Abstract
Leukemias and lymphomas comprise a diverse collection of malignancies with unique clinical behavior. Radiation therapy plays an integral role in the definitive, adjuvant, and palliative management of these hematologic malignancies. As opposed to most epithelial and mesenchymal malignancies, hematologic malignancies typically require lower doses of radiation therapy. Most can be controlled with 24–40 Gy, well within the tolerance of most normal tissues. In the palliative setting, exceptionally low doses (e.g., 4 Gy) are often sufficient. This characteristic of hematologic malignancies allows for re-treatment, when necessary, in most circumstances. In this chapter, we will review the major histologic subtypes of hematologic malignancies and discuss the settings where re-irradiation is sometimes encountered in clinical practice.
The original version of this chapter was revised. An erratum to this chapter can be found at 10.1007/978-3-319-41825-4_78.
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Abbreviations
- ABVD:
-
Doxorubicin, bleomycin, vinblastine, dacarbazine
- GHSG:
-
German Hodgkin Study Group
- ICE:
-
Ifosfamide, carboplatin, etoposide
- R-CHOP:
-
Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone
- MALT:
-
Mucosa-associated lymphoid tissue
- CNS:
-
Central nervous system
- TBI:
-
Total body irradiation
- RT:
-
Radiation therapy
- PET-CT:
-
Positron emission tomography-computed tomography
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Acknowledgment
The authors would like to thank Leonard R. Prosnitz, M.D., for his thoughtful comments that improved the quality of the chapter.
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Kelsey, C.R., Kim, G.J. (2016). Leukemia and Lymphoma. In: Nieder, C., Langendijk, J. (eds) Re-Irradiation: New Frontiers. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2016_32
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