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Literatur
Abrahamse SL, Bindels RJ, van Os CH (1992) The colon carcinoma cell line Caco-2 contains an H+/K+-ATPase that contributes to intracellular pH regulation. Pflugers Arch 421: 591–597
Abuladze N, Lee I, Newman D et al. (1998) Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter. J Biol Chem 273: 17689–17695
Agarwal R, Afzalpurkar R, Fordtran JS (1994) Pathophysiology of potassium absorption and secretion by the human intestine. Gastroenterology 107: 548–571
Agnel M, Vermat T, Culouscou J M (1999) Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea. FEBS Lett 455: 295–301
Aktories K, Schmidt G, Just I (2000) Rho GTPases as targets of bacterial protein toxins. Biol Chem 381: 421–426
Alper S, Rossmann H, Wilhelm S et al. (1999) Expression of AE2 anion exchanger in mouse intestine. Am J Physiol 277: G321–332
Alper SL (1991) The band 3-related anion exchanger (AE) gene family. Annu Rev Physiol. 53: 549–564
Alvarez de la Rosa D, Canessa C M, Fyfe G K, Zhang P (2000) Structure and regulation of amiloride-sensitive sodium channels. Annu Rev Physiol 62: 573–594
Amasheh S, Epple H J, Mankertz J et al. (2000) Differential regulation of ENac by aldosterone in rat early and late distal colon. Ann N Y Acad Sci 915: 92–94
Ameen N A, Ardito T, Kashgarian M, Marino CR (1995) A unique subset of rat and human intestinal villus cells express the cystic fibrosis transmembrane conductance regulator. Gastroenterology: 1016–1023
Amlal H, Wang Z, Burnham C, Soleimani, M (1998) Functional characterization of a cloned human kidney Na+:HCO3-cotransporter. J Biol Chem 273: 16810–16815
Asher C, Wald H, Rossier B C, Garty, H (1996) Aldosterone-induced increase in the abundance of Na+ channel subunits. Am J Physiol 2: C605–C611
Atisook K, Madara J L (1991) An oligopeptide permeates intestinal tight junctions at glucose-elicited dilatations. Implications for oligopeptide absorption. Gastroenterology 100: 719–724
Bachmann O, Rossmann H, Wüchner, K et al. (2001) NHE2 is the predominant pHPi regulator in murine colonic crypt cells. Gastroenterology 120: A 3775
Bachmann O, Sonnentag T, Siegel W K et al. (1998) Different acid secretagogues activate different Na+/H+ exchanger isoforms in rabbit parietal cells. Am J Physiol 38: G1085–G1093
Bakker R, Groot JA (1984) cAMP-mediated effects of ouabain and theophylline on paracellular ion selectivity. AmJ Physiol 246: G213–G217
Balda MS, Matter K (1998) Tight junctions. J Cell Sci 111 (Pt 5): 541–547
Bugaut M (1987) Occurrence, absorption and metabolism of short chain fatty acids in the digestive tract of mammals. Comp Biochem Physiol [B] 86: 439–472
Bernardo AA, Kear FT, Santos AVP et al. (1999) Basolateral Na+/HCO3-cotransport activity is regulated by the dissociable Na+/H+ exchanger regulatory factor. J Clin Invest 104: 195–201
Biemesderfer D, DeGray B, Aronson, PS (1998) Membrane topology of NHE3. Epitopes within the carboxyl-terminal hydrophilic domain are exoplasmic. J Biol Chem 273: 121–126
Bijlsma PB, Bakker R, Groot J A (1997) The chloride conductance of tight junctions of rat ileum can be increased by cAMP but not by carbachol. J Membr Biol 157: 127–137
Bijlsma, P B, Kiliaan AJ, Scholten G et al. (1996). Carbachol, but not forskolin, increases mucosal-to-serosal transport of intact protein in rat ileum in vitro. Am J Physiol 2: G147–G155
