Skip to main content
SpringerLink
Log in

Pharmacogenetics

  • Chapter
  • First Online:
Reviews of Physiology, Biochemistry and Pharmacology, Volume 83

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 83))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Agarwal, D.P., Srivastava, L.M., Goedde, H.W.: A note on suxamethonium sensitivity and serum cholinesterase variants. Hum. Genet. 32, 85–88 (1976)

    Google Scholar 

  • Akiskal, H.S., McKinney, W.T.: Overview of recent research in depression. Arch. Gen. Psychiat. 32, 285–305 (1975)

    Google Scholar 

  • Alexanderson, B.: Pharmacokinetics of desmethylimipramine and nortriptyline in man after single and multiple oral doses — a cross-over study. Eur. J. Clin. Pharmacol. 5, 1–10 (1972)

    Google Scholar 

  • Alexanderson, B., Borga, O.: Interindividual differences in plasma protein binding of nortriptyline in man — a twin study. Eur. J. Clin. Pharmacol. 4, 196–200 (1972)

    Google Scholar 

  • Alexanderson, B., Evans, D.A.P., Sjöqvist, F.: Steady-state plasma levels of nortriptyline in twins: influence of genetic factors and drug therapy. Brit. Med. J. 4, 764–768 (1969)

    Google Scholar 

  • Altland, K.: Pseudocholinesterasen. In: Humangenetik. Ein kurzes Handbuch in fünf Bänden. Becker, P.E. (ed.). Stuttgart: Thieme 1975, Vol. I/3, p. 327–351

    Google Scholar 

  • Altland, K., Goedde, H.W.: Heterogeneity in the silent gene phenotype of pseudocholinesterase of human serum. Biochem. Genet. 4, 321–338 (1970)

    Google Scholar 

  • Andreasen, P.B., Frøland, A., Skovsted, L., Andersen, S.A., Hauge, M.: Diphenylhydantoin half-life in man and its inhibition by phenylbutazone: the role of genetic factors. Acta Med. Scand. 193, 561–564 (1973)

    Google Scholar 

  • Angst, J.: A clinical analysis of the effects of tofranil in depression. Longitudinal and follow-up studies. Treatment of blood-relations. Psychopharmacologia 2, 381–407 (1961)

    Google Scholar 

  • Angst, J.: Antidepressiver Effekt und genetische Faktoren. Arzneim. Forsch. 14, 496–500 (1964)

    Google Scholar 

  • Armaly, M.F.: Genetic factors related to glaucoma. Ann. N.Y. Acad. Sci. 151, 861–875 (1968)

    Google Scholar 

  • Asberg, M.: Plasma nortriptyline levels — relationship to clinical effects. Clin. Pharmacol. Ther. 16, 215–229 (1974)

    Google Scholar 

  • Asberg, M., Evans, D.A.P., Sjöqvist, F.: Genetic control of nortriptyline plasma levels in man: a study of the relatives of propositi with high plasma concentration. J. Med. Genet. 8, 129–135 (1971)

    Google Scholar 

  • Asmussen, E., Hald, J., Larsen, V.: The pharmacological action of acetaldehyde on the human organism. Acta Pharmacol. 4, 311–320 (1948)

    Google Scholar 

  • Atlas, S.A., Vesell, E.S., Nebert, D.W.: Genetic control of interindividual variations in the inducibility of aryl hydrocarbon hydroxylase in cultured human lymphocytes. Cancer Res. 36, 4619–4630 (1976)

    Google Scholar 

  • Baker, E.L., Smrek, A., Kimbrough, R.D., Hudgins, M., Landrigan, P.J., Liddle, J.A.: Hereditary cholinesterase deficiency: a report of a family with two rare genotypes. Clin. Genet. 12, 134–138 (1977)

    Google Scholar 

  • Bennion, L.J., Li, T.-K.: Alcohol metabolism in American Indians and Whites. N. Engl. J. Med. 294, 9–13 (1976)

    Google Scholar 

  • Bente, D.: Differentielle und generelle Wirkungen psychotroper Pharmaka auf das menschliche EEG. In: Psychopharmacology, Sexual Disorders and Drug Abuse. Ban, T.A., et al. (eds.). Amsterdam: North-Holland 1973, p. 149–156

    Google Scholar 

  • Beutler, E.: Glucose 6-phosphate dehydrogenase deficiency. In: The Metabolic Basis of Inherited Disease. Stanbury, J.B., Wyngaarden, J.B., Fredrickson, D.S. (eds.). New York: McGraw-Hill, p. 1358–1388

    Google Scholar 

  • Bönicke, R., Lisboa, B.P.: Über die Erbbedingtheit der intraindividuellen Konstanz der Isoniazidausscheidung. Naturwissenschaften 44, 314 (1957)

    Google Scholar 

  • Brewer, G.J.: Human ecology, an expanding role for the human geneticist. Am. J. Hum. Genet. 23, 92–94 (1971)

