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Hepatopulmonary syndrome

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Hepatology Principles and Practice

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References

Hepatopulmonary syndrome

  1. Abrams, G.A., Fallon, M.B.: Treatment of hepatopulmonary syndrome with Allium Sativum L. A pilot trial. J. Clin. Gastroenterol. 1998; 27: 232–235

    Article  CAS  PubMed  Google Scholar 

  2. Abrams, G.A., Nanda, N.C., Dubovsky, E.V., Krowka, M.J., Fallon, M.B.: Use of macroaggregated albumin lung perfusion scan to diagnose hepatopulmonary syndrome: a new approach. Gastroenterology 1998;114: 305–310

    Article  CAS  PubMed  Google Scholar 

  3. Aller, R., Moreira, V., Boixeda, D., Moya, J.L., de Luis, D.A., Enriquez, J.L., Fogué, L.: Diagnosis of hepatopulmonary syndrome with contrast transthoracic echocardiography and histological confirmation. Liver 1998; 18: 285–287

    CAS  PubMed  Google Scholar 

  4. Allgaier, H.-P., Haag, K., Blum, H.E.: Das hepatopulmonale Syndrom. Z. Gastroenterol. 1998; 36: 247–251

    CAS  PubMed  Google Scholar 

  5. Anel, R.M., Sheagren, J.N.: Novel presentation and approach to management of hepatopulmonary syndrome with the use of antimicrobial agents. Clin. Infect. Dis. 2001; 10: E 131–136

    Google Scholar 

  6. Baltzer, G., Arndt, H., Martini, G.A.: Sauerstoffuntersättigung und veränderte Hämodynamik bei Lebercirrhose. Klin. Wschr. 1973; 51: 1033–1042

    Article  Google Scholar 

  7. Berthelot, P., Walker, J.G., Sherlock, S., Reid, L.: Arterial changes in the lungs in cirrhosis of the liver — lung spider nevi. New Engl. J. Med. 1966; 274: 291–298

    CAS  PubMed  Google Scholar 

  8. Bindl, L., Wagner, N., Knöpfli, G., Gosseye, St., Lentze, M.J.: Peliosis hepatis with hepato-pulmonary syndrome. Klin. Paediatr. 1998; 210: 47–49

    CAS  Google Scholar 

  9. Cadranel, J.L., Milleron, B.J., Cadranel, J.F., Fermand, J.P., Andrivet, P., Brouet, J.C., Adnot, S., Akoun, G.M.: Severe hypoxemia-associated intrapulmonary shunt in a patient with chronic liver disease: improvement after medical treatment. Amer. Rev. Resp. Dis. 1992; 146: 526–527

    CAS  PubMed  Google Scholar 

  10. Caruso, G., Catalano, D.: Esophageal varices and hepatopulmonary syndrome in liver cirrhosis. J. Hepatol. 1991; 12: 262–263

    Article  CAS  PubMed  Google Scholar 

  11. Cremona, G., Higenbottam, T.W., Mayoral, V., Alexander, G., Demoncheaux, E., Borland, C., Roe, J., Jones, G.J.: Elevated exhaled nitric oxide in patients with hepatopulmonary syndrome. Eur. Respir. J. 1995; 8: 1883–1885

    Article  CAS  PubMed  Google Scholar 

  12. De, B.K., Sen, S., Biswas, P.K., Sanyal, R., Majumdar, D., Biswas, J.: Hepatopulmonary syndrome in inferior vena cava obstruction responding to cavoplasty. Gastroenterology 2000; 118: 192–196

    Article  CAS  PubMed  Google Scholar 

  13. De, B.K., Sen, S., Biswas, P.K., Mandral, S.K., Das, D., Das, U., Guru, S., Bandyopadhyay, K.: Occurrence of hepatopulmonary syndrome in Budd-Chiari syndrome and the role of venous decompression. Gastroenterology 2002; 122: 897–903

    Article  PubMed  Google Scholar 

  14. Dickinson, C.J.: The aetiology of clubbing and hypertrophic osteoarthropathy. Eur. J. Clin. Invest. 1993; 23: 330–338

    CAS  PubMed  Google Scholar 

  15. Eriksson, L.S., Söderman, C., Ericzon, B.-G., Eleborg, L., Wahren, J., Hedenstierna, G.: Normalization of ventilation perfusion relationship after liver transplantation in patients with decompensated cirrhosis: evidence for an hepatopulmonary syndrome. Hepatology 1990; 12: 1350–1357