Binder HJ, Foster, ES, Budinger ME, Hayslett JP (1987) Mechanism of electroneutral sodium chloride absorption in distal colon of the rat. Gastroenterology: 449–455
Binder H J, McGlone F, Sandle GI (1989) Effects of corticosteroid hormones on the electrophysiology of rat distal colon: implications for Na+ and K+ transport. J Physiol (Lond) 0: 425–441
Binder HJ, Sangan P, Rajendran VM (1999) Physiological and molecular studies of colonic H+,K+-ATPase. Semin Nephrol 19: 405–414
Breton S, Wiederhold T, Marshansky V et al. (2000) The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells. J Biol Chem 275: 18219–18224
Brown D, Breton S (2000) Sorting proteins to their target membranes. Kidney Int 57: 816–824
Bry L, Falk P, Huttner K et al. (1994) Paneth cell differentiation in the developing intestine of normal and transgenic mice. Proc Natl Acad Sci USA 91: 10335–10339
Burnham CE, Amlal H, Wang Z et al. (1997) Cloning and functional expression of a human kidney Na+:HCO3-cotransporter. J Biol Chem 272: 19111–19114
Canessa C M, Schild L, Buell G et al. (1997) Rossier. Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits [see comments]. Nature 7: 463–467
Chao A, de-Sauvage CFJ, Dong YJ et al. (1994) Activation of intestinal CFTR Cl-channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase. EMBO J 13: 1065–1072
Chow CW, Woodside M, Demaurex N et al. (1999) Proline-rich motifs of the Na+/H+ exchanger 2 isoform — Binding of Src homology domain 3 and role in apical targeting in epithelia. J Biol Chem 274: 10481–10488
Clarke LL, Grubb BR, Yankaskas JR et al. (1994) Relationship of a noncystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice. Proc Natl Acad Sci USA 91: 479–483
Clarke LL, Harline MC, Gawenis LR et al. (2000) Extracellular UTP stimulates electrogenic bicarbonate secretion across CFTR knockout gallbladder epithelium. Am J Physiol 279: G132–G138
Cohen M E, Wesolek J, McCullen J et al. (1991) Carbachol-and elevated Ca2+-induced translocation of functionally active protein kinase C to the brush border of rabbit ileal Na+ absorbing cells. J Clin Invest 88: 855–863
Cooke HJ (1994) Neuroimmune signaling in regulation of intestinalion transport. Am J Physiol 266: G167–G178
Counillon L, Pouyssegur J (2000) The expanding family of eukaryotic Na+/H+ exchangers. J Biol Chem 275: 1–4
Coupaye-Gerard B, Bookstein C, Duncan P et al. (1996) Biosynthesis and cell surface delivery of the NHE1 isoform of Na+/H+ exchanger in A6 cells. Am J Physiol 2: C1639–C1645
Cuthbert AW, Halstead J, Ratcliff R et al. (1995) The genetic advantage hypothesis in cystic fibrosis heterozygotes: a murine study. J Physiol (Lond) 482 (Pt 2): 449–454
Cuthbert AW, MacVinish LJ, Hickman ME et al. (1994) Iontransporting activity in the murine colonic epithelium of normal animals and animals with cystic fibrosis. Pflugers Arch 428: 508–515, 19
Darmoul D, Ouellette AJ (1996) Positional specificity of defensin gene expression reveals Paneth cell heterogeneity in mouse small intestine. Am J Physiol 2: G68–G74
Del CJ, Rajendran VM, Binder HJ (1991) Apical membrane localization of ouabain-sensitive K+-activated ATPase activities in rat distal colon. Am J Physiol: G1005–G1011
Dharmsathaphorn K, Mandel K G, Masui H, McRoberts JA (1985) Vasoactive intestinal polypeptide-induced chloride secretion by a colonic epithelial cell line. Direct participation of a basolaterally localized Na+,K+,Cl-cotransport system. J Clin Invest 75: 462–471
DiBona DR, Mills JW (1979) Distribution of Na+-pump sites in transporting epithelia. Fed Proc 38: 134–143
