9.5 Summary
The convergent pathobiologic model of Parkinson’s disease stipulates that disparate insults initiate a disease process that obligately share a common pathway leading to cell death. A combinatorial treatment which targets various steps in this pathway is likely to be the most successful therapeutic strategy. As advances are made in the field of neuroimaging and pharmacogenomics, early detection of sporadic PD will become a reality. Early intervention will likely sparemore dopaminergic neurons and extend the quality of life for the patient. Continued advancements in the fields of pharmacology, neurosurgery, and gene therapy will strengthen the armamentarium available for the treatment of PD patients.
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Maguire-Zeiss, K.A., Federoff, H.J. (2005). Novel Gene Therapeutic Strategies for Neurodegenerative Diseases. In: Perez, H.D., Mitrovic, B., Baron Van Evercooren, A. (eds) Opportunities and Challenges of the Therapies Targeting CNS Regeneration. Ernst Schering Research Foundation Workshop, vol 53. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-27626-2_9
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