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Nucleophilic Carbenes as Organocatalysts

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Organocatalysis

Part of the book series: Ernst Schering Foundation Symposium Proceedings ((SCHERING FOUND,volume 2007/2))

Abstract

N-Heterocyclic carbenes (NHC) have become an important class of organocatalysts and class of ligands for transition-metal catalysis. In organocatalyzed umpolung reactions, thiazolium salt-derived NHC have been used successfully for decades. Even so, during recent years there has been an increased interest in NHC-catalyzed transformations and many new reactions have been developed. This article focuses on the use of NHC in the conjugate umpolung of α,β-unsaturated aldehydes.

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Acknowledgements

Generous financial support by the Deutsche Forschungsgemeinschaft (Priority program organocatalysis), the Fonds der Chemischen Industrie (Dozentenstipendium for F.G.), the Deutsche Akademische Austauschdienst (fellowship for K.H.) and the BASF AG (BASF Catalysis Award to F.G.) as well as donations by Bayer AG are gratefully acknowledged. In addition, the research of F.G. was also generously supported by the Alfried Krupp Prize for Young University Teachers of the Alfried Krupp von Bohlen und Halbach Foundation.

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Authors and Affiliations

  1. Organisch Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149, Münster, Germany

    F. Glorius & K. Hirano

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  1. F. Glorius
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  2. K. Hirano
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Correspondence to F. Glorius .

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M.T. Reetz B. List S. Jaroch H. Weinmann

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© 2008 Springer-Verlag

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Glorius, F., Hirano, K. (2008). Nucleophilic Carbenes as Organocatalysts. In: Reetz, M., List, B., Jaroch, S., Weinmann, H. (eds) Organocatalysis. Ernst Schering Foundation Symposium Proceedings, vol 2007/2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/2789_2008_081

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