Skip to main content

Endotoxinbindende Proteine, Antiendotoxinantikörper

  • Chapter
Sepsis und MODS
  • 722 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 4.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Aliprantis AO, Yang RB, Weiss DS, Godowski P, Zychlinsky A (2000) The apoptotic pathway activated by toll-like receptor 2. EMBO J 19: 3325–3336

    Article  PubMed  CAS  Google Scholar 

  2. Alpert G, Baldwin G, Thompson C et al. (1992) Limulus antipolysaccharide factor protects rabbits from meningococcal endotoxin shock. Infect Dis 165: 494–500

    CAS  Google Scholar 

  3. Bazil V, Strominger JL (1991) Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes. J Immunol 147: 1567–1574

    PubMed  CAS  Google Scholar 

  4. Brade L, Kosma P, Appelmelk BJ, Paulsen H, Brade H (1987) Use of synthetic antigens to determine the epitope specificities of monoclonal antibodies against the 3-deoxy-D-manno-octulosonate region of bacterial lipopolysaccharide. Infect Immun 55: 462–466

    PubMed  CAS  Google Scholar 

  5. Bunnell E, Lynn M, Parillo JE, Habet K, Friedhoff LT, Rogers SL (1995) Effect of E5531 on systemic responses to endotoxin in healthy volunteers. Crit Care Med 23: A147

    Google Scholar 

  6. Bunnell E, Neumann A, Lynn M, Friedhoff LT, Rogers SL, Habet K, Parrillo JE (1995) E 5531, an endotoxin antagonist, blocks the hyperdynamic and depressant cardiovascular effects of endotoxin in healthy subjects. Crit Care Med 23: A151

    Google Scholar 

  7. Christ WJ, Asano O, Robidoux ALC et al. (1995) E5531, a pure endotoxin antagonist of high potency. Science 268: 80–83

    PubMed  CAS  Google Scholar 

  8. Cryz SJ, Wedgwood J, Lang AB, Ruedeberg A, Fürer E, Schaad UB (1994) Immunization of noncolonized cystic fibrosis patients against Pseudomonas aeruginosa. J Infect Dis 169: 1159–1162

    PubMed  Google Scholar 

  9. Desch CE, OHara P, Harlan J (1989) Anti-lipopolysaccharide factor from T tridentatus inhibits lipopolysaccharide activation of cultured human endothelial cells. Infect Immun 57: 1612–1614

    PubMed  CAS  Google Scholar 

  10. Di Padua FE, Brade H, Barclay R et al. (1993) A broadly cross-protective monoclonal antibody binding to E. coli and Salmonella lipopolysaccharide. Infect Immun 61: 3863–3872

    Google Scholar 

  11. Fisher JC, Marra MN, Palardy JE, Marchbanks CR, Scott R, Opal SM (1994) Human neutrophil bactericidal/permeability-increasing protein reduces mortality rate from endotoxin challenge: A placebo-controlled study. Crit Care Med 22: 553–558

    PubMed  Google Scholar 

  12. Fletcher M, McKenna TM, Quance JL, Wainwright NR, Williams TJ (1993) Lipopolysaccharide detoxification by endotoxin neutralizing protein. J Surg Res 55: 147–154

    Article  PubMed  CAS  Google Scholar 

  13. Garcia C, Saladino R, Thompson C et al. (1994) Effect of recombinant endotoxin-neutralizing protein on endotoxin shock in rabbits. Crit Care Med 22: 1211–1218

    PubMed  CAS  Google Scholar 

  14. Garcia C, Thompson C, Hammer B et al. (1994) Efficacy of a recombinant endotoxin neutralizing protein in rabbits with Escherichia coli sepsis. Circ Shock 42: 104–110

    PubMed  Google Scholar 

  15. Gazzano-Santoro H, Parent JB, Grinna L et al. (1992) High affinity binding of the bactericidal/permeability increasing protein and a recombinant amino terminal fragment to the Lipid A region of lipopolysaccharide. Infect Immun 60: 4754–4761

    PubMed  CAS  Google Scholar 

  16. Gazzano-Santoro H, Meszaros K, Birr C et al. (1994) Competition between rBPI23, a recombinant fragment of bactericidal/ permeability-increasing protein, and lipopolysaccharide (LPS)-binding protein for binding to LPS and gram-negative bacteria. Infect Immun 62: 1184–1191