Donowitz M, Cohen ME, Gould M, Sharp GW (1989) Elevated intracellular Ca2+ acts through protein kinase C to regulate rabbit ileal NaCl absorption. Evidence for sequential control by Ca2+/calmodulin and protein kinase C. J Clin Invest 83: 1953–1962
Duc C, Farman N, Canessa CM et al. (1994) Cell-specific expression of epithelial sodium channel alpha, beta, and gamma subunits in aldosterone-responsive epithelia from the rat: localization by in situ hybridization and immunocytochemistry. J Cell Biol 127: 1907–1921
Epple H J, Amasheh S, Mankertz J et al. (2000) Early aldosterone effect in distal colon by transcriptional regulation of ENac subunits. Am J Physiol 278: G718–G724
Fanning AS, Jameson BJ, Jesaitis LA, Anderson JM (1998) The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton. J Biol Chem 273: 29745–29753
Farthing MJ (2000) Enterotoxins and the enteric nervous system — a fatal attraction. Int J Med Microbiol 2: 491–496
Ferraris RP, Diamond J (1997) Regulation of intestinal sugar transport. Physiol Rev 77: 257–302
Firsov D, Gautschi I, Merillat AM et al. (1998) The heterotetrameric architecture of the epithelial sodium channel (ENac). EMBO J 17: 344–352
Fisher RS, Grillo FG, Sariban-Sohraby S (1996) Brefeldin A inhibition of apical Na+ channels in epithelia. Am J Physiol 270: C138–C147
Flagella M, Clarke LL, Miller ML et al. (1999) Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf. J Biol Chem 274: 266–265
Forte LR, Eber SL, Turner JT et al. (1993) Guanylin stimulation of Clsecretion in human intestinal T84 cells via cyclic guanosine monophosphate. J Clin Invest 91: 2423–2428
Foster ES, Dudeja PK, Brasitus T (1990) Contribution of Cl-OH-exchange to electroneutral NaCl absorption in rat distal colon. Am J Physiol 258: G261–G267
Foster ES, Jones WJ, Hayslett JP, Binder, HJ (1985) Role of aldosterone and dietary potassium in potassium adaptation in the distal colon of the rat. Gastroenterology 88: 41–46
Frigeri A, Gropper MA, Turck CW, Verkman AS (1995) Immunolocalization of the mercurial-insensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes. Proc Natl Acad Sci USA 92: 4328–4331
Fujita K, Katahira J, Horiguchi Y et al. (2000) Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein. FEBS Lett 4: 258–261
Furuse M, Sasaki H, Fujimoto K, Tsukita, S (1998) A single gene product, claudin-1 or-2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J Cell Biol 143: 391–401
Fyfe GK, Canessa CM (1998) Subunit composition determines the single channel kinetics of the epithelial sodium channel. J Gen Physiol 112: 423–432
Gadsby DC, Nairn AC (1999) Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis. Physiol Rev 79: S77–S107
Gallardo P, Cid LP, Vio CP, Sepulveda FV (2001) Aquaporin-2, a regulated water channel, is expressed in apical membranes of rat distal colon epithelium. Am J Physiol 281: G856–G863
Genth H, Aktories K, Just I (1999) Monoglucosylation of RhoA at threonine 37 blocks cytosol-membrane cycling. J Biol Chem 274: 29050–29056
Giaroni C, De Ponti F, Cosentino M et al. (1999) Plasticity in the enteric nervous system. Gastroenterology: 1438–1458
Gisler SM, Stagljar I, Traebert M et al. (2001) Interaction of the type IIa Na/Pi cotransporter with PDZ proteins. J Biol Chem 2: 9206–9213
Goulet CC, Volk KA, Adams CM et al. (1998) Snyder. Inhibition of the epithelial Na+ channel by interaction of Nedd4 with a PY motif deleted in Liddle’s syndrome. J Biol Chem 273: 30012–30017