    Google Scholar 

  • Campbell, W., Tilstone, W.J., Lawson, D.H., Hutton, I., Lawrie, T.D.V.: Acetylator phenotype and the clinical pharmacology of slow-release procainamide. Br. J. Clin. Pharmacol. 3, 1023–1026 (1976)

    Google Scholar 

  • Carlson, H.B., Anthony, E.M., Russell, W.F., Middlebrook, G.: Prophylaxis of isoniazid neuropathy with pyridoxine. N. Engl. J. Med. 255, 118–122 (1956)

    Google Scholar 

  • Cascorbi, H.F., Vesell, E.S., Blake, D.A., Helrich, M.: Genetic and environmental influence on halothane metabolism in twins. Clin. Pharmacol. Ther. 12, 50–55 (1971)

    Google Scholar 

  • Casper, R.C., Pandey, G., Gosenfeld, L., Davis, J.M.: Intracellular lithium and clinical response. Lancet 1976/II, 418–419

    Google Scholar 

  • Caspers, H.: Die Beeinflussung der corticalen Krampferregbarkeit durch das aufsteigende Reticulärsystem des Hirnstammes. I. Reizwirkungen. Z. Ges. Exp. Med. 129, 128–144 (1957)

    Google Scholar 

  • Caspers, H.: Die Beeinflussung der corticalen Krampferregbarkeit durch das aufsteigende Reticulärsystem des Hirnstammes. II. Narkosewirkungen. Z. Ges. Exp. Med. 129, 582–600 (1958)

    Google Scholar 

  • Claridge, G., Canter, S., Hume, W.J.: Personality Differences and Biological Variations. A Study of Twins. Oxford: Pergamon Press 1973

    Google Scholar 

  • Cunningham, J.L., Bullen, M.F., Evans, D.A.P.: The pharmacokinetics of acetanilide and of diphenylhydantoin sodium. Eur. J. Clin. Pharmacol. 7, 461–466 (1974)

    Google Scholar 

  • Das, P.K.: Further evidence on the heterogeneity of 'silent’ serum cholinesterase variants. Hum. Hered. 23, 88–96 (1973)

    Google Scholar 

  • Dengler, H.J., Eichelbaum, M.: Polymorphismen und Defekte des Arzneimittelstoff-wechsels als Ursache toxischer Reaktionen. Arzneim. Forsch. 27, 1836–1844 (1977)

    Google Scholar 

  • Desforges, J.F.: Genetic implications of G-6-PD deficiency. N. Engl. J. Med. 294, 1438–1440 (1976)

    Google Scholar 

  • Dorus, E., Pandey, G.N., Davis, J.M.: Genetic determinant of lithium ion distribution. Arch. Gen. Psychiat. 32, 1097–1102 (1975)

    Google Scholar 

  • Dorus, E., Pandey, G.N., Frazer, A., Mendels, J.: Genetic determinant of lithium ion distribution. I. An in vitro monozygotic-dizygotic twin study. Arch. Gen. Phychiat. 31, 463–465 (1974)

    Google Scholar 

  • Drayer, D.E., Reidenberg, M.M.: Clinical consequences of polymorphic acetylation of basic drugs. Clin. Pharmacol. Ther. 22, 251–258 (1977)

    Google Scholar 

  • Drummond, D.: Rats resistant to warfarin. New Sci. 30, 771–772 (1966)

    Google Scholar 

  • Edwards, J.A., Evans, D.A.P.: Ethanol metabolism in subjects possessing typical and atypical liver alcohol dehydrogenase. Clin. Pharmacol. Ther. 8, 824–829 (1967)

    Google Scholar 

  • Eidus, L., Harnanansingh, M.T.: A more sensitive spectrophotometric method for determination of isoniazid in serum or plasma. Clin. Chem. 17, 492–494 (1971)

    Google Scholar 

  • Ellard, G.A., Gammon, P.T.: Pharmacokinetics of isoniazid metabolism in man. J. Pharmacokinet. Biopharm. 4, 83–113 (1976)

    Google Scholar 

  • Emery, A.E.H., Anand, R., Danford, N., Duncan, W.: Aryl-hydrocarbon-hydroxylase inducibility in patients with lung cancer. Lancet 1978/I, 470–472

    Google Scholar 

  • Endrenyi, L., Inaba, T., Kalow, W.: Genetic study of amobarbital elimination based on its kinetics in twins. Clin. Pharmacol. Ther. 20, 701–714 (1976)

    Google Scholar 

  • Evans, D.A.P.: An improved and simplified method of detecting the acetylator phenotype. J. Med. Genet. 6, 405–407 (1969)

    Google Scholar 

  • Evans, D.A.P., Davidson, K., Pratt, R.T.C.: The influence of acetylator phenotype on the effect of treating depression with phenelzine. Clin. Pharmacol. Ther. 6, 430–435 (1965)

    Google Scholar 

  • Evans, D.A.P., Manley, K., McKusick, V.A.: Genetic control of isoniazid metabolism in man. Brit. Med. J. 2, 485–491 (1960)

