Skip to main content
SpringerLink
Log in

Putting IGF-I Biology into a Clinical Perspective

  • Conference paper
Deciphering Growth

Part of the book series: Research and Perspectives in Endocrine Interactions ((RPEI))

  • 278 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aguiar-Oliveira MH, Gill MS, de A Barretto ES, Alcantara MR, Miraki-Moud F, Menezes CA, Souza AH, Martinelli CE, Pereira FA, Salvatori R, Levine MA, Shalet SM, Camacho-Hubner C, Clayton PE (1999) Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life. J Clin Endocrinol Metab 84:4118–126.

    Article  PubMed  CAS  Google Scholar 

  • Boquete HR, Sobrado PG, Fideleff HL, Sequera AM, Giaccio AV, Suarez MG, Ruibal GF, Miras M (2003) Evaluation of diagnostic accuracy of insulin-like growth factor (IGF)-I and IGF-binding protein-3 in growth hormone-deficient children and adults using ROC plot analysis. J Clin Endocrinol Metab 88:4702–4708.

    Article  PubMed  CAS  Google Scholar 

  • Chan JM, Stampfer MJ, Giovannucci E, Gann PH, Ma J, Wilkinson P, Hennekens CH, Pollak M (1998) Plasma insulin-like growth factor-1 and prostate cancer risk: a prospective study. Science 279:563–566.

    Article  PubMed  CAS  Google Scholar 

  • Clayton PE (1999) The role of insulin-like growth factors and other biochemical parameters in the diagnosis of growth hormone deficiency. In: Ranke MB, Wilton P (eds) Growth hormone therapy-ten years of KIGS 1987–1997. J.A. Barth Verlag, Heidelberg, pp 53–64.

    Google Scholar 

  • Cohen P, Bright GM, Rogol AD, Kappelgaard AM, Rosenfeld RG, American Norditropin Clinical Trials Group (2002) Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: implications for efficacy and safety. J Clin Endocrinol Metab 87:90–98.

    Article  PubMed  CAS  Google Scholar 

  • Das U, Whatmore AJ, Khosravi J, Wales JK, Butler G, Kibirige MS, Diamandi A, Jones J, Patel L, Hall CM, Price DA, Clayton PE (2003) IGF-I and IGF-binding protein-3 measurements on filter paper blood spots in children and adolescents on GH treatment: use in monitoring and as markers of growth performance. Eur J Endocrinol 149:179–185.

    Article  PubMed  CAS  Google Scholar 

  • Drake WM, Coyte D, Camacho-Hubner C, Jivanji NM, Kaltsas G, Wood DF, Trainer PJ, Grossman AB, Besser GM, Monson JP (1998) Optimizing growth hormone replacement therapy by dose titration in hypopituitary adults. J Clin Endocrinol Metab 83:3913–3919.

    PubMed  CAS  Google Scholar 

  • Hankinson SE, Willett WC, Colditz GA, Hunter DJ, Michaud DS, Deroo B, Rosner B, Speizer FE, Pollak M (1998) Circulating concentrations of insulin-like growth factor-1 and risk of breast cancer. Lancet 351:1393–1396.

    Article  PubMed  CAS  Google Scholar 

  • Juul A, Bernasconi S, Clayton PE, Kiess W, DeMuinck-Keizer Schrama S, Drugs and Therapeutics Committee of the European Society for Paediatric Endocrinology (ESPE) (2002) European audit of current practice in diagnosis and treatment of childhood growth hormone deficiency. Horm Res 58:233–241.

    Article  PubMed  CAS  Google Scholar 

  • Kuo YH, Chen TT (2002) Novel activities of pro-IGF-I E peptides: regulation of morphological differentiation and anchorage-independent growth in human neuroblastoma cells. Exp Cell Res 280:75–89.

    Article  PubMed  CAS  Google Scholar 

  • Lanes R, Jakubowicz S (2002) Is insulin-like growth factor-1 monitoring useful in assessing the response to growth hormone of growth hormone-deficient children? J Pediatr 141:606–610.

    PubMed  CAS  Google Scholar 

  • Lowe WL Jr, Lasky SR, LeRoith D, Roberts CT Jr. (1988) Distribution and regulation of rat insulin-like growth factor I messenger ribonucleic acids encoding alternative carboxyterminal E-peptides: evidence for differential processing and regulation in liver. Mol Endocrinol 2:528–535.

    Article  PubMed  CAS  Google Scholar 

  • Musaro A, Giacinti C, Borsellino G, Dobrowolny G, Pelosi L, Cairns L, Ottolenghi S, Cossu G, Bernardi G, Battistini L, Molinaro M, Rosenthal N (2004) Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1. Proc Natl Acad Sci USA 101:1206–1210.

    Article  PubMed  CAS  Google Scholar 

  • O’sullivan DC, Szestak TA, Pell JM (2002) Regulation of IGF-I mRNA by GH: putative functions for class 1 and 2 message. Am J Physiol Endocrinol Metab 283:E251–258.

