Abstract
Head and neck radiotherapy is a continuously evolving field. The disease itself has changed with the increase in human papilloma virus (HPV) associated oropharyngeal cancer. With this new disease entity, oncologists are struggling to determine optimal therapy. As radiation oncologists, we are questioning our traditional use of chemotherapy as well as our radiation doses and volumes.
References
Abidia A, Laden G, Kuhan G et al (2003) The role of hyperbaric oxygen therapy in ischaemic diabetic lower extremity ulcers: a double-blind randomised-controlled trial. Eur J Vasc Endovasc Surg 25:513–518
Ang KK, Harris J, Wheeler R et al (2010) Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 363:24–35
Annane D, Depondt J, Aubert P et al (2004) Hyperbaric oxygen therapy for radionecrosis of the jaw: a randomized, placebo-controlled, double-blind trial from the ORN96 study group. J Clin Oncol 22:4893–4900
Antonadou D, Pepelassi M, Synodinou M et al (2002) Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer. Int J Radiat Oncol Biol Phys 52:739–747
Ares C, Hug EB, Lomax AJ et al (2009) Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base: first long-term report. Int J Radiat Oncol Biol Phys 75:1111–1118
Battermann JJ, Breur K, Hart GA et al (1981) Observations on pulmonary metastases in patients after single doses and multiple fractions of fast neutrons and cobalt-60 gamma rays. Eur J Cancer 17:539–548
Blom M, Dawidson I, Fernberg JO et al (1996) Acupuncture treatment of patients with radiation-induced xerostomia. Eur J Cancer B Oral Oncol 32b:182–190
Brizel DM, Wasserman TH, Henke M et al (2000) Phase III randomized trial of amifostine as a radioprotector in head and neck cancer. J Clin Oncol 18:3339–3345
Buentzel J, Micke O, Adamietz IA et al (2006) Intravenous amifostine during chemoradiotherapy for head-and-neck cancer: a randomized placebo-controlled phase III study. Int J Radiat Oncol Biol Phys 64:684–691
Catton C, O’Sullivan B, Bell R et al (1996) Chordoma: long-term follow-up after radical photon irradiation. Radiother Oncol 41:67–72
Chan AW, Liebsch LJ, Deschler DG, Adams JA, Vrishali LV, McIntyre JF, Pommier P, Fabian RL, Busse PM (2004) Proton radiotherapy for T4 nasopharyngeal carcinoma. J Clin Oncol 22:5574
Chan A, Adams JA, Weyman E et al (2012) A phase II trial of proton radiation therapy with chemotherapy for nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 84:S151–S152
Chera BS, Amdur RJ, Tepper J et al (2015) Phase 2 trial of de-intensified chemoradiation therapy for favorable-risk human papillomavirus-associated oropharyngeal squamous cell carcinoma. Int J Radiat Oncol Biol Phys 93:976–985
Cho JH, Chung WK, Kang W et al (2008) Manual acupuncture improved quality of life in cancer patients with radiation-induced xerostomia. J Altern Complement Med 14:523–526
Chronowski GM, Garden AS, Morrison WH et al (2012) Unilateral radiotherapy for the treatment of tonsil cancer. Int J Radiat Oncol Biol Phys 83:204–209
Clarke RE, Tenorio LM, Hussey JR et al (2008) Hyperbaric oxygen treatment of chronic refractory radiation proctitis: a randomized and controlled double-blind crossover trial with long-term follow-up. Int J Radiat Oncol Biol Phys 72:134–143
Cmelak A, Li S, Marur S, Zhao W, Westra WH, Chung CH, Gillison ML, Gilbert J, Bauman JE, Wagner LI, Ferris RL, Trevarthen DR, Dimitrios Colevas A, Jahagirdar BN, Burtness B (2014) E1308: reduced-dose IMRT in human papillomavirus (HPV)-associated resectable oropharyngeal squamous carcinomas (OPSCC) after clinical complete response (CCR) to induction chemotherapy (IC). J Clin Oncol 32:LBA6006
Cohen EE, Karrison TG, Kocherginsky M et al (2014) Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. J Clin Oncol 32:2735–2743
Delanian S, Lefaix JL (2002) Radionécrose de l’os mature: connaissance physiopathologique récente motrice d’une thérapeutique médicale innovante. Cancer/Radiothérapie 6:1–9
Delanian S, Balla-Mekias S, Lefaix JL (1999) Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol. J Clin Oncol 17:3283–3290
Delanian S, Chatel C, Porcher R et al (2011) Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase ii trial. Int J Radiat Oncol Biol Phys 80:832–839
Dhanda J, Pasquier D, Newman L et al (2016) Current concepts in osteoradionecrosis after head and neck radiotherapy. Clin Oncol (R Coll Radiol) 28:459–466