    CAS  PubMed  Google Scholar 

  16. Fallon, M.B., Abrams, G.A., Luo, B., Hou, Z., Dai, J.: The role of endothelial nitric oxide synthase in the pathogenesis of a rat model of hepatopulmonary syndrome. Gastroenterology 1997; 113: 606–614

    Article  CAS  PubMed  Google Scholar 

  17. Fiel, M.I., Schiaro, T.D., Suriawinata, A., Emre, S.: Portal hypertension and hepatopulmonary syndrome in a middle-aged man with hepatitis B infection. Semin. Liver Dis. 2000; 20: 391–395

    Article  CAS  PubMed  Google Scholar 

  18. Flückiger, M.: Vorkommen von trommelschlägelförmigen Fingerendphalangen ohne chronische Veränderungen an den Lungen oder am Herzen. Wien. Med. Wschr. 1884; 34: 1457–1458

    Google Scholar 

  19. Folwaczny, C., Weber, M., Schreiner, J., Loeschke, K.: Zyanose und Uhrglasnägel bei chronischer Leberkrankheit. Internist 1994; 35:1066–1068

    CAS  PubMed  Google Scholar 

  20. Giniès, J.L., Couetil, J.P., Houssin, D., Guillemain, R., Champion, G., Bernard, O.: Hepatopulmonary syndrome in a child with cystic fibrosis. J. Pediatr. Gastroenterol. Nutr. 1996; 23: 497–500

    PubMed  Google Scholar 

  21. Gupta, D., Vijaya, D.R., Gupta, R., Dhiman, R.K., Bhargava, M., Verma, D.M.J., Chawla, Y.K.: Prevalence of hepatopulmonary syndrome in cirrhosis and extrahepatic portal venous obstruction. Amer. J. Gastroenterol. 2001; 96: 3395–3399

    CAS  Google Scholar 

  22. Hannam, P.D., Sandokji, A.K.M., Machan, L.S., Erb, S.R., Champion, P., Buczkowski, A.K., Scudamore, C.H., Steinbrecher, U.P., Chung, S.W., Weiss, A.A., Yoshida, E.M.: Post-surgical shunt hepatopulmonary syndrome in a case of non-cirrhotic portal hypertension: lack of efficacy of shunt reversal. Eur. J. Gastroenterol. Hepatol. 1999; 11: 1425–1427

    CAS  PubMed  Google Scholar 

  23. Hermann, H.P., Geibel, A., Konstantinidis, S., Wollschläger, H.: Shuntdiagnostik bei hepatopulmonalem Syndrom. Intensivmed. Notfallmed. 1993; 30: 326–329

    Google Scholar 

  24. Hourani, J.M., Bellamy, P.E.B., Tashkin, D.P., Batra, P., Simmons, M.S.: Pulmonary dysfunction in advanced liver disease: frequent occurrence of an abnormal diffusing capacity. Amer. J. Med. 1991; 90: 693–700

    CAS  PubMed  Google Scholar 

  25. Irle, U., Ohlms, F.B.: Leberzirrhose mit intrapulmonalen arteriovenösen Mikroanastomosen. Schweiz. Rundsch. Med. 1968; 57: 1720–1722

    CAS  Google Scholar 

  26. Jeffrey, G.P., Prince, R.L., van der Schaaf, A.: Fatal intrapulmonary arteriovenous shunting in cirrhosis; diagnosis by radionuclide lung perfusion scan. Med. J. Aust. 1990; 152: 549–553

    CAS  PubMed  Google Scholar 

  27. Kaymakoglu, S., Kahraman, T., Kudat, H., Demir, K., Cakaloglu, Y., Adalet, I., Dincer, D., Besisik, F., Boztas, G., Sözen, A.B., Mungan, Z., Okten, A.: Hepatopulmonary syndrom in noncirrhotic portal hypertensive patients. Dig. Dis. Sci. 2003; 48: 556–560

    Article  CAS  PubMed  Google Scholar 

  28. Krowka, M.J., Cortese, D.A.: Hepatopulmonary syndrome — current concepts in diagnostic and therapeutic considerations. Chest 1994;105: 1528–1537