    Google Scholar 

  17. Giroir BP, Quint PA, Barton P et al. (1997) Preliminary evaluation of recombinant amino-terminal fragment of human bactericidal/permeability-increasing protein in children with severe meningococcal sepsis. Lancet 350: 1439–1443

    Article  PubMed  CAS  Google Scholar 

  18. Grunwald U, Krüger C, Schütt C (1993) Endotoxin-neutralizing capacity of soluble CD14 is a highly conserved specific function. Circ Shock 39: 220–225

    PubMed  CAS  Google Scholar 

  19. Hoess A, Watson S, Siber GR, Liddington R (1993) Crystal structure of an endotoxin-neutralizing protein from horseshoe crab, Limulus anti-LPS factor, at 1.5 Å resolution. EMBO J 12: 3351–3356

    PubMed  CAS  Google Scholar 

  20. Imler JL, Hoffmann JA (2001) Toll receptors in innate immunity. Trends Cell Biol 11: 304–311

    Article  PubMed  CAS  Google Scholar 

  21. Johnson KJ, Ward P, Goralnick BS, Osborn MJ (1977) Isolation from human serum of an inactivator of bacterial lipopolysaccharide. Am J Pathol 88: 559–574

    PubMed  CAS  Google Scholar 

  22. Krüger C, Schütt C, Obertacke U et al. (1991) Serum CD14 levels in polytraumatized and severely burned patients. Clin Exp Immunol 85: 297–301

    PubMed  Google Scholar 

  23. Kuppermann N, Nelson D, Saladino R et al. (1994) A comparison of a recombinant endotoxin neutralizing protein with a human monoclonal antibody to endotoxin for the treatment of E. coli sepsis in rats. J Infect Dis 170: 630–635

    PubMed  CAS  Google Scholar 

  24. Levin M, Quint PA, Goldstein B et al. (2000) Recombinant bactericidal/permeability-increasing protein (rBPI) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial. Lancet 356: 961–967

    PubMed  CAS  Google Scholar 

  25. Loppnow H, Libby P (1989) Adult human vascular endothelial cells express the IL-6 gene differentially in response to LPS or IL-1. Cell Immunol 122: 493–503

    Article  PubMed  CAS  Google Scholar 

  26. Loppnow H, Libby P (1992) Functional significance of human vascular smooth muscle cell-derived interleukin 1 in paracrine and autocrine regulation pathways. Exp Ceil Res 198: 283–290

    CAS  Google Scholar 

  27. Loppnow H, Rietschel ET, Brade H et al. (1993) Lipid A precursor Ia (compound 406) and Rhodobacter capsulatus lipopolysaccharide: potent endotoxin antagonists in the human system in vitro. In: Levin J, Alving CR, Munford RS, Stütz PL (eds) Bacterial endotoxin: Recognition and effector mechanisms. Elsevier, New York, pp 337–348

    Google Scholar 

  28. Marra MN, Wilde CG, Snable JL et al. (1990) Bactericidal/permeability-increasing protein has endotoxin neutralizing activity. J Immunol 144: 662–666

    PubMed  CAS  Google Scholar 

  29. Marra biN, Wilde CG, Collins MS, Snable JL, Thornton MB, Scott RW (1992) The role of bactericidal/permeability-increasing protein as a natural inhibitor of bacterial endotoxins. J Immunol 148: 532–537

    PubMed  CAS  Google Scholar 

  30. Marra MN, Thornton MB, Snable JL, Wilde CG, Scott RW (1994) Endotoxin-binding and-neutralizing properties of recombinant bactericidal/permeability increasing protein and monoclonal antibodies HA-1 A and E5. Crit Care Med 22: 559–565

    PubMed  CAS  Google Scholar 

  31. Medvedev AE, Kopydlowski KM, Vogel SN (2000) Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: Dysregulation of cytokine, chemokine and toll-like receptor 2 and 4 gene expression. J Immunol 164: 5564–5574

    PubMed  CAS  Google Scholar 

  32. Medzhitov R, Preston-Hurlburt P, Janeway CA (1997) A human homologue of the drosophila toll protein signals activation of adaptive immunity. Nature 388: 394–397