Feehan PE, Castro JR, Phillips TL et al (1992) Recurrent locally advanced nasopharyngeal carcinoma treated with heavy charged particle irradiation. Int J Radiat Oncol Biol Phys 23:881–884
Forastiere AA, Zhang Q, Weber RS et al (2013) Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J Clin Oncol 31:845–852
Frank SJ (2016) Intensity modulated proton therapy for head and neck tumors: gilding the lily or holy grail? Int J Radiat Oncol Biol Phys 95:37–39
Gerweck LE, Kozin SV (1999) Relative biological effectiveness of proton beams in clinical therapy. Radiother Oncol 50:135–142
Gillison ML, Koch WM, Capone RB et al (2000) Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 92:709–720
Gothard L, Stanton A, MacLaren J et al (2004) Non-randomised phase ii trial of hyperbaric oxygen therapy in patients with chronic arm lymphoedema and tissue fibrosis after radiotherapy for early breast cancer. Radiother Oncol 70:217–224
Grover S, Swisher-McClure S, Mitra N et al (2015) Total laryngectomy versus larynx preservation for T4a larynx cancer: patterns of care and survival outcomes. Int J Radiat Oncol Biol Phys 92:594–601
Haddad R, Sonis S, Posner M et al (2009) Randomized phase 2 study of concomitant chemoradiotherapy using weekly carboplatin/paclitaxel with or without daily subcutaneous amifostine in patients with locally advanced head and neck cancer. Cancer 115:4514–4523
Haddad R, O’Neill A, Rabinowits G et al (2013) Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (paradigm): a randomised phase 3 trial. Lancet Oncol 14:257–264
Henke M, Alfonsi M, Foa P et al (2011) Palifermin decreases severe oral mucositis of patients undergoing postoperative radiochemotherapy for head and neck cancer: a randomized, placebo-controlled trial. J Clin Oncol 29:2815–2820
Jackson SM, Hay JH, Flores AD et al (1999) Cancer of the tonsil: the results of ipsilateral radiation treatment. Radiother Oncol 51:123–128
Jansen EP, Keus RB, Hilgers FJ et al (2000) Does the combination of radiotherapy and debulking surgery favor survival in paranasal sinus carcinoma? Int J Radiat Oncol Biol Phys 48:27–35
Jiang GL, Ang KK, Peters LJ et al (1991) Maxillary sinus carcinomas: natural history and results of postoperative radiotherapy. Radiother Oncol 21:193–200
Johnson JT, Ferretti GA, Nethery WJ et al (1993) Oral pilocarpine for post-irradiation xerostomia in patients with head and neck cancer. N Engl J Med 329:390–395
Kaczmar JM, Tan KS, Heitjan DF et al (2016) HPV-related oropharyngeal cancer: risk factors for treatment failure in patients managed with primary transoral robotic surgery. Head Neck 38:59–65
Kam MK, Leung SF, Zee B et al (2007) Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients. J Clin Oncol 25:4873–4879
Kamada T, Tsujii H, Blakely EA et al (2015) Carbon ion radiotherapy in Japan: an assessment of 20 years of clinical experience. Lancet Oncol 16:e93–e100
Kjems J, Gothelf AB, Hakansson K et al (2016) Elective nodal irradiation and patterns of failure in head and neck cancer after primary radiation therapy. Int J Radiat Oncol Biol Phys 94:775–782
Koh WJ, Laramore G, Griffin T et al (1989) Fast neutron radiation for inoperable and recurrent salivary gland cancers. Am J Clin Oncol 12:316–319
Kong L, Hu J, Guan X et al (2016) Phase I/II trial evaluating carbon ion radiotherapy for salvaging treatment of locally recurrent nasopharyngeal carcinoma. J Cancer 7:774–783
Kosaki K, Ecker S, Habermehl D et al (2012) Comparison of intensity modulated radiotherapy (IMRT) with intensity modulated particle therapy (IMPT) using fixed beams or an ion gantry for the treatment of patients with skull base meningiomas. Radiat Oncol 7:44
Kouvaris JR, Kouloulias VE, Vlahos LJ (2007) Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist 12:738–747
Laramore GE, Krall JM, Griffin TW et al (1993) Neutron versus photon irradiation for unresectable salivary gland tumors: final report of an rtog-mrc randomized clinical trial. Radiation therapy oncology group. Medical research council. Int J Radiat Oncol Biol Phys 27:235–240
Le QT, Kim HE, Schneider CJ et al (2011) Palifermin reduces severe mucositis in definitive chemoradiotherapy of locally advanced head and neck cancer: a randomized, placebo-controlled study. J Clin Oncol 29:2808–2814