    CAS  PubMed  Google Scholar 

  29. Krowka, M.J., Porayko, M.K., Plevak, D.J., Pappas, S.C., Steers, J.L., Krom, R.A.F., Wiesner, R.H.: Hepatopulmonary syndrome with progressive hypoxemia as an indication for liver transplantation: case reports and literature review. Mayo Clin. Proc. 1997; 72: 44–53

    CAS  PubMed  Google Scholar 

  30. Lange, P.A., Stoller, J.K.: The hepatopulmonary syndrome. Effect of liver transplantation. Clin. Chest Med. 1996; 17: 115–123

    Article  CAS  PubMed  Google Scholar 

  31. Lasch, H.M., Fried, M.W., Zacks, S.L., Odell, P., Johnson, M.W., Gerber, D.A., Sandhu, F.S., Fair, J.H., Shrestha, R.: Use of transjugular intrahepatic portosystemic shunt as a bridge to liver transplantation in a patient with severe hepatopulmonary syndrome. Liver Transplant. 2001; 7: 147–149

    Article  CAS  Google Scholar 

  32. Lee, K.-N., Lee, H.-J., Shin, W.W., Webb, W.R.: Hypoxemia and liver cirrhosis (hepatopulmonary syndrome) in eight patients: comparison of the central and peripheral pulmonary vasculature. Radiology 1999;211: 549–553

    CAS  PubMed  Google Scholar 

  33. Lima, B.L.G., Franca, A.V.C., Pazin-Filho, A., Araujo, W.M., Martinez, J.A.B., Maciel, B.C., Simoes, M.V., Terra-Filho, J., Martinelli, A.L.C.: Frequency, clinical characteristics and respiratory parameters of hepatopulmonary syndrome. Mayo Clin. Proc. 2004; 79: 42–48

    PubMed  Google Scholar 

  34. Martinez, G.P., Barbera, J.A., Visa, J., Rimola, A., Pare, J.C., Roca, J., Navasa, M., Rodes, J., Rodriguez-Roisin, R.: Hepatopulmonary syndrome in candidates for liver transplantation. J. Hepatol. 2001; 34:651–657

    CAS  PubMed  Google Scholar 

  35. Martini, G.A., Hagemann, J.E.: Über Fingernagelveränderungen bei Lebercirrhose als Folge veränderter peripherer Durchblutung. Klin. Wschr. 1956; 34: 25–31

    Article  CAS  PubMed  Google Scholar 

  36. McAdams, H.P., Erasmus, J., Crockett, R., Mitchell, J., Godwin, J.D., McDermott, V.G.: The hepatopulmonary syndrome: radiologic findings in 10 patients. Amer. J. Roentgenol. 1996; 166: 1379–1385

    CAS  Google Scholar 

  37. Poterucha, J.J., Krowka, M.J., Dickson, E.R., Cortese, D.A., Stanson, A.W., Krom, R.A.: Failure of hepatopulmonary syndrome to resolve after liver transplantation and successful treatment with embolotherapy. Hepatology 1995; 21: 96–100

    Article  CAS  PubMed  Google Scholar 

  38. Regev, A., Yeshurun, M., Rodriguez, M., Sagie, A., Neff, G.W., Molina, E.G., Schiff, E.R.: Transient hepatopulmonary syndrome in a patient with acute hepatitis A. J. Viral Hepat. 2001; 8: 83–86

    Article  CAS  PubMed  Google Scholar 

  39. Riegler, J.L., Lang, K.A., Johnson, S.P., Westerman, J.H.: Transjugular intrahepatic portosystemic shunt improves oxygenation in hepatopulmonary syndrome. Gastroenterology 1995; 109: 978–983

    Article  CAS  PubMed  Google Scholar 

  40. Robin, E.D., Laman, D., Horn, B.R., Theodore, J.: Platypnea related to orthodeoxia caused by true vascular lung shunts. New Engl. J. Med. 1976; 294: 941–943

    CAS  PubMed  Google Scholar 

  41. Rolla, G., Bucca, C., Brussino, L.: Methylene blue in the hepatopulmonary syndrome. New Engl. J. Med. 1994; 331: 1098

    Article  CAS  PubMed  Google Scholar 

  42. Rutishauser, M., Egli, F., Wyler, F.: Juvenile Leberzirrhose mit multiplen arterio-venösen Aneurysmen der Lunge. Schweiz. Med. Wschr. 1972;102: 514–517