    Google Scholar 

  • Evans, D.A.P., White, T.A.: Human acetylation polymorphism. J. Lab. Clin. Med. 63, 394–403 (1964)

    Google Scholar 

  • Ewing, J.A., Rouse, B.A., Pellizzari, E.D.: Alcohol sensitivity and ethnic background. Am. J. Psychiat. 131, 206–210 (1974)

    Google Scholar 

  • Farris, J.J., Jones, B.M.: Ethanol metabolism in male American Indians and Whites. Alcoholism. Clin. Exp. Res. 2, 77–81 (1978)

    Google Scholar 

  • Fenna, D., Mix, L., Schaefer, O., Gilbert, J.A.L.: Ethanol metabolism in various racial groups. Can. Med. Assoc. J. 105, 472–475 (1971)

    Google Scholar 

  • Flatz, G., Xirotiris, N.: Glukose-6-Phosphat-Dehydrogenase. In: Humangenetik. Ein kurzes Handbuch in fünf Bänden. Becker, P.E. (ed.). Stuttgart: Thieme 1975, Vol. I/3, p. 494–535

    Google Scholar 

  • Freese, E., Sklarow, S., Freese, E.B.: DNA damage caused by antidepressant hydrazines and related drugs. Mutat. Res. 5, 343–348 (1968)

    Google Scholar 

  • Fukui, M., Wakasugi, C.: Liver alcohol dehydrogenase in a Japanese population. Jap. J. Leg. Med. 26, 46–51 (1972)

    Google Scholar 

  • Furst, D.E., Gupta, N., Paulus, H.E.: Salicylate metabolism in twins. Evidence suggesting a genetic influence and induction of salicylate formation. J. Clin. Invest. 60, 32–42 (1977)

    Google Scholar 

  • Garry, P.J., Dietz, A.A., Lubrano, T., Ford, P.C., James, K., Rubinstein, H.M.: New allele at cholinesterase locus 1. J. Med. Genet. 13, 38–42 (1976)

    Google Scholar 

  • Gelber, R., Peters, J.H., Gordon, G.R., Glazko, A.J., Levy, L.: The polymorphic acetylation of dapsone in man. Clin. Pharmacol. Ther. 12, 225–238 (1971)

    Google Scholar 

  • Geldmacher-v. Mallinckrodt, M., Lindorf, H.H., Petenyi, M., Flügel, M., Fischer, T., Hiller, T.: Genetisch determinierter Polymorphismus der menschlichen Serum-Para-oxonase(ED 3.1.1.2). Humangenetik 17, 331–335 (1973)

    Google Scholar 

  • Goedde, H.W.: Pseudocholinesterase variation. Internat. Titisee Conference, Oct. 13–15, 1977. Hum. Genet. (in press)

    Google Scholar 

  • Goedde, H.W., Airland, K., Schloot, W. (eds.): Pharmacogenetics. Hum. Genet. 9, 197–280 (1970)

    Google Scholar 

  • Goedde, H.W., Doenicke, A., Altland, K.: Pseudocholinesterasen. Berlin-Heidelberg-New York: Springer 1967

    Google Scholar 

  • Goedde, H.W., Löhr, G.W., Waller, H.D.: Ergebnisse und Probleme der Pharmakogenetik. Arzneim. Forsch. 15, 1460–1468 (1965)

    Google Scholar 

  • Goldsmith, R.J., Rothhammer, F., Schull, W.J.: Mydriasis and heredity. Clin. Genet. 12, 129–133 (1977)

    Google Scholar 

  • Grafe, A., Lorenz, R., Vollmar, J.: Testing the mutagenic potency of chemical substances in a linear host-mediated assay. Mutat. Res. 31, 205–216 (1975)

    Google Scholar 

  • Greil, W., Eisenried, F., Becker, B.F., Duhm, J.: Interindividual differences in the Na+-dependent Li+ countertransport system and in the Li+ distribution ratio across the red cell membrane among Li+-treated patients. Psychopharmacol. 53, 19–26 (1977)

    Google Scholar 

  • Gutsche, B.B., Scott, E.M., Wright, R.C.: Hereditary deficiency of pseudocholinesterase in Eskimos. Nature 215, 322–323 (1967)

    Google Scholar 

  • Hanna, J.M.: Metabolic responses of Chinese, Japanese and Europeans to alcohol. Alcoholism. Clin. Exp. Res. 2, 89–92 (1978)

    Google Scholar 

  • Harada, S., Agarwal, D.P., Goedde, H.W.: Human liver alcohol dehydrogenase isoenzyme variations. Hum. Genet. 40, 215–220 (1978)

    Google Scholar 

  • Harris, C.C., Autrup, H., Connor, R., Barrett, L.A., McDowell, E.M., Trump, B.F.: Interindividual variation in binding of benzo(a)pyrene to DNA in cultured human bronchi. Science 194, 1067–1069 (1976)

    Google Scholar 

  • Harris, H., Hopkinson, D.A.: Average heterozygosity per locus in man: an estimate based on the incidence of enzyme polymorphisms. Ann. Hum. Genet. 36, 9–20 (1972)