Lefebvre JL, Andry G, Chevalier D et al (2012) Laryngeal preservation with induction chemotherapy for hypopharyngeal squamous cell carcinoma: 10-year results of EORTC trial 24891. Ann Oncol 23:2708–2714
LeVeque FG, Montgomery M, Potter D et al (1993) A multicenter, randomized, double-blind, placebo-controlled, dose-titration study of oral pilocarpine for treatment of radiation-induced xerostomia in head and neck cancer patients. J Clin Oncol 11:1124–1131
Lewis GD, Holliday EB, Kocak-Uzel E et al (2016) Intensity-modulated proton therapy for nasopharyngeal carcinoma: decreased radiation dose to normal structures and encouraging clinical outcomes. Head Neck 38(Suppl 1):E1886–E1895
Lin R, Slater JD, Yonemoto LT et al (1999) Nasopharyngeal carcinoma: repeat treatment with conformal proton therapy: dose-volume histogram analysis. Radiology 213:489–494
Locher JL, Bonner JA, Carroll WR et al (2011) Prophylactic percutaneous endoscopic gastrostomy tube placement in treatment of head and neck cancer: a comprehensive review and call for evidence-based medicine. JPEN J Parenter Enteral Nutr 35:365–374
Marx RE (1983) Osteoradionecrosis: a new concept of its pathophysiology. J Oral Maxillofac Surg 41:283–288
Marx RE, Johnson RP, Kline SN (1985) Prevention of osteoradionecrosis: a randomized prospective clinical trial of hyperbaric oxygen versus penicillin. J Am Dent Assoc 111:49–54
Meng Z, Garcia MK, Hu C et al (2012) Randomized controlled trial of acupuncture for prevention of radiation-induced xerostomia among patients with nasopharyngeal carcinoma. Cancer 118:3337–3344
Mizoe JE, Tsujii H, Kamada T et al (2004) Dose escalation study of carbon ion radiotherapy for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys 60:358–364
Mizoe JE, Hasegawa A, Jingu K et al (2012) Results of carbon ion radiotherapy for head and neck cancer. Radiother Oncol 103:32–37
Munzenrider JE, Liebsch NJ (1999) Proton therapy for tumors of the skull base. Strahlenther Onkol 175(Suppl 2):57–63
Murdoch-Kinch CA, Kim HM, Vineberg KA et al (2008) Dose-effect relationships for the submandibular salivary glands and implications for their sparing by intensity modulated radiotherapy. Int J Radiat Oncol Biol Phys 72:373–382
Murthy AK, Hendrickson FR (1980) Is contralateral neck treatment necessary in early carcinoma of the tonsil? Int J Radiat Oncol Biol Phys 6:91–94
Myers LL, Nussenbaum B, Bradford CR et al (2002) Paranasal sinus malignancies: an 18-year single institution experience. Laryngoscope 112:1964–1969
Noel G, Feuvret L, Calugaru V et al (2005) Chordomas of the base of the skull and upper cervical spine. One hundred patients irradiated by a 3D conformal technique combining photon and proton beams. Acta Oncol 44:700–708
Nutting CM, Morden JP, Harrington KJ et al (2011) Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (parsport): a phase 3 multicentre randomised controlled trial. Lancet Oncol 12:127–136
O’Sullivan B, Warde P, Grice B et al (2001) The benefits and pitfalls of ipsilateral radiotherapy in carcinoma of the tonsillar region. Int J Radiat Oncol Biol Phys 51:332–343
O’Sullivan B, Huang SH, Siu LL et al (2013) Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis. J Clin Oncol 31:543–550
Olsen KD (2010) Reexamining the treatment of advanced laryngeal cancer. Head Neck 32:1–7
Patt HM, Tyree EB, Straube RL et al (1949) Cysteine protection against X irradiation. Science (New York, NY) 110:213–214
Pfister DG, Cassileth BR, Deng GE et al (2010) Acupuncture for pain and dysfunction after neck dissection: results of a randomized controlled trial. J Clin Oncol 28:2565–2570
Pfister DG, Spencer S, Brizel DM et al (2015) Head and neck cancers, version 1.2015. J Natl Compr Cancer Netw 13:847–855. quiz 856
Pohar S, Demarcantonio M, Whiting P et al (2015) Percutaneous endoscopic gastrostomy tube dependence following chemoradiation in head and neck cancer patients. Laryngoscope 125:1366–1371
Pommier P, Liebsch NJ, Deschler DG et al (2006) Proton beam radiation therapy for skull base adenoid cystic carcinoma. Arch Otolaryngol Head Neck Surg 132:1242–1249
Posner MR, Hershock DM, Blajman CR et al (2007) Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med 357:1705–1715
Rasey JS, Krohn KA, Menard TW et al (1986) Comparative biodistribution and radioprotection studies with three radioprotective drugs in mouse tumors. Int J Radiat Oncol Biol Phys 12:1487–1490