    CAS  PubMed  Google Scholar 

  43. Rydell, R., Hoffbauer, F.W.: Multiple pulmonary arteriovenous fistulas in juvenile cirrhosis. Amer. J. Med. 1956; 21: 450–460

    PubMed  Google Scholar 

  44. Schenk, P., Madl, C., Rezzaie-Majd, S., Lehr, St., Müller, C.: Methylene blue improves the hepatopulmonary syndrome. Ann. Intern. Med. 2000;133: 701–706

    CAS  PubMed  Google Scholar 

  45. Schenk, P., Schöniger-Hekele, M., Fuhrmann, V., Madl, C., Silberhumer, G., Müller, C.: Prognostic significance of the hepatopulmonary syndrome in patients with cirrhosis. Gastroenterology 2003; 125:1042–1052

    Article  PubMed  Google Scholar 

  46. Scott, V., Miro, A., Kang, Y., DeWolf, A., Bellary, S., Martin, M., Kramer, A., Selby, R., Doyle, H., Paradis, I., Starzl, T.E.: Reversibility of the hepatopulmonary syndrome by orthotopic liver transplantation. Transplant. Proc. 25 (1993), 1787–1788

    CAS  PubMed  Google Scholar 

  47. Selim, K.M., Akriviadis, E.A., Zuckerman, E., Chen, D., Reynolds, T.B.: Transjugular intrahepatic portosystemic shunt: a successful treatment for hepatopulmonary syndrome. Amer. J. Gastroenterol. 1998; 93:455–458

    CAS  Google Scholar 

  48. Shijo, H., Sasaki, H., Miyajima, Y., Okumura, M.: Prostaglandin F2α and indomethacin in hepatogenic pulmonary angiodysplasia: effects on pulmonary hemodynamics and gas exchange. Chest 1991; 100: 873–875

    CAS  PubMed  Google Scholar 

  49. Snell, A.M.: The effects of chronic disease of the liver on the composition and physicochemical properties of blood: changes in the serum proteins; reduction in the oxygen saturation of the arterial blood. Ann. Intern. Med. 1935; 9: 690–711

    Google Scholar 

  50. Stein, H., Stein, S.: Digital clubbing in cirrhosis of the liver. Lancet 1961/I: 999–1000

    Google Scholar 

  51. Vachiéry, F., MoraJ, R., Hadengue, A., Gadano, A., Soupison, T., Valla, D., Lebrec, D.: Hypoxemia in patients with cirrhosis: relationship with liver failure and hemodynamic alterations. J. Hepatol. 1997; 27:492–495

    PubMed  Google Scholar 

  52. Wagner, P.D.: Impairment of gas exchange in cirrhosis. Eur. Resp. J. 1995; 8: 1993–1995

    CAS  Google Scholar 

  53. Wettstein, M., Gerok, W., Häussinger, D.: Endotoxin-induced nitric oxide synthesis in the isolated perfused rat liver. Hepatology 1994; 19:641–647

    CAS  PubMed  Google Scholar 

  54. Whyte, M.K.B., Hughes, J.M.B., Peters, A.M., Ussow, W., Patel, S., Burroughs, A.K.: Analysis of intrapulmonary right to left shunt in the hepatopulmonary syndrome. J. Hepatol. 1998; 29: 85–93

    Article  CAS  PubMed  Google Scholar 

  55. Williams, A., Trewby, P., Williams, R., Reid, L.: Structural alterations to the pulmonary circulation in fulminant hepatic failure. Thorax 1979;34: 447–453

    CAS  PubMed  Google Scholar 

  56. Yao, E.H., Kong, B., Hsue, G., Zhou, A., Wang, H.: Pulmonary function changes in cirrhosis of the liver. Amer. J. Gastroenterol. 1987; 82:352–354

    CAS  Google Scholar 

  57. Zhang, J.L., Ling, Y.Q., Luo, B., Tang, L.P., Ryter, S.W., Stockard, C.R., Grizzle, W.E., Fallon, M.B.: Analysis of pulmonary heme oxygenase-1 and nitric oxide synthase alterations in experimental hepatopulmonary syndrome. Gastroenterology 2003; 125: 1441–1451