    PubMed  Google Scholar 

  • Heuschert, D.: EEG-Untersuchungen an eineiigen Zwillingen in höherem Lebensalter. Z. Menschl. Vererb. Konstitut.-Lehre 37, 128–172 (1963)

    Google Scholar 

  • Hoo, J.-J., Hussein, L., Goedde, H.W.: A simplified micromethod for the determination of the acetylator phenotype. J. Clin. Chem. Clin. Biochem. 15, 329–332 (1977)

    Google Scholar 

  • Hughes, H.B., Biehl, J.P., Jones, A.P., Schmidt, L.H.: Metabolism of isoniazid in man as related to occurrence of peripheral neuritis. Am. Rev. Tuberc. 70, 266–273 (1954)

    Google Scholar 

  • Idle, J.R., Mahgoub, A., Lancaster, R., Smith, R.L.: Hypotensive response to debrisoquine and hydroxylation phenotype. Life Sci. 22, 979–984 (1978)

    Google Scholar 

  • Itil, T.: Quantitative pharmaco-electroencephalography. Use of computerized cerebral biopotentials in psychotropic drug research. In: Psychotropic Drugs and the Human EEG. Itil, T.M. (ed.). Basel: Karger 1974, p. 43–75

    Google Scholar 

  • Jenne, J.W., Orser, M.: Partial purification and properties of the isoniazid trans-acetylase in the human liver. Its relationship to the acetylation of p-aminosalicylic acid. J. Clin. Invest. 44, 1992–2002 (1965)

    Google Scholar 

  • Jessamine, A.G., Hodghkin, M.M., Eidus, L.: Urine tests for phenotyping slow and fast acetylators. Can. J. Public Health 65, 119–123 (1974)

    Google Scholar 

  • Jinks, J.L., Fulker, D.W.: Comparison of the biometrical, genetical, MAVA and classical approaches to the analysis of human behaviour. Psychol. Bull. 73, 311–349 (1970)

    Google Scholar 

  • Johnston, F.E., Blumberg, B.S., Agarwal, S.S., Melartin, L., Burch, T.A.: Alloalbuminemia in southwestern U.S. Indians. Polymorphism of albumin Naskapi and albumin Mexico. Hum. Biol. 41, 263–270 (1969)

    Google Scholar 

  • Johnstone, E.C.: The relationship between acetylator status and inhibition of monoamine oxidase, excretion of free drug and antidepressant response in depressed patients on phenelzine. Psychopharmacology 46, 289–294 (1976)

    Google Scholar 

  • Johnstone, E., Marsh, W.: Acetylator status and response to phenelzine in depressed patients. Lancet 1973/I, 567–570 (1973)

    Google Scholar 

  • Juel-Nielsen, N., Harvald, B.: The electroencephalogram in uniovular twins brought up apart. Acta Genet. Statist. Med. 8, 57–64 (1958)

    Google Scholar 

  • Kahn, A.: G6PD variants. Internat. Titisee Conference, Oct. 13–15, 1977. Hum. Genet. (in press)

    Google Scholar 

  • Kalow, W.: Pharmacogenetics. Heredity and the Response to Drugs. Philadelphia: Saunders 1962

    Google Scholar 

  • Kalow, W.: Succinylcholine and malignant hyperthermia. Fed. Proc. 31, 1270–1275 (1972)

    Google Scholar 

  • Kalow, W., Britt, B.A., Richter, A.: The caffeine test of isolated human muscle in relation to malignant hyperthermia. Can. Anaesth. Soc. J. 24, 678–694 (1977a)

    Google Scholar 

  • Kalow, W., Kadar, D., Inaba, T., Tang, B.K.: Case of deficiency of N-hydroxylation of amobarbital. Clin. Pharmacol. Ther. 21, 530–535 (1977 b)

    Google Scholar 

  • Karim, A.K.M.B., Evans, D.A.P.: Polymorphic acetylation of nitrazepam. J. Med. Genet. 13, 17–19 (1976)

    Google Scholar 

  • Karlsson, E., Aberg, G., Collste, P., Molin, L., Norlander, B., Sjöqvist, F.: Acetylation of procaine amide in man. A preliminary communication. Eur. J. Clin. Pharmacol. 8, 79–81 (1975)

    Google Scholar 

  • Kellermann, G., Luyten-Kellermann, M., Shaw, C.R.: Genetic variation of aryl hydrocarbon hydroxylase in human lymphocytes. Am. J. Hum. Genet. 25, 327–331 (1973a)

    Google Scholar 

  • Kellermann, G., Shaw, C.R., Luyten-Kellermann, M.: Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma. N. Engl. J. Med. 289, 934–937 (1973b)

    Google Scholar 

  • Kimball, R.F.: The mutagenicity of hydrazine and some of its derivatives. Mutat. Res. 39, 111–126 (1977)

    Google Scholar 

  • Kirkman, H.N.: Glucose-6-phosphate dehydrogenase. Adv. Hum. Genet. 2, 1–60 (1971)

