This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Cordell GA (2000) Biodiversity and drug discovery — a symbiotic relationship. Phytochemistry 55:463–480
Fiehn O (2002) Metabolomics — the link between genotyopes and phenotypes. Plant Mol Biol 48:155–171
Gamborg OL, Miller RA, Ojima K (1968) Nutrient requirements of suspension cultures of soybean root cells. Exp Cell Res 50:151–158
Griffin JL, Bonney SA, Mann C, Hebbachi AM, Gibbons GF, Nicholson JK, Shoulders CC, Scott J (2004) An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver. Physiol Genomics 17:140–149
Hartemink AJ, Gifford DK, Jaakkola TS, Young RA (2001) Maximum likelihood estimation of optimal scaling factors for expression array normalization. SPIE BiOS, San Jose, California
Hirai MY, Yano M, Goodenowe DB, Kanaya S, Kimura T, Awazuhara M, Arita M, Fujiwara T, Saito K (2004) Integration of transcriptomics and metabolomics for understanding of global responses to nutritional stresses in Arabidopsis thaliana. Proc Natl Acad Sci USA 101:10205–10210
Hostettman K, Terreaux C (2000) Search for new lead compounds from higher plants. Chimia 54:652–657
Hyvärinen A, Oja E (2000) Independent component analysis: algorithms and applications. Neural Comput 5:411–430
Jackson JE (1991) User’s guide to principal components. Wiley, New York, NY
Jellum E (1977) Profiling of human body fluids in healthy and disease states using gas chromatography and mass spectrometry, with special reference to organic acids. J Chromatogr 143:427–462
Katajamaa M, Orešic M (2005) Processing methods for differential analysis of LC/MS profile data. BMC Bioinformatics 6:179.1–179.12
Kohonen T (2001) Self organizing maps. Springer, Berlin Heidelberg New York
Kose F, Weckwerth W, Linke T, Fiehn O (2001) Visualizing plant metabolomic correlation network using clique-metabolite matrices. Bioinformatics 17:1198–1208
Lee-Parsons CWT, Ertürk S, Tengtrakool J (2004) Enhancement of ajmalicine production in Catharanthus roseus cell cultures with methyl jasmonate is dependent on timing and dosage of elicitation. Biotechnol Lett 26:1595–1599
Memelink J, Verpoorte R, Kijne JW (2001) ORCAnization of jasmonate — responsive gene expression in alkaloid metabolism. Trends Plant Sci 6:212–219
Moreno PRH, van der Heijden R, Verpoorte R (1995) Cell and tissue-cultures of Cathar anthusroseus — a literature survey. 2. Updating from 1988 to 1993. Plant Cell Tissue Organ Cult 42:1–25
Newman DJ, Cragg GM, Snader KM (2003) Natural products as sources of new drugs over the period 1981–2002. J Nat Prod 66:1022–1037
Oksman-Caldentey K-M, Inzé D (2004) Plant cell factories in the post-genomic era: new ways to produce designer secondary metabolites. Trends Plant Sci 9:433–440
Oksman-Caldentey KM, Saito K (2005) Integrating genomics and metabolomics for engineering plant metabolic pathways. Curr Opin Biotechnol 16:174–179
Orešic M, Clish CB, Davidov EJ, Verheij E, Vogels JTWE, Havekes LM, Neumann E, Adourian A, Naylor S, van der Greef J, Plasterer T (2004) Phenotype characterization using integrated gene transcript, protein and metabolite profiling. Appl Bioinformatics 3:205–217
Pauw B, Hilliou FAO, Martin VS, Chatel G, de Wolf CJF, Champion A, Pre M, van Duijn B, Kijne JW, van der Fits L, Memelink J (2004) Zinc finger proteins act as transcriptional repressors of alkaloid biosynthesis genes in Catharanthus roseus. J Biol Chem 279:52940–52948
Reymond P, Farmer EE (1998) Jasmonate and salicylate as global signals for defense gene expression. Curr Opin Plant Biol 1:404–411
Sammon JW Jr (1969) A nonlinear mapping for data structure analysis. IEEE Trans Comp C-18:401–409
St-Pierre B, de Luca V (1995) A cytochrome-P-450 monooxygenase catalyzes the first step in the conversion of tabersonine to vindoline in Catharanthus roseus. Plant Physiol 109:131–139
St-Pierre B, Vazquez-Flota FA, De Luca V (1999) Multicellular compartmentation of Catharanthus roseus alkaloid biosynthesis predicts intercellular translocation of a pathway intermediate. Plant Cell 11:887–900
Tikhomiroff C, Jolicoeur M (2002) Screening of Catharanthus roseus secondary metabolites by high-performance liquid chromatography. J Chromatogr A 955:87–93
Van der Greef J, Tas AC, Bouwman J, Ten Noever de Brauw MC, Schreurs WHP (1983) Evaluation of field-desorption and fast atom-bombardment mass spectrometric profiles by pattern recognition techniques. Anal Chim Acta 150:45–52
Vazquez-Flota F, de Luca V, Carrillo-Pech M, Canto-Flick A, Miranda-Ham MD (2002) Vindoline biosynthesis is transcriptionally blocked in Catharanthus roseus cell suspension cultures. Mol Biotechnol 22:1–8
Verpoorte R (1998) Exploration of nature’s chemodiversity: the role of secondary metabolites as leads in drug development. Drug Discov Today 3:232–238
Verpoorte R (2000) Secondary metabolites. In: Verpoorte R, Alfermann AW (eds) Metabolic engineering of plant secondary metabolism. Kluwer Academic Publ, Dordrecht, pp 1–29
Weckwerth W, Loureiro ME, Wenzel K, Fiehn O (2004) Differential metabolic networks unravel the effects of silent plant phenotypes. Proc Natl Acad Sci USA 101:7809–7814
Whitmer S, van der Heijden R, Verpoorte R (2002) Effect of precursor feeding on alkaloid accumulation by a strictosidine synthase over-expressing transgenic cell line S1 of Catharanthus roseus. Plant Cell Tissue Organ Cult 69:85–93
Windig W, Meuzelaar HL (1984) Nonsupervised numerical component extraction from pyrolysis mass spectra of complex mixtures. Anal Chem 56:2297–303
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Orešic, M., Rischer, H., Oksman-Caldentey, K.M. (2006). Metabolomics of Plant Secondary Compounds: Profiling of Catharanthus Cell Cultures. In: Saito, K., Dixon, R.A., Willmitzer, L. (eds) Plant Metabolomics. Biotechnology in Agriculture and Forestry, vol 57. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29782-0_20
Download citation
DOI: https://doi.org/10.1007/3-540-29782-0_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-29781-9
Online ISBN: 978-3-540-29782-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)