    PubMed  CAS  Google Scholar 

  33. Morita TS, Ohtsubo T, Nakamura T et al. (1985) Isolation and biological activities of Limulus anticoagulant (anti-lipopolysaccharide factor) which interacts with lipopolysaccharide (LPS ). J Biochem 97: 1611–1620

    PubMed  CAS  Google Scholar 

  34. Muta T, Miyata T, Tukunaga F, Nakamura T, Iwanaga S (1987) Primary structure of anti-lipopolysaccharide factor from American horseshoe crab, Limulus polyphemus. J Biochem 101: 1321–1330

    PubMed  CAS  Google Scholar 

  35. Nathan CF (1987) Secretory products of macrophages. J Clin Invect 79: 319–324

    CAS  Google Scholar 

  36. Nomura F, Akashi S, Sakao Y et al. (2000) Endotoxin tolerance in mouse peritoneal macrophages correlates with downregulation of surface toll-like receptor 4 expression. J Immunol 164: 3476–3479

    PubMed  CAS  Google Scholar 

  37. Ooi CE, Weiss J, Doerfler ME, Elsbach P (1991) Endotoxin-neutralizing properties of the 25 kD N-terminal fragment and a newly isolated 30 kD C-terminal fragment of the 55-60 kD bactericidal/permeability-increasing protein of human neutrophils. J Exp Med 174: 649–655

    Article  PubMed  CAS  Google Scholar 

  38. Pugin J, Schürer-Maly CC, Leturcq D, Moriarty A, Ulevitch RJ, Tobias PS (1993) Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc Natl Acad Sci USA 90: 2744–2748

    PubMed  CAS  Google Scholar 

  39. Randow F, Syrbe U, Meisel C et al. (1995) Mechanism of endotoxin desensitization: involvement of interleukin 10 and transforming growth factor beta. J Exp Med 181: 1887–1892

    Article  PubMed  CAS  Google Scholar 

  40. Rietschel ET, Kirikae T, Feist W et al. (1991) Molecular aspects of the chemistry and biology of endotoxin. In: Sies H, Flohe L, Zimmer G (eds) 42th Colloquium Mosbach 1991. Molecular aspects of inflammation. Springer, Berlin Heidelberg New York Tokio, pp 207–231

    Google Scholar 

  41. Rietschel ET, Brade H (1992) Bacterial endotoxins. Sci Am 267: 54–61

    Article  PubMed  CAS  Google Scholar 

  42. Saladino R, Garcia CT, Thompson C et al. (1991) Assessment of intravenous endotoxin neutralizing protein in a rabbit model. Pediatr Res 29: 33 A

    Google Scholar 

  43. Sato S, Nomura F, Kawai T, et al. (2000) Synergy and cross-tolerance between toll-like receptor (TLR) 2-and TLR-4 mediated signaling pathways. J Immunol 165: 7096–7101

    PubMed  CAS  Google Scholar 

  44. Schletter J, Brade H, Krüger C, Loppnow H, Rietschel ET, Flad HD, ULmer AJ (1994) Binding of lipololysaccharide to an 80 kDa membrane protein of human cells is mediated by serum factors. Immunobiology 191: 273

    Google Scholar 

  45. Schumann RR, Leong SR, Flaggs GW, Gray PW, Wright SD, Mathison JC, Tobias PS, Ulevitch RJ (1990) Structure and function of lipopolysaccharide binding protein. Science 249: 1429–1431

    PubMed  CAS  Google Scholar 

  46. Schumann RR, Lamping N, Kirschning C, Knopf HP, Hoess A, Herrmann F (1994) Lipopolysaccharide binding protein: Its role and therapeutic potential in inflammation and sepsis. Biochem Soc Transact 22; 80–83

    CAS  Google Scholar 

  47. Schumann RR, Rietschel ET, Loppnow H (1995) The role of CD14 and lipopolysaccharide binding protein (LBP) in the activation of different cell types by endotoxin. Med Microbiol Immunol

    Google Scholar 

  48. Schütt C, Schilling T, Krüger C (1991) sCD14 prevents endotoxin induced oxidative burst response of human monocytes. Allerg Immunol 37: 159–164

