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Gastroesophageal Reflux Disease, Globus, and Dysphagia

  • Chapter
Dysphagia

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Abstract

Gastroesophageal reflux disease (GERD) is a highly prevalent disorder in Western society and closely linked with the production of two common symptoms—dysphagia and globus pharyngeus. The interrelationship of these symptoms with GERD and with each other is complex but critical to an understanding of patients' complaints, underlying pathological mechanisms and appropriate treatment planning. In this chapter we explore these relationships, related diagnostic methodology and options for treatment of reflux disorders, dysphagia and globus.

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References

  • Allen J, Belafsky PC (2010) Endoscopic cricopharyngeal myotomy for Zenker diverticulum using the harmonic scalpel. Ear Nose Throat J 89:216–218

    PubMed  Google Scholar 

  • Allen J, White CJ, Leonard RJ, Belafsky PC (2010) Effect of cricopharyngeal muscle surgery on the pharynx. Laryngoscope 120:1498–1503

    PubMed  Google Scholar 

  • Allen J, Tinling SP, Johnston N, Belafsky P (2011) Effects of pepsin and alginate in an animal model of squamous cell carcinoma. Aliment Pharmacol Ther 33(Suppl 1):21–28

    Google Scholar 

  • Altman KW, Yu GP, Schaefer SD (2010) Consequence of dysphagia in the hospitalized patient. Impact on prognosis and hospital resources. Arch Otolaryngol Head Neck Surg 136:784–789

    PubMed  Google Scholar 

  • Ames JA, Karnell LH, Gupta AK, Coleman TC, Karnell MP, Van Daele DJ, Funk GF (2011) Outcomes after the use of gastrostomy tubes in patients whose head and neck cancer was managed with radiation therapy. Head Neck 33(5):638–644. doi:10.1002/hed.21506

    Google Scholar 

  • Arevalo LF, Sharma N, Castell DO (2011) Symptomatic non-acid reflux—the new frontier in gastro-oesophageal reflux disease. Aliment Pharmacol Ther 33(Suppl 1):29–35

    Google Scholar 

  • Aviv JE, Mohr JP, Blizter A, Thomson JE, Close LG (1997) Restoration of laryngopharyngeal sensation by neural anastomosis. Arch Otolaryngol Head Neck Surg 123:154–160

    PubMed  CAS  Google Scholar 

  • Aviv JE, Kaplan ST, Thomson JE, Spitzer J, Diamond B, Close LG (2000a) The safety of flexible endoscopic evaluation of swallowing with sensory testing (FEESST): an analysis of 500 consecutive evaluations. Dysphagia 15:39–44

    PubMed  CAS  Google Scholar 

  • Aviv JE, Liu H, Parides M, Kaplan ST, Close LG (2000b) Laryngopharyngeal sensory deficits in patients with laryngopharyngeal reflux and dysphagia. Ann Otol Rhinol Laryngol 109:1000–1006

    PubMed  CAS  Google Scholar 

  • Belafsky PC (2010) Manual control of the upper esophageal sphincter. Laryngoscope 120:S1–S16

    PubMed  Google Scholar 

  • Belafsky PC, Rees CJ (2009) Functional oesophagoscopy: endoscopic evaluation of the oesophageal phase of deglutition. J Laryngol Otol 123:1031–1034

    PubMed  CAS  Google Scholar 

  • Belafsky PC, Postma GN, Koufman JA (2002) Validity and reliability of the Reflux Symptom Index (RSI). J Voice 16:274–277

    PubMed  Google Scholar 

  • Belafsky PC, Mouadeb DA, Rees CJ, Allen JE, Leonard RJ (2008) Validity and reliability of the Eating Assessment Tool (EAT-10). Ann Otol Rhinol Laryngol 117:919–924

    PubMed  Google Scholar 

  • Borr C, Hielscher-Fastabend M, Lücking A (2007) Reliability and validity of cervical auscultation. Dysphagia 22:225–234