    Google Scholar 

  • Klein, H., Fahrig, H., Wolf, H.P.: Die Bestimmung der Alkoholdehydrogenase-und Glutaminsäure-Oxalessigsäure-Transaminase-Aktivität der menschlichen Leber nach dem Tode. Dtsch. Z. Ges. Gerichtl. Med. 52, 615–629 (1962)

    Google Scholar 

  • Knight, R.A., Selin, J., Harris, H.W.: Genetic factors influencing isoniazid blood levels in humans. In: Transactions of Conference on Chemotherapy of Tuberculosis, 18th Conf. 1959, p. 52–58

    Google Scholar 

  • Knorring, L. v., Oreland, L., Perris, C., Wiberg, A.: Evaluation of the lithium RBC/plasma ratio as a predictor of the prophylactic effect of lithium treatment in affective disorders. Pharmakopsychiatr. 9, 81–84 (1976)

    Google Scholar 

  • Koch-Weser, J.: Drug therapy: hydralazine. N. Engl. J. Med. 295, 320–323 (1976)

    Google Scholar 

  • Koch-Weser, J.: Serum procainamide levels as therapeutic guides. Clin. Pharmacokinet. 2, 389–402 (1977)

    Google Scholar 

  • Kopun, M., Propping, P.: The kinetics of ethanol absorption and elimination in twins and supplementary repetitive experiments in singleton subjects. Eur. J. Clin. Pharmacol. 11, 337–344 (1977)

    Google Scholar 

  • Koukkou, M., Lehmann, D.: Human EEG spectra before and during cannabis hallucinations. Biol. Psychiat. 11, 663–677 (1976)

    Google Scholar 

  • Kutt, H.: Biochemical and genetic factors regulating dilantin metabolism in man. Ann. N.Y. Acad. Sci. 179, 704–722 (1971)

    Google Scholar 

  • Kutt, H., Wolk, M., Scherman, R., McDowell, F.: Insufficient parahydroxylation as a cause of diphenylhydantoin toxicity. Neurology 14, 542–548 (1964)

    PubMed  Google Scholar 

  • La Du, B.N.: Isoniazid and pseudocholinesterase polymorphisms. Fed. Proc. 31, 1276–1285 (1972)

    Google Scholar 

  • La Du, B.N., Kalow, W.: Pharmacogenetics. Ann. N.Y. Acad. Sci. 151, Art. 2, 691–1001 (1968)

    Google Scholar 

  • Langenbeck, U.: Albumin. In: Humangenetik. Ein kurzes Handbuch in fünf Bänden. Becker, P.E. (ed.). Stuttgart: Thieme 1975, Vol. I/3, p. 1–34

    Google Scholar 

  • Lenz, F.: Inwieweit kann man aus Zwillingsbefunden auf Erbbedingtheit und Umwelteinfluß schließen? Dtsch. Med. Wschr. 61, 873–875 (1935)

    Google Scholar 

  • Lewis, R.J., Spivack, M., Spaet, T.H.: Warfarin resistance. Am. J. Med. 42, 620 (1967)

    Google Scholar 

  • Lüth, K.-F.: Untersuchungen über die Alkoholblutkonzentration nach Alkoholgaben bei 10 eineiigen und 10 zweieiigen Zwillingspaaren. Dtsch. Z. Gerichtl. Med. 32, 145–164 (1939)

    Google Scholar 

  • Luzzatto, L.: New developments in glucose-6-phosphate dehydrogenase deficiency. Isr. J. Med. Sci. 9, 1484–1498 (1973)

    Google Scholar 

  • Luzzatto, L.: Inherited haemolytic states: glucose-6-phosphate dehydrogenase deficiency. Clin. Haematol. 4, 83–108 (1975)

    Google Scholar 

  • Mahgoub, A., Idle, J.R., Dring, L.G., Smith, R.L.: Polymorphic hydroxylation of de-brisoquine in man. Lancet 1977/II, 584–586

    Google Scholar 

  • Mattila, M.J., Tiitinen. H., Alhava, E.: Acetylation pattern of different sulphonamides in rapid and slow isoniazid inactivators. Ann. Med. Exp. Fenn. 47, 308–315 (1969)

    Google Scholar 

  • Melartin, L.: Albumin polymorphism in man. Studies on albumin variants in North American native populations. Acta Pathol. Microbiol. Scand. (Suppl.) 191, 1–50 (1967)

    Google Scholar 

  • Mendels, J., Frazer, A.: Intracellular lithium concentration and clinical response: towards a membrane theory of depression. J. Psychiatr. Res. 10, 9–18 (1973)

    Google Scholar 

  • Mendels, J., Frazer, A., Baron, J., Kukopulos, A., Reginaldi, D., Tondo, L., Caliari, B.: Intra-erythrocyte lithium ion concentration and long-term maintenance treatment. Lancet 1976/I, 966