Greger R (2000) Role of CFTR in the colon. Annu Rev Physiol 62: 467–491
Greig E, Sandle, GI (2000) Diarrhea in ulcerative colitis. The role of altered colonic sodium transport. Ann N Y Acad Sci 915: 327–332
Gross E, Abuladze N, Pushkin A et al. (2001) The stoichiometry of the electrogenic sodium bicarbonate cotransporter pNBC1 in mouse pancreatic duct cells is 2 HCO3-:1 Na+. J Physiol 531: 375–382
Grotjohann I, Schmitz H, Fromm M, Schulzke JD (2000) Effect of TNF alpha and IFN gamma on epithelial barrier function in rat rectum in vitro. Ann NY Acad Sci 915: 282–286
Grubb BR, Boucher RC (1999) Pathophysiology of gene-targeted mouse models for cystic fibrosis. Physiol Rev 79: S1–S214
Guba M, Kuhn M, Forssmann WG et al. (1996) Guanylin strongly stimulates rat duodenal HCO3-secretion: proposed mechanism and comparison with other secretagogues [see comments]. Gastroenterology 111: 1558–1568
Haas M, Forbush B (2000) The Na-K-Cl cotransporter of secretory epithelia. Annu Rev Physiol 62: 515–534
Hansen O (2001) The alpha1 isoform of Na+,K+-ATPase in rat soleus and extensor digitorum longus. Acta Physiol Scand 173: 335–341
Hediger MA, Rhoads DB (1994) Molecular physiology of sodium-glucose cotransporters. Physiol Rev 74: 993–1026
Hirsch JR, Loo DDF, Wright EM (1996) Regulation of Na+/glucose cotransporter expression by protein kinases in Xenopus laevis oocytes. J Biol Chem 2: 14740–14746
Hoogerwerf WA, Tsao SC, Devuyst O et al. (1996) NHE2 and NHE3 are human and rabbit intestinal brush-border proteins. Am J Physiol 270: G29–G41
Howard M, Jilling T, DuVall M, Frizzell RA (1996) cAMP-regulated trafficking of epitop-tagged CFTR. Kidney Int 49: 1642–1648
Hug MJ, Thiele IE, Greger R (1997) The role of exocytosis in the activation of the chloride conductance in Chinese hamster ovary cells (CHO) stably expressing CFTR. Pflugers Arch 434: 779–784
Inai T, Kobayashi J, Shibata Y (1999) Claudin-1 contributes to the epithelial barrier function in MDCK cells. Eur J Cell Biol 78: 849–855
Ishiguro H, Steward MC, Wilson RW, Case RM (1996) Bicarbonate secretion in interlobular ducts from guinea-pig pancreas. J Physiol Lond 4: 179–191
Itoh M, Furuse M, Morita K et al. (1999) Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol 147: 1351–1363
Jacob P, Christiani S, Rossmann H et al. (2000) Role of Na+HCO3-cotransporter NBC1, Na+/H+exchanger NHE1 and carbonic anhydrase in rabbit duodenal bicarbonate secretion. Gastroenterology 119: 406–419
Jacob P, Rossmann H, Lamprecht G et al. (2002) Down-regulated in adenoma mediates apical Cl-/HCO3-exchange in rabbit, rat and human duodenum. Gastroenterology 122: 709–724
Janecki AJ, Montrose MH, Zimniak P et al. (1998) Subcellular redistribution is involved in acute regulation of the brush border Na+/H+exchanger isoform 3 in human colon adenocarcinoma cell line Caco-2. Protein kinase C-mediated inhibition of the exchanger. J Biol Chem 273: 8790–8798
Jarchau T, Hausler C, Markert T et al. (1994) Cloning, expression, and in situ localization of rat intestinal cGMP-dependent protein kinase II. Proc Natl Acad Sci USA 91: 26–30
Joo NS, Clarke LL, Han BH et al. (1999) Cloning of ClC-2 chloride channel from murine duodenum and its presence in CFTR knockout mice. Biochim Biophys Acta 1446: 431–437
Kaplan JH (1983) Sodium ions and the sodium pump: transport and enzymatic activity. Am J Physiol 245: G327–G333
Kaunitz JD, Sachs, G (1986) Identification of a vanadate-sensitive potassium-dependent proton pump from rabbit colon. J Biol Chem: 14005–14010
Kiliaan AJ, Scholten G, Bijlsma PB et al. (1996) Influence of forskolin and carbachol on intestinal absorption of horseradish peroxidase in the goldfish (Carassius auratus). Cell Tissue Res 2: 51–56
Kimmich GA, Randles J (1984) Sodium-sugar coupling stoichiometry in chick intestinal cells. Am J Physiol: C74–C82
Kockerling A, Fromm M (1993) Origin of cAMP-dependent Cl-secretion from both crypts and surface epithelia of rat intestine. Am J Physiol 264: C1294–C1301
Kopito RR (1990) Molecular biology of the anion exchanger gene family. Int Rev Cytol: 177–199
Kosari F, Sheng S, Li J et al. (1998) Subunit stoichiometry of the epithelial sodium channel. J Biol Chem 273: 13469–13474
Koyama Y, Yamamoto T, Tani T et al. (1999) Expression and localization of aquaporins in rat gastrointestinal tract. Am J Physiol 2: C621–C627
Kudrycki KE, Newman PR, Shull GE (1990) cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3-exchanger. J Biol Chem: 462–471
Lamont JT (1992) Mucus: the front line of intestinal mucosal defense. Ann NY Acad Sci 664: 1190–201
Lamprecht G, Weinman EJ, Yun CHC (1998) The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3. J Biol Chem 273: 29972–29978
Ledoussal C, Lorenz JN, Nieman ML et al. (2001) Shull. Renal salt wasting in mice lacking NHE3 Na+/H+ exchanger but not in mice lacking NHE2. Am J Physiol 281: F718–F727
Lohmann SM, Vaandrager AB, Smolenski A et al. (1997) Distinct and specific functions of cGMP-dependent protein kinases. Trends Biochem Sci 22: 307–312
Lomax RB, McNicholas CM, Lombes M, Sandle GI (1994) Aldosterone-induced apical Na+ and K+ conductances are located predominantly in surface cells in rat distal colon. Am J Physiol 266: G71–G82
Lundgren O (1998) 5-Hydroxytryptamine, enterotoxins, and intestinal fluid secretion. Gastroenterology 115: 1009–1012
Ma T, Yang B, Gillespie A et al. (1997) Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4. J Clin Invest 1000: 957–962
Markert T, Vaandrager AB, Gambaryan S et al. (1995) Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulator. J Clin Invest 96: 822–830
Matthews JB, Smith JA, Nguyen H (1995) Modulation of intestinal chloride secretion at basolateral transport sites: opposing effects of cyclic adenosine monophosphate and phorbol ester. Surgery 118: 147–152
McNicholas CM, Canessa CM (1997) Diversity of channels generated by different combinations of epithelial sodium channel subunits. J Gen Physiol 109: 681–692
Melvin JE, Park K, Richardson L et al. (1999) Mouse down-regulated in adenoma (DRA) is an intestinal Cl-/HCO3-exchanger and is upregulated in colon of mice lacking the NHE3 Na+/H+ exchanger. J Biol Chem 274: 225–228
Mitic LL, Van Itallie CM, Anderson JM (2000) Molecular physiology and pathophysiology of tight junctions I. Tight junction structure and function: lessons from mutant animals and proteins. Am J Physiol 279: G250–G254
Montrose MH, Keely SJ, Barrett KE (1999) Electrolyte Secretion and Absorption: Small Intestine and Colon. In Yamada T, Alpers DH, Laine L (eds) Textbook of Gastroenterology. Lippincott Williams & Wilkins, pp 320–355
Morita K, Furuse M, Fujimoto K, Tsukita S (1999) Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci USA 96: 511–516
Morris AP, Cunningham SA, Benos DJ, Frizzell RA (1992) Cellular differentiation is required for cAMP but not Ca2+-dependent Cl-secretion in colonic epithelial cells expressing high levels of cystic fibrosis transmembrane conductance regulator. J Biol Chem 267: 5575–5583