    PubMed  Google Scholar 

  • Bours GJ, Speyer R, Lemmens J, Limburg M, de Wit R (2009) Bedside screening tests vs videofluoroscopy or fibreoptic endoscopic evaluation of swallowing to detect dysphagia in patients with neurological disorders: systematic review. J Adv Nurs 65:477–493

    PubMed  Google Scholar 

  • Broniatowski M, Moore NZ, Grundfest-Broniatowski S, Tucker HM, Lancaster E, Krival K, Hadley AJ, Tyler DJ (2010) Paced glottic closure for controlling aspiration pneumonia in patients with neurologic deficits of various causes. Ann Otol Rhinol Laryngol 119:141–149

    PubMed  Google Scholar 

  • Caro JJ, Salas M, Ward A (2001) Healing and relapse rates in gastroesophageal reflux disease treated with the newer proton-pump inhibitors lansoprazole, rabeprazole, and pantoprazole compared with omeprazole, ranitidine, and placebo: evidence from randomized clinical trials. Clin Ther 23:998–1017

    PubMed  CAS  Google Scholar 

  • Carrau RL, Pou A, Eibling DE, Murry T, Ferguson BJ (1999) Laryngeal framework surgery for the management of aspiration. Head Neck 21:139–145

    PubMed  CAS  Google Scholar 

  • Catania RA, Kavic SM, Roth JS, Lee TH, Meyer T, Fantry GT, Castellanos PF, Park A (2007) Laparoscopic Nissen fundoplication effectively relieves symptoms in patients with laryngopharyngeal reflux. J Gastrointest Surg 11:1579–1588

    PubMed  Google Scholar 

  • Chassany O, Holtmann G, Malagelada J, Gebauer U, Doerfler H, Devault K (2008) Systematic review: health-related quality of life (HRQOL) questionnaires in gastro-oesophageal reflux disease. Aliment Pharmacol Ther 27:1053–1070

    PubMed  CAS  Google Scholar 

  • Chen AY, Frankowski R, Bishop-Leone J, Hebert T, Leyk S, Lewin J, Geopfert H (2001) The development and validation of a dysphagia-specific quality-of-life questionnaire for patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 127:870–876

    PubMed  CAS  Google Scholar 

  • Ciccaglione AF, Marzio L (2003) Effect of acute and chronic administration of the GABA B agonist baclofen on 24 hr pH metry and symptoms in controls subjects and in patients with gastroesophageal reflux disease. Gut 52:464–470

    PubMed  CAS  Google Scholar 

  • Dean BB, Gano AD Jr, Knight K, Ofman JJ, Fass R (2004) Effectiveness of proton pump inhibitors in nonerosive reflux disease. Clin Gastroenterol Hepatol 2:656–664

    PubMed  CAS  Google Scholar 

  • Del Negro A, Araújo MR, Tincani AJ, Meirelles L, Martins AS, Andreollo NA (2008) Experimental carcinogenesis on the oropharyngeal mucosa of rats with hydrochloric acid, sodium nitrate and pepsin. Acta Cir Bras 23(4):337–342

    PubMed  Google Scholar 

  • Dent J, Vakil N, Jones R, Bytzer P, Schoning U, Halling K, Junghard O, Lind T (2010) Accuracy of the diagnosis of GORD by questionnaire, physicians and a trial of proton pump inhibitor treatment: the Diamond Study. Gut 59:7114–7721

    Google Scholar 

  • Dettmar PW, Sykes J, Little SL, Bryan J (2006) Rapid onset of effect of sodium alginate on gastro-oesophageal reflux compared with ranitidine and omeprazole, and relationship between symptoms and reflux episodes. Int J Clin Pract 60:275–283

    PubMed  CAS  Google Scholar 

  • El-Serag HB, Hepworth EJ, Lee P, Sonnenberg A (2001) Gastroesophageal reflux disease is a risk factor for laryngeal and pharyngeal cancer. Am J Gastroenterol 96(7):2013–2018

    PubMed  CAS  Google Scholar 

  • Farley A, Wruble LD, Humphries TJ (2000) Rabeprazole versus ranitidine for the treatment of erