Just I (eds) Bacterial Protein Toxins. Springer, Berlin Heidelberg, S. 133–152
Popoff MR, Milward FW, Bancillon B, Boquet P (1988) Actin-specific ADP-ribosyltransferase produced by a Clostridium difficile strain. Infect Immun 56, 2299–2306
Pothoulakis C., Lamont JT (2001) Microbes and Microbial Toxins: Paradigms for Microbial-Mucosal Interactions II. The integrated response of the intestine to Clostridium difficile toxins. Am J of Physiol 280, G178–G183
Rupnik, M, Dupuy B, Fairweather NF et al. (2005) Revised nomenclature of Clostridium difficile toxins and associated genes. J Med Microbiol 54, 113–117
Sears CL, Kaper JB (1996) Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion. Microbiol Rev 60, 167–215
Sukhan A (2000) The invasion-associated type III secretion system of Salmonella typhimurium: common and unique features. Cellular and Molecular Lif Sci 57, 1033–1049
Wassenaar TM (1997) Toxin production by Campylobacter spp. Clinical Microbiol Rev 10, 466–476
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Gerhard, R., Just, I. (2006). Bakterielle Enterotoxine. In: Caspary, W.F., Kist, M., Stein, J. (eds) Infektiologie des Gastrointestinaltraktes. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-37211-3_3
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