    Google Scholar 

  • Mendlewicz, J., Fieve, R., Stallone, F.: Relationship between the effectiveness of lithium therapy and family history. Am. J. Psychiat. 130, 1011–1013 (1973)

    Google Scholar 

  • Mitchell, J.R., Thorgeirson, U.P., Black, M., Timbrell, J.A., Snodgrass, W.R., Potter, W.Z., Jollow, D.J., Keiser, H.R.: Increased incidence of isoniazid hepatitis in rapid acetylators — possible relation to hydrazine metabolites. Clin. Pharmacol. Ther. 18, 70–79 (1975)

    Google Scholar 

  • Motulsky, A.G. (ed.): Pharmacogenetics and ecogenetics. Internat. Titisee Conference, Oct. 13–15, 1977. Hum. Genet. (in press)

    Google Scholar 

  • Müller-Oerlinghausen, B.: Bedeutung der Pharmakokinetik für die Therapie mit Anti-depressiva. Pharmakopsychiat. 11, 55–62 (1978)

    Google Scholar 

  • Naito, S.-F., Nelson, E.: Acetylation of sulfamethylthiodiazole. J. Pharm. Sci. 52, 707 (1963)

    Google Scholar 

  • Omenn, G.S., Motulsky, A.G.: Psychopharmacogenetics. In: Human Behavior Genetics. Kaplan, A.R. (ed.). Springfield (Ill.): Charles C. Thomas 1976, p. 363–384

    Google Scholar 

  • O'Reilly, R.A.: The second reported kindred with hereditary resistance to oral anticoagulant drugs. N. Engl. J. Med. 282, 1448–1451 (1970)

    Google Scholar 

  • O'Reilly, R.A.: Genetic factors in the response to oral anticoagulant drugs. Proc. 4th Int. Congr. Hum. Genet. (Paris), Sept. 6–11, 1971. Excerpta Med. Int. Congr. Ser. No. 250, 428–442 (1972)

    Google Scholar 

  • O'Reilly, R.A., Aggeler, P.M., Hoag, M.S., Leong. L.S., Kropatkin, M.L.: Hereditary transmission of exceptional resistance to coumarin anti-coagulant drugs. The first reported kindred. N. Engl. J. Med. 271, 809–815 (1964)

    Google Scholar 

  • Paigen, B., Gurtoo, H.L., Minowada, J., Houten, L., Vincent, R., Paigen, K., Bejba Parker, N., Ward, E., Thompson Hayner, N.: Questionable relation of aryl hydrocarbon hydroxylase to lung-cancer risk. N. Engl. J. Med. 297, 346–350 (1977)

    Google Scholar 

  • Pandey, G.N., Ostrow, D.G., Haas, M., Doras, E., Casper, R.C., Davis, J.M.: Abnormal lithium and sodium transport in erythrocytes of a manic patient and some members of his family. Proc. Natl. Acad. Sci. USA 74, 3607–3611 (1977)

    Google Scholar 

  • Pare, C.M.B., Mack, J.W.: Differentiation of two genetically specific types of depression by the response to antidepressant drugs. J. Med. Genet. 8, 306–309 (1971)

    Google Scholar 

  • Pare, C.M.B., Rees, L., Sainsbury, M.J.: Differentiation of two genetically specific types of depression by the response to anti-depressants. Lancet 1962/II, 1340–1343

    Google Scholar 

  • Perry, H.M., Tan, E.M., Carmody, S., Sakamoto, A.: Relationship of acetyltransferase activity to antinuclear antibodies and toxic symptoms in hypertensive patients treated with hydralazine. J. Lab. Clin. Med. 76, 114–125 (1970)

    Google Scholar 

  • Piafsky, K.M., Borga, O.: Plasma protein binding of basic drugs. II. Importance of α1-acid glycoprotein for interindividual variation. Clin. Pharmacol. Ther. 22, 545–549 (1977)

    Google Scholar 

  • Playfer, J.R., Eze, L.C., Bullen, M.F., Evans, D.A.P.: Genetic polymorphism and inter-ethnic variability of plasma paroxonase activity. J. Med. Genet. 13, 337–342 (1976)

    Google Scholar 

  • Pool, J.G., O'Reilly, R.A., Schneidermann, L.J., Alexander, M.: Warfarin resistance in the rat. Am. J. Physiol. 215, 627–631 (1968)

    Google Scholar 

  • Propping, P.: Genetic control of ethanol action on the central nervous system. An EEG study in twins. Hum. Genet. 35, 309–334 (1977)

    Google Scholar 

  • Propping, P., Kopun, M.: Pharmacogenetic aspects of psychoactive drugs: Facts and fancy. Hum. Genet. 20, 291–320 (1973)

    Google Scholar 

  • Reed, T.E., Kalant, H., Gibbins, R.J., Kapur, B.M., Rankin, J.G.: Alcohol and acetal-dehyde metabolism in Caucasians, Chinese and Amerinds. Can. Med. Assoc. J. 115, 851–855 (1976)