Nielsen S, Smith BL, Christensen EI, Agre P (1993) Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia. Proc Natl Acad Sci USA: 7275–7279
Noel J, Pouyssegur J (1995) Hormonal regulation, pharmacology, and membrane sorting of vertebrate Na+/H+ exchanger isoforms. Am J Physiol 268: C283–296
Nusrat A, Parkos CA, Bacarra A et al. (1994) Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and induction of rapid wound repair in a transformed model epithelium. J Clin Invest: 56–65
Nusrat A, Turner JR, Madara JL (2000) Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells. Am J Physiol 279: G851–G857
Peregrin AT, Ahlman H, Jodal M, Lundgren O (1999) Involvement of serotonin and calcium channels in the intestinal fluid secretion evoked by bile salt and cholera toxin. Br J Pharmacol 127: 887–894
Pfeifer A, Aszodi A, Seidler U et al. (1996) Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. Science 274: 2082–2086
Podolsky DK (1993) Regulation of intestinal epithelial proliferation: a few answers, many questions. Am J Physiol 264: G179–G186
Quinton PM (1999) Physiological basis of cystic fibrosis: a historical perspective. Physiol Rev 79: S3–S22
Raghuram V, Mak DD, Foskett JK (2001) Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction. Proc Natl Acad Sci USA 98: 1300–1305
Rajendran VM, Binder HJ (1993) Cl-HCO3 and Cl-OH exchanges mediate Cl uptake in apical membrane vesicles of rat distal colon. Am J Physiol 264: G874–G879
Rocha F, Musch MW, Lishanskiy L et al. (2001) IFN-gamma downregulates expression of Na+/H+ exchangers NHE2 and NHE3 in rat intestine and human Caco-2/bbe cells. Am J Physiol 280: C1224–C1232
Romero MF, Boron WF (1999) Electrogenic Na+/HCO3-cotransporters: Cloning and physiology. Ann Rev Physiol: 699–723
Rossmann H, Sonnentag T, Heinzmann A et al. (2001) Differential expression and regulation of Na+/H+ exchanger isoforms in rabbit parietal and mucous cells. Am J Physiol 281: G447–G458
Saitou M, Fujimoto K, Doi Y et al. (1998) Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions. J Cell Biol 1: 397–408
Sardet C, Counillon L, Franchi A, Pouyssegur J (1990) Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD. Science: 723–726
Schmitz H, Barmeyer C, Gitter A H et al. (2000). Epithelial barrier and transport function of the colon in ulcerative colitis. Ann NY Acad Sci 915: 312–326
Schmitz H, Fromm M, Bentzel CJ et al. (1999) Tumor necrosis factoralpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6. J Cell Sci 112 (Pt 1): 137–146
Schroeder BC, Waldegger S, Fehr S et al. (2000) A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 403: 196–199
Schultheis PJ, Clarke LL, Meneton P et al. (1998a) Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger. Nat Genet 19: 282–285
Schultheiss G, Horger S, Diener M (1998b) The bumetanide-resistant part of forskolin-induced anion secretion in rat colon. Acta Physiol Scand 164: 219–228
Schwiebert EM, Benos DJ, Egan ME et al. (1999) CFTR is a conductance regulator as well as a chloride channel. Physiol Rev 79: S145–S166
Sears CL (2000) Molecular physiology and pathophysiology of tight junctions V. assault of the tight junction by enteric pathogens. Am J Physiol 279: G1129–G1134
Seidler U, Bachmann O, Jacob P et al. (2001) Na+/HCO3-cotransport in normal and cystic fibrosis intestine. JOP J Pancreas 2 (online): 247–2
Seidler U, Rossmann H, Jacob P et al. (2000) Expression and function of Na+HCO3-cotransporters in the gastrointestinal tract. Ann NY Acad Sci 915: 1–14
Seki G, Coppola S, Fromter E (1993) The Na(+)-HCO3-cotransporter operates with a coupling ratio of 2 HCO3-to 1 Na+ in isolated rabbit renal proximal tubule. Pflugers Arch 425: 409–416
Sheng M, Pak DT (2000) Ligand-gated ion channel interactions with cytoskeletal and signaling proteins. Annu Rev Physiol 62: 755–778
Sheng M Sala C (2001) PDZ domains and the organization of supramolecular complexes. Annu Rev Neurosci 24: 1–29
Sheppard DN, Welsh MJ (1999) Structure and function of the CFTR chloride channel. Physiol Rev 79: S23–S45
Silberg DG, Wang W, Moseley RH, Traber PG (1986) The Down regulated in Adenoma (dra) gene encodes an intestine-specific membrane sulfate transport protein. J Biol Chem 270: 11897–11902
Sonnentag T, Siegel WK, Bachmann O et al. (2000) Agonist-induced cytoplasmic volume changes in cultured rabbit parietal cells. Am J Physiol 279: G40–G48
Strong TV, Boehm K, Collins FS (1994) Localization of cystic fibrosis transmembrane conductance regulator mRNA in the human gastrointestinal tract by in situ hybridization. J Clin Invest: 347–3
Stutts MJ, Canessa CM, Olsen JC et al. (1995) CFTR as a cAMP-dependent regulator of sodium channels. Science 269: 847–850
Sugi K, Musch M W, Field M, Chang E B (2001) Inhibition of Na(+),K(+)-ATPase by Interferon gamma Down-regulates Intestinal Epithelial Transport and Barrier Function. Gastroenterology 120: 1393–1403
Sun F, Hug MJ, Lewarchik CM et al. (2000) E3KARP mediates the association of ezrin and protein kinase A with the cystic fibrosis transmembrane conductance regulator in airway cells. J Biol Chem 275: 29539–29546
Suzuki Y, Kaneko K (1989) Ouabain-sensitive H+-K+ exchange mechanism in the apical membrane of guinea pig colon. Am J Physiol 256: G979–G988
Tai YH, Flick J, Levine SA et al. (1996) Regulation of tight junction resistance in T84 monolayers by elevation in intracellular Ca2+: a protein kinase C effect. J Membr Biol 149: 71–79
Takahashi A, Watkins SC, Howard M, Frizzell RA (1996) CFTR-dependent membrane insertion is linked to stimulation of the CFTR chloride conductance. Am J Physiol 2: C1887–C1894
Thorens B (1993) Facilitated glucose transporters in epithelial cells. Annu Rev Physiol 55: 591–608
Tse CM, Levine SA, Yun CH et al. (1993) Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2). J Biol Chem 268: 11917–11924
Tsukita S, Furuse M (1999) Occludin and claudins in tight-junction strands: leading or supporting players? Trends Cell Biol 9: 268–273
Tsukita S, Furuse M (2000) Pores in the wall: claudins constitute tight junction strands containing aqueous pores. J Cell Biol 149: 13–16
Turk E, Kerner CJ, Lostao MP, Wright EM (1996) Membrane topology of the human Na+/glucose cotransporter SGLT1. J Biol Chem 271: 1925–1934
Turk E, Zabel B, Mundlos S, Dyer J, Wright EM (1991) Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter. Nature 350–356
Turk E, Zabel B, Mundlos S et al. (1991) Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter. Nature 350: 354–356
Turner JR, Black ED, Ward J et al. (2000) Transepithelial resistance can be regulated by the intestinal brush-border Na+/H+ exchanger NHE3. Am J Physiol 279: C1918–C1924
Turner JR, Lencer WI, Carlson S, Madara JL (1996) Carboxy-terminal vesicular stomatitis virus G protein-tagged intestinal Na+-dependent glucose cotransporter (SGLT1): maintenance of surface expression and global transport function with selective perturbation of transport kinetics and polarized expression. J Biol Chem 2: 7738–7744
