Conclusions
Brain MRS provides chemical-pathological information that has the potential to improve both diagnostic classification and management of patients with metabolic disorders affecting the brain white matter. Metabolic indices provided by proton MRS and MRSI could be sensitive indicators of early neurological involvement, relevant to patients’ clinical status. A more extensive use of a combination of MR modalities including volumetric MRI, MRS and other nonconventional MR techniques might yield a more complete description of the dynamics responsible for pathological changes in this heterogeneous group of disorders and allow a more accurate evaluation of disease progression and response to therapy. A wider use of proton MRS techniques should be encouraged in clinical studies of patients with metabolic disorders.
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De Stefano, N., Mortilla, M. (2005). Proton MR Spectroscopy in Metabolic Disorders of the Central Nervous System. In: Filippi, M., De Stefano, N., Dousset, V., McGowan, J.C. (eds) MR Imaging in White Matter Diseases of the Brain and Spinal Cord. Medical Radiology Diagnostic Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27644-0_13
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