    Google Scholar 

  • Reidenberg, M.M.: Acetylation polymorphism in man. Internat. Titisee Conference, Oct. 13–15, 1977. Hum. Genet. (in press)

    Google Scholar 

  • Reidenberg, M.M., Drayer, D., DeMarco, A.L., Bello, C.T.: Hydralazine elimination in man. Clin. Pharmacol. Ther. 14, 970–977 (1973)

    Google Scholar 

  • Reidenberg, M.M., Drayer, D.E., Levy, M., Warner, H.: Polymorphic acetylation of procainamide in man. Clin. Pharmacol. Ther. 17, 722–730 (1975)

    Google Scholar 

  • Remmer, H., Hirschmann, J., Greiner, I.: Die Bedeutung von Kumulation und Elimination für die Dosierung von Phenytoin (Diphenylhydantoin). Dtsch. Med. Wschr. 94, 1265–1272 (1969)

    PubMed  Google Scholar 

  • Röhrborn, G., Propping, P., Buselmaier, W.: Mutagenic activity of isoniazid and hydrazine in mammalian test systems. Mutat. Res. 16, 189–194 (1972)

    Google Scholar 

  • Rubinstein, H.M., Dietz, A.A., Lubrano, T.: E k1 , another quantitative variant at cholinesterase locus 1. J. Med. Genet. 15, 27–29 (1978)

    Google Scholar 

  • Rüdiger, H.W., Kohl, F., Mangels, W., Wichert, P. v., Bartram, C.R., Wöhler, W., Passarge, E.: Benzpyrene induces sister chromatid exchanges in cultured human lymphocytes. Nature 262, 290–292 (1976)

    Google Scholar 

  • Rybakowski, J.: Pharmacogenetic aspect of red blood cell lithium index in manic-depressive psychosis. Biol. Psychiat. 12, 425–429 (1977)

    Google Scholar 

  • Rybakowski, J., Strzyzewski, W.: Red-blood-cell lithium index and long-term maintenance treatment. Lancet 1976/I, 1408–1409

    Google Scholar 

  • Sachsenheimer, W., Pai, E.F., Schulz, G.E., Schirmer, R.H.: Halothane binds in the adenine-specific niche of crystalline adenylate kinase. FEBS Lett. 79, 310–312 (1977)

    Google Scholar 

  • Sauter, A.M., Boss, D., Wartburg, J.-P. v.: Reevaluation of the disulfiram-alcohol reaction in man. J. Stud. Alcohol. 38, 1680–1695 (1977)

    Google Scholar 

  • Schloot, W., Blume, K.G., Goedde, H.W., Flatz, G., Bhaibulaya, M.: Studies on isoniazid conversion in Thailand. Hum. Genet. 4, 274–279 (1967)

    Google Scholar 

  • Schmitt, J., Schmidt, K., Ritter, H.: Hereditary malignant hyperpyrexia associated with muscle adenylate kinase deficiency. Hum. Genet. 24, 253–257 (1974)

    Google Scholar 

  • Schöneich, J.: Safety evaluation based on microbial assay procedure. Mutat. Res. 41, 89–94 (1976)

    Google Scholar 

  • Schönwald, A D., Bartram, C.R., Rüdiger, H.W.: Benzpyrene-induced sister chromatid exchanges in lymphocytes of patients with lung cancer. Hum. Genet. 36, 261–264 (1977)

    Google Scholar 

  • Schröder, H., Evans, D.A.P.: The polymorphic acetylation of sulphapyridine in man. J. Med. Genet. 9, 168–171 (1972)

    Google Scholar 

  • Schwartz, J.T., Reuling, F.H., Feinleib, M., Garrison, R.J., Collie, D.J.: Twin heritability study of the effect of corticosteroids on intraocular pressure. J. Med. Genet. 9, 137–143 (1972)

    Google Scholar 

  • Shahidi, N.T.: Acetophenetidin-induced methemoglobinemia. Ann. N. Acad. Sci. 151, 822–832 (1968)

    Google Scholar 

  • Smith, M., Hopkinson, D.A., Harris, H.: Developmental changes and polymorphism in human alcohol dehydrogenase. Ann. Hum. Genet. 34, 251–271 (1971)

    Google Scholar 

  • Stamatoyannopoulos, S., Chen, S.-H., Fukui, M.: Liver alcohol dehydrogenase in Japanese: High population frequency of atypical form and its possible role in alcohol sensitivity. Am. J. Hum. Genet. 27, 789–796 (1975)

    Google Scholar 

  • Stanbury, J.B., Wyngaarden, J.B., Fredrickson, D.S.: The Metabolic Basis of Inherited Disease. New York: McGraw Hill 1972

    Google Scholar 

  • Steegmüller, H.: Geographical distribution of pseudocholinesterase variants. Hum. Genet. 26, 167–185 (1975)

    Google Scholar 

  • Talseth, T.: Kinetics of hydralazine elimination. Clin. Pharmacol. Ther. 21, 715–720 (1977)