Resto VA, Chan AW, Deschler DG et al (2008) Extent of surgery in the management of locally advanced sinonasal malignancies. Head Neck 30:222–229
Rieken S, Habermehl D, Nikoghosyan A et al (2011) Assessment of early toxicity and response in patients treated with proton and carbon ion therapy at the Heidelberg ion therapy center using the raster scanning technique. Int J Radiat Oncol Biol Phys 81:e793–e801
Rombi B, Ares C, Hug EB et al (2013) Spot-scanning proton radiation therapy for pediatric chordoma and chondrosarcoma: clinical outcome of 26 patients treated at Paul Scherrer Institute. Int J Radiat Oncol Biol Phys 86:578–584
Rosenzweig KE, Sim SE, Mychalczak B et al (2001) Elective nodal irradiation in the treatment of non-small-cell lung cancer with three-dimensional conformal radiation therapy. Int J Radiat Oncol Biol Phys 50:681–685
Rudat V, Munter M, Rades D et al (2008) The effect of amifostine or imrt to preserve the parotid function after radiotherapy of the head and neck region measured by quantitative salivary gland scintigraphy. Radiother Oncol 89:71–80
Rutz HP, Weber DC, Goitein G et al (2008) Postoperative spot-scanning proton radiation therapy for chordoma and chondrosarcoma in children and adolescents: initial experience at Paul Scherrer Institute. Int J Radiat Oncol Biol Phys 71:220–225
Salas S, Baumstarck-Barrau K, Alfonsi M et al (2009) Impact of the prophylactic gastrostomy for unresectable squamous cell head and neck carcinomas treated with radio-chemotherapy on quality of life: prospective randomized trial. Radiother Oncol 93:503–509
Schmid E, Schlegel D, Guldbakke S et al (2003) RBE of nearly monoenergetic neutrons at energies of 36 keV-14.6 MeV for induction of dicentrics in human lymphocytes. Radiat Environ Biophys 42:87–94
Schulz-Ertner D, Nikoghosyan A, Jakel O et al (2003) Feasibility and toxicity of combined photon and carbon ion radiotherapy for locally advanced adenoid cystic carcinomas. Int J Radiat Oncol Biol Phys 56:391–398
Setton J, Lee NY, Riaz N et al (2015) A multi-institution pooled analysis of gastrostomy tube dependence in patients with oropharyngeal cancer treated with definitive intensity-modulated radiotherapy. Cancer 121:294–301
Shaw R, Forner L, Butterworth C et al (2011) Randomised controlled trials in HBO: “a call to arms” for HOPON & DAHANCA-21. Br J Oral Maxillofac Surg 49:76–77
Stiff PJ, Emmanouilides C, Bensinger WI et al (2006) Palifermin reduces patient-reported mouth and throat soreness and improves patient functioning in the hematopoietic stem-cell transplantation setting. J Clin Oncol 24:5186–5193
Vacha P, Fehlauer F, Mahlmann B et al (2003) Randomized phase iii trial of postoperative radiochemotherapy +/– amifostine in head and neck cancer. Is there evidence for radioprotection? Strahlenther Onkol 179:385–389
Villaflor VM, Melotek JM, Karrison TG et al (2016) Response-adapted volume de-escalation (RAVD) in locally advanced head and neck cancer. Ann Oncol 27:908–913
Vlashi E, Chen AM, Boyrie S et al (2016) Radiation-induced dedifferentiation of head and neck cancer cells into cancer stem cells depends on human papillomavirus status. Int J Radiat Oncol Biol Phys 94:1198–1206
Wolf GT, Hong WK, Fisher SG, Urba S, Endicott JW, Fisher SR, Toohill RJ, Karp D, Miller DM, Cheung NK, Weaver A, Hillel AD, Spauldine M, Chang BK, Dougherty B, Deconti R, Garewal H, Fye C (1991) Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. The department of veterans affairs laryngeal cancer study group. N Engl J Med 324:1685–1690
Yang WF, Liao GQ, Hakim SG et al (2016) Is pilocarpine effective in preventing radiation-induced xerostomia? A systematic review and meta-analysis. Int J Radiat Oncol Biol Phys 94:503–511
Yeung AR, Garg MK, Lawson J et al (2012) ACR appropriateness criteria(r) ipsilateral radiation for squamous cell carcinoma of the tonsil. Head Neck 34:613–616
Zorlu F, Gurkaynak M, Yildiz F et al (2000) Conventional external radiotherapy in the management of clivus chordomas with overt residual disease. Neurol Sci 21:203–207
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Elliott, D.A., Nabavizadeh, N., Hiluf, K., Holland, J.M. (2017). Head and Neck Cancer. In: Lo, S., Teh, B., Jiang, GL., Mayr, N. (eds) Controversies in Radiation Oncology. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2017_47
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