    Google Scholar 

  49. Schütt C, Schilling T, Grunwald U, Schönfeld W, Krüger C (1992) Endotoxin-neutralizing capacity of soluble CD14. Res Immunol 143: 71–78

    PubMed  Google Scholar 

  50. Seydel U, Brandenburg K, Rietschel ET (1994) A case for an endotoxic conformation. In: Levin J et al. (eds) Bacterial endotoxins: Basic science to anti-sepsis strategies. Wiley-Liss, New York, pp 17–30

    Google Scholar 

  51. Stenger S, Engele M, Bölcskei PL, Röllinghoff PM, Wagner M (2001) Induction of direct antimicrobial activity through mammalian toll-like receptors. Science 291: 1544–1547

    PubMed  Google Scholar 

  52. Tanaka S, Nakamura T, Morita T, Iwanaga S (1982) Limulus anti-lipopolysaccharide factor: An anticoagulant which inhibits the endotoxin-mediated activation of Limulus coagulation system. Biochem Biophys Res Commun 105: 717–723

    Article  PubMed  CAS  Google Scholar 

  53. Tapping RI, Akashi S, Miyake K, Godowski GJ, Tobias PS (2000) Toll-like receptor 4, but not toll-like receptor 2, is a signaling receptor for Escherichia and Salmonella lipopolysaccharides. J Immunol 165: 5780–5787

    PubMed  CAS  Google Scholar 

  54. Theofan G, Horwitz AH, Williams ER et al. (1994) An aminoterminal fragment of human lipopolysaccharide-binding protein retains Lipid A binding but not CD14-stimulatory activity. J Immunol 152: 3623–3629

    PubMed  CAS  Google Scholar 

  55. Tobias PS, Mathison JC, Ulevitch RJ (1988) A family of lipopolysaccharide binding proteins involved in responses to gram-negative sepsis. J Biol Chem 263: 13479–13481

    PubMed  CAS  Google Scholar 

  56. Wainwright NR, Müller RJ, Paus E et al. (1990) Endotoxin binding and neutralizing activity by a protein from Limulus polyphemus. In: Novotny A (ed) Cellular and molecular aspects af endotoxin reaction. Elsevier, New York, pp. 315–325

    Google Scholar 

  57. Warren HS, Glennon ML, Wainwright N et al. (1992) Binding and neutralization of endotoxin by limulus antilipopolysaccharide factor. Infect Immun 60: 2506–2513

    PubMed  CAS  Google Scholar 

  58. Weinstein SL, Gold MR, DeFranco AL (1991) Bacterial lipopolysaccharide stimulation protein tyrosine phosporylation in macrophages. Proc Natl Acad Sci USA 88: 4148–4152

    PubMed  CAS  Google Scholar 

  59. Weiss J, Elsbach P, Olsson I et al. (1978) Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leucocytes. J Biol Chem 253: 2664–2672

    PubMed  CAS  Google Scholar 

  60. Wurfel M, Kunitake ST, Lichenstein H, Kane JP, Wright SD (1994) Lipopolysaccharide (LPS)-binding protein is car-ried on lipoproteins and acts as a cofactor in the neutralization of LPS. J Exp Med 180: 1025–1035

    Article  PubMed  CAS  Google Scholar 

  61. Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison LC (1990) CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding proteins. Science 249: 1431–1433

    PubMed  CAS  Google Scholar 

  62. Zähringer U, Lindner B, Rietschel ET (1994) Molecular structure of Lipid A, the endotoxic center of bacterial lipopolysaccharides. Adv Carbohydr Chem Biochem 50: 211–276

    PubMed  Google Scholar 

  63. Ziegler-Heitbrock HWL, Ulevitch RJ (1993) CD14: Cell surface receptor and differentiation marker. Immunol Today 14: 121–125

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer Medizin Verlag Heidelberg

About this chapter

Cite this chapter

Zabel, P. (2005). Endotoxinbindende Proteine, Antiendotoxinantikörper. In: Werdan, K., Schuster, HP., Müller-Werdan, U. (eds) Sepsis und MODS. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26587-2_8

Download citation

  • DOI: https://doi.org/10.1007/3-540-26587-2_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-00004-4

  • Online ISBN: 978-3-540-26587-0

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics