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The Stem Cell Continuum: A New Model of Stem Cell Regulation

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Stem Cells

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 174))

Abstract

Most models of hematopoiesis have been hierarchical in nature. This is based on a large volume of correlative data. Recent work has indicated that, at least at the stem/progenitor level, hematopoiesis may, in fact, be a continuum of transcriptional opportunity. The most primitive hematopoietic stem cells are either continually cycling at a slow rate or entering and exiting cell cycle. Associated with this cycle passage are changes in functional phenotype including reversible alterations in engraftment, adhesion protein expression, cytokine receptor expression, homing to marrow, and progenitor cell numbers. Global gene expression, as measured in one point in cycle, is also markedly altered. The differentiation potential of the marrow as it transits cell cycle in response to a set differentiation stimulus also shows marked variations. This cycle-related plasticity has been clearly established for hematopoiesis. It also holds for the ability of murine marrow stem cells to home to lung and to convert to pulmonary cells. These data indicate that bone marrow stem cells can probably not be defined as discrete entities but must rather be studied on a population basis. They also indicate that mathematical modeling will become progressively more important in this field.

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Authors and Affiliations

  1. Research Department, Roger Williams Medical Center, 825 Chalkstone Avenue, Providence, RI, 02908, USA

    P.J. Quesenberry, G.A. Colvin & M.S. Dooner

Authors
  1. P.J. Quesenberry
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  2. G.A. Colvin
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  3. M.S. Dooner
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Editor information

Editors and Affiliations

  1. In Vitro Differentiation Group, Dept. of Cytogenetics, Leibnitz Institute of Plant Genetics and Crop Plant Research (IPK), Corrensstr. 3, D-06466, Gatersleben, Germany

    Anna M. Wobus PhD

  2. Laboratory of Cardiovascular Science, Gerontology Research Program, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD, 21224, USA

    Kenneth R. Boheler PhD (Investigator) (Investigator)

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© 2006 Springer-Verlag Berlin Heidelberg

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Quesenberry, P., Colvin, G., Dooner, M. (2006). The Stem Cell Continuum: A New Model of Stem Cell Regulation. In: Wobus, A.M., Boheler, K.R. (eds) Stem Cells. Handbook of Experimental Pharmacology, vol 174. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-31265-X_8

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