    Article  CAS  PubMed  Google Scholar 

Portopulmonary hypertension

  1. Bayraktar, Y., Tanaci, N., Egesel, T., Gököz, A., Balkanci, F.: Antiphospholipid syndrome presenting as portopulmonary hypertension. J. Clin. Gastroenterol. 2001; 32: 359–361

    Article  CAS  PubMed  Google Scholar 

  2. Colle, I., Moreau, R., Godinho, E., Belghiti, J., Ertori, F., Cohen-Solai, A., Mal, H., Bernuau, J., Marty, J., Lebrec, D., Valla, D., Durand, F.: Diagnosis of portopulmonary hypertension in candidates for liver transplantation: a prospective study. Hepatology 2003; 37: 401–409

    Article  PubMed  Google Scholar 

  3. Kähler, C.M., Graziadei, I., Wiedermann, C.J., Kneussl, M.P., Vogel, W.: Successful use of continuous intravenous prostacyclin in a patient with severe portopulmonary hypertension. Wien. Klin. Wschr. 2000; 112:637–640

    PubMed  Google Scholar 

  4. Krowka, M.J., Frantz, R.P., McGoon, M.D., Severson, C., Plevak, D.J., Wiesner, R.H.: Improvement in pulmonary hemodynamics during intravenous epoprostenol (prostacyclin): a study of 15 patients with moderate to severe portopulmonary hypertension. Hepatology 1999; 30:641–648

    Article  CAS  PubMed  Google Scholar 

  5. Krowka, M.J.: Hepatopulmonary hypertension and portopulmonary hypertension: distinctions and dilemmas. Hepatology 1997; 25:1282–1284

    Article  CAS  PubMed  Google Scholar 

  6. Kuo, P.C., Plotkin, J.S., Gaine, S., Schroeder, R.A., Rustgi, V.K., Rubin, L.R., Johnson, L.B.: Portopulmonary hypertension and the liver transplant candidate. Transplantation 1999; 67: 1087–1093

    CAS  PubMed  Google Scholar 

  7. Levy, M.T., Torzillo, P., Bookallil, M., Sheil, A.G.R., McCaughan, G.W.: Case report: Delayed resolution of severe pulmonary hypertension after isolated liver transplantation in a patient with cirrhosis. J. Gastroenterol. Hepatol. 1996; 11: 734–737

    CAS  PubMed  Google Scholar 

  8. Mantz, F., Craige, E.: Portal axis thrombosis with spontaneous portocaval shunt and resultant cor pulmonale. AMA Arch. Pathol. 1951; 52: 91–97

    PubMed  Google Scholar 

  9. Masaki, T.: The discovery of endothelins. Cardiovasc. Res. 1998; 39: 530–533

    Article  CAS  PubMed  Google Scholar 

  10. Rubin, L.J., Badesch, D.B., Barst, R.J., Galie, N., Black, C.M., Keogh, A., Pulido, T., Frost, A., Roux, S., Leconte, I., Landzberg, M., Simonneau, G.: Bosentan therapy for pulmonary arterial hypertension. New Engl. J. Med. 2002; 346: 896–903

    Article  CAS  PubMed  Google Scholar 

  11. Schraufnagel, D.E., Kay, J.M.: Structural and pathologic changes in the lung vasculature in chronic liver disease. Clin. Chest Med. 1996; 17:1–15

    Article  CAS  PubMed  Google Scholar 

  12. Starkel, P., Vera, A., Gunson, B., Mutimer, D.: Outcome of liver transplantation for patients with pulmonary hypertension. Liver Transplant. 2002; 8: 382–388

    Article  Google Scholar 

  13. Yang, Y.Y., Lin, H.C., Lee, W.C., Hou, M.C., Lee, F.Y., Chang, F.Y., Lee, S.D.: Portopulmonary hypertension: distinctive hemodynamic and clinical manifestations. J. Gastroenterol. 2001; 36: 181–186

    Article  CAS  PubMed  Google Scholar 

  14. Yokomori, H., Oda, M., Yasogawa, Y., Nishi, Y., Ogi, M., Takahashi, M., Ishii, H.: Enhanced expression of endothelin B receptor at protein and gene levels in human cirrhotic liver. J. Pathol. 2001; 159: 1353–1362

    CAS  Google Scholar 

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(2006). Hepatopulmonary syndrome. In: Hepatology Principles and Practice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-28977-1_18

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  • DOI: https://doi.org/10.1007/3-540-28977-1_18

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