    PubMed  CAS  Google Scholar 

  • Petridou E, Dessypros N, Spanos E, Mantzoros C, Skalkidou A, Kalmanti M, Koliouskas D, Kosmidis H, Panagiotou JP, Piperopoulou F, Tzortzatou F, Trichopoulos D (1999) Insulin-like growth factor-1 and binding protein-3 in relation to childhood leukemia. Int J Cancer 80:494–496.

    Article  PubMed  CAS  Google Scholar 

  • Ranke MB, Schweizer R, Elmlinger MW, Weber K, Binder G, Schwarze CP, Wollmann HA (2001) Relevance of IGF-I, IGFBP-3, and IGFBP-2 measurements during GH treatment of GH-deficient and non-GH-deficient children and adolescents. Horm Res 55:115–124.

    PubMed  CAS  Google Scholar 

  • Report of a Workshop (2000) Consensus guidelines for the diagnosis and treatment of GH deficiency in childhood and adolescence: Summary statement of the GH Research Society on child and adolescent GH deficiency. J Clin Endocrinol Metab 85: 3990–3993.

    Google Scholar 

  • Report of a Workshop (2001) Critical evaluation of the safety of recombinant human growth hormone administration: Statement from the Growth Hormone Research Society. J Clin Endocrinol Metab 86:1868–1870.

    Google Scholar 

  • Rosenfeld RG (1997) Is growth hormone deficiency a viable diagnosis? J Clin Endocrinol Metab. 82:349–351.

    Article  PubMed  CAS  Google Scholar 

  • Swerdlow AJ, Higgins CD, Adlard P, Preece MA (2002) Risk of cancer in patients treated with human pituitary growth hormone in the UK, 1959–85: a cohort study. Lancet 360:273–277.

    Article  PubMed  CAS  Google Scholar 

  • Tillmann V, Patel L, Gill MS, Whatmore AJ, Price DA, Kibirige MS, Wales JK, Clayton PE (2000) Monitoring serum insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3), IGF-I/IGFBP-3 molar ratio and leptin during growth hormone treatment for disordered growth. Clin Endocrinol (Oxf) 53:329–336.

    Article  CAS  Google Scholar 

  • van Pareren YK, de Muinck Keizer-Schrama SM, Stijnen T, Sas TC, Jansen M, Otten BJ, Hoorweg-Nijman JJ, Vulsma T, Stokvis-Brantsma WH, Rouwe CW, Reeser HM, Gerver WJ, Gosen JJ, Rongen-Westerlaken C, Drop SL (2003a) Final height in girls with Turner syndrome after long-term growth hormone treatment in three dosages and low dose estrogens. J Clin Endocrinol Metab 88:1119–1125.

    PubMed  Google Scholar 

  • Van Pareren Y, Mulder P, Houdijk M, Jansen M, Reeser M, Hokken-Koelega A (2003b) Adult height after long-term, continuous growth hormone (GH) treatment in short children born small for gestational age: results of a randomized, double-blind, dose-response GH trial. J Clin Endocrinol Metab 88:3584–3590.

    PubMed  Google Scholar 

  • Wyatt D (2004) Lessons from the national cooperative growth study. Eur J Endocrinol 151Suppl 1:S55–59.

    PubMed  CAS  Google Scholar 

  • Yu H, Spitz MR, Mistry J, Gu J, Hong WK, Wu X (1999) Plasma levels of insulin-like growth factor-l and lung cancer risk: a case-control analysis. J Natl Cancer Inst 91:151–156.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Academic of Child Health, Division of Human Development & Reproductive Health, The Medical School, University of Manchester, Manchester, England

    P.E. Clayton, U. Das & A.J. Whatmore

Authors
  1. P.E. Clayton
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. U. Das
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A.J. Whatmore
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Groupe Hospitalier Cochin-Saint Vincent de Paul-La-Roche Guyon, Hôpital Saint Vincent de Paul INSERM U.561 — Service d’Endocrinologie Pédiatrique, 74 à 82, Av Denfert Rochereau, 75674, Paris, France

    Jean-Claude Carel M.D.

  2. Inserm U584 Faculté de Médecine Necker Enfants Malades, 156, Rue de Vaugirard, 75730, Paris, France

    Paul A. Kelly Ph.D.

  3. Fondation IPSEN Pour la Recherche Thérapeutique, 24, rue Erlanger, 75781, Paris, France

    Yves Christen Ph.D.

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Clayton, P., Das, U., Whatmore, A. (2005). Putting IGF-I Biology into a Clinical Perspective. In: Carel, JC., Kelly, P.A., Christen, Y. (eds) Deciphering Growth. Research and Perspectives in Endocrine Interactions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-28902-X_9

Download citation

Publish with us

Policies and ethics

Search

Navigation