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Paternal Dual Barrier by Ifg2-H19 and Dlk1-Gtl2 to Parthenogenesis in Mice

  • Conference paper
Stem Cells in Reproduction and in the Brain

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 60))

Abstract

The functional difference between the maternal and paternal genome, which is characterized by epigenetic modifications during gametogenesis, that is genomic imprinting, prevents mammalian embryos from parthenogenesis. Genomic imprinting leads to nonequivalent expression of imprinted genes from the maternal and paternal alleles. However, our research showed that alteration of maternal imprinting by oocyte reconstruction using nongrowing oocytes together with deletion of the H19 gene, provides appropriate expression of maternally imprinted genes. Here we discuss that further alteration of paternally imprinted gene expressions at chromosomes 7 and 12 allows the ng/fg parthenogenetic embryos to develop to term, suggesting that the paternal contribution is obligatory for the descendant.

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Authors and Affiliations

  1. Department of BioScience, Tokyo, University of Agriculture, Setagaya-ku, Tokyo, 156-8502, Japan

    T. Kono, M. Kawahara, Q. Wu, H. Hiura & Y. Obata

Authors
  1. T. Kono
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  2. M. Kawahara
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  3. Q. Wu
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  4. H. Hiura
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  5. Y. Obata
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Editor information

Editors and Affiliations

  1. Nihon Schering K.K. Research Center, BMA 3F, 1-5-5 Minatojima-minai-machi, Chuo-ku, Kobe, 650-0047, Japan

    J. Morser

  2. Center for Developmental Biology, 2-2-3 Minatojima minami-machi, Chuo-ku, Kobe, 650-0047, Japan

    S. -I. Nishikawa

  3. Max Planck Institute for Molecular Biomedicine, Mendelstr. 7, 48149, Münster, Germany

    H. R. Schöler

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© 2006 Springer-Verlag Berlin Heidelberg

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Kono, T., Kawahara, M., Wu, Q., Hiura, H., Obata, Y. (2006). Paternal Dual Barrier by Ifg2-H19 and Dlk1-Gtl2 to Parthenogenesis in Mice. In: Morser, J., Nishikawa, S.I., Schöler, H.R. (eds) Stem Cells in Reproduction and in the Brain. Ernst Schering Research Foundation Workshop, vol 60. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-31437-7_3

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