Turner JR, Rill BK, Carlson SL et al. (1997) Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation. Am J Physiol 273: C1378–C1385
Vaandrager AB, Bot AGM, Ruth P et al. (2000) Differential role of cyclic GMP-dependent protein kinase II in ion transport in murine small intestine and colon. Gastroenterology 118: 108–114
Vaandrager AB, Smolenski A, Tilly BC et al. (1998) Membrane targeting of cGMP-dependent protein kinase is required for cystic fibrosis transmembrane conductance regulator Cl-channel activation. Proc Natl Acad Sci USA: 1466–1471
Van Itallie C, Rahner C, Anderson JM (2001) Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. J Clin Invest 107: 1319–1327
Van Itallie CM, Balda MS, Anderson JM (1995). Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells. J Cell Sci (Pt 4): 1735–1742
Verkman AS, Mitra AK (2000) Structure and function of aquaporin water channels. Am J Physiol 278: F13–F28
Verrey F, Beron J, Spindler B (1996) Corticosteroid regulation of renal Na,K-ATPase. Miner Electrolyte Metab 22: 279–292
Wakabayashi S, Ikeda T, Iwamoto T et al. (1997) Calmodulin-binding autoinhibitory domain controls »pH-sensing« in the Na+/H+ exchanger NHE1 through sequence-specific interaction. Biochemistry 36: 12854–12861
Wakabayashi S, Shigekawa M, Pouyssegur J et al. (1997) Molecular physiology of vertebrate Na+/H+ exchangers. Physiol Rev 77: 51–74
Warth R, Hamm K, Bleich M et al. (1999) Molecular and functional characterization of the small Ca2+-regulated K+ channel (rSK4) of colonic crypts. Pflugers Arch 438: 437–444
Weinman EJ (2001) New functions for the NHERF family of proteins. J Clin Invest: 185–186
Welsh MJ, Smith PL, Fromm M, Frizzell RA (1982) Crypts are the site of intestinal fluid and electrolyte secretion. Science 218: 1219–1221
Welsh MJ (1987) Electrolyte transport by airway epithelia. Physiol Rev 67: 1143–1184
Wittchen ES, Haskins J, Stevenson BR (1999) Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3. J Biol Chem 274: 35179–35185
Wu Z, Nybom P, Magnusson KE (2000) Distinct effects of Vibrio cholerae haemagglutinin/protease on the structure and localization of the tight junction-associated proteins occludin and ZO-1. Cell Microbiol. 2: 11–17
Youakim A, Ahdieh M (1999) Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin. Am J Physiol 2: G1279–G1288
Yun CH, Oh S, Zizak M et al. (1977) cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein. Proc Natl Acad Sci USA 94: 3010–3015
Yun CH, Lamprecht G, Forster DV, Sidor A (1998) NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrin. J Biol Chem 273: 25856–25863
Zeuthen T (2000) Molecular water pumps. Rev Physiol Biochem Pharmacol 1: 97–151
Zizak MG, Lamprecht D, Steplock N et al. (1999) cAMP-induced phosphorylation and inhibition of Na+/H+ exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor. J Biol Chem 274: 53–58
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© 2006 Springer Medizin Verlag Heidelberg
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Seidler, U., Bachmann, O. (2006). Molekulare Mechanismen des intestinalen Wasser- und Elektrolyttransportes und der Barrierefunktion. In: Caspary, W.F., Kist, M., Stein, J. (eds) Infektiologie des Gastrointestinaltraktes. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-37211-3_2
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