    Google Scholar 

  • Tang, B.K., Inaba, T., Kalow, W.: N-hydroxyamobarbital, the second major metabolite of amobarbital in man. Drug Metabl. Dispos. 3, 479–486 (1975)

    Google Scholar 

  • Timbrell, J.A., Wright, J.M., Baillie, T.: Monoacetylhydrazine as a metabolite of isoniazid in man. Clin. Pharmacol. Ther. 22, 602–608 (1977)

    Google Scholar 

  • Vesell, E.S. (ed.): Drug metabolism in man. Ann. N.Y. Acad. Sci. 179, 1–773 (1971)

    Google Scholar 

  • Vesell, E.S.: Advances in pharmacogenetics. Prog. Med. Genet. 9, 291–367 (1973)

    Google Scholar 

  • Vesell, E.S.: Twin studies in pharmacogenetics. Internat. Titisee Conference, Oct. 13–15, 1977. Hum. Genet. (in press)

    Google Scholar 

  • Vesell, E.S., Page, J.G.: Genetic control of drug levels in man: Antipyrine. Science 161, 72–73 (1968a)

    PubMed  Google Scholar 

  • Vesell, E.S., Page, J.G.: Genetic control of drug levels in man: Phenylbutazone. Science 159, 1479–1480 (1968b)

    Google Scholar 

  • Vesell, E.S., Page, J.G.: Genetic control of dicoumarol levels in man. J. Clin. Invest. 47, 2657–2663 (1968c)

    Google Scholar 

  • Vesell, E.S., Page, J.G., Passananti, T.G.: Genetic and environmental factors affecting ethanol metabolism in man. Clin. Pharmacol. Ther. 12, 192–201 (1971)

    Google Scholar 

  • Vogel, F.: Moderne Probleme der Humangenetik. Ergebn. Inn. Med. Kinderheilk. 12, 52–125 (1959)

    Google Scholar 

  • Vogel, F.: The genetic basis of the normal human electroencephalogram (EEG). Hum. Genet. 10, 91–114 (1970)

    Google Scholar 

  • Wagner, J.G.: Intrasubject variation in elimination half-lives of drugs which are appreciably metabolized. J. Pharmacokinet. Biopharm. 1, 165–173 (1973)

    Google Scholar 

  • Wagner, J.G., Patel, J.A.: Variations in absorption and elimination rates of ethyl alcohol in a single subject. Res. Commun. Chem. Pathol. Pharmacol. 4, 61–76 (1972)

    Google Scholar 

  • Wartburg, J.P. v., Papenberg, J., Aebi, H.: An atypical human alcohol dehydrogenase. Can. J. Biochem. 43, 889–898 (1965)

    Google Scholar 

  • Wartburg, J.P. v., Schürch, P.M.: Atypical human liver alcohol dehydrogenase. Ann. N.Y. Acad. Sci. 151, 936–946 (1968)

    Google Scholar 

  • Weber, W.W., Cohen, S.N.: The mechanism of isoniazid acetylation by human N-ace-tyltransferase. Biochim. Biophys. Acta 151, 276–278 (1968)

    Google Scholar 

  • White, T.A., Evans, D.A.P.: The acetylation of sulfamethazine and sulfamethoxypyridazine by human subjects. Clin. Pharmacol. Ther. 9, 80–88 (1968)

    Google Scholar 

  • Whittaker, J.A., Evans, D.A.P.: Genetic control of phenylbutazone metabolism in man. Brit. Med. J. 4, 323–328 (1970)

    Google Scholar 

  • Wilding, G., Blumberg, B.S., Vesell, E.S.: Reduced warfarin binding of albumin variants. Science 195, 991–994 (1977)

    Google Scholar 

  • WHO Techn. Rep. Ser. No. 509 (1972): Treatment of heamoglobinopathies and allied disorders.

    Google Scholar 

  • WHO Techn. Rep. Ser. No. 524 (1973): Pharmacogenetics.

    Google Scholar 

  • Wolff, P.H.: Ethnic differences in alcohol sensitivity. Science 175, 449–450 (1972)

    Google Scholar 

  • Wolff, P.H.: Vasomotor sensitivity to alcohol in diverse mongoloid populations. Am. J. Hum. Genet. 25, 193–199 (1973)

    Google Scholar 

  • Zimmermann, A., Matschiner, J.T.: Biochemical basis of hereditary resistance to warfarin in the rat. Biochem. Pharmacol. 23, 1033–1040 (1974)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Anthropologie und Humangenetik der Universität Heidelberg, Im Neuen-heimer Feld 328, D-6900, Heidelberg

    Peter Propping

Authors
  1. Peter Propping
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1978 Springer-Verlag

About this chapter

Cite this chapter

Propping, P. (1978). Pharmacogenetics. In: Reviews of Physiology, Biochemistry and Pharmacology, Volume 83. Reviews of Physiology, Biochemistry and Pharmacology, vol 83. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-08907-1_4

Download citation

  • DOI: https://doi.org/10.1007/3-540-08907-1_4

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-08907-0

  • Online ISBN: 978-3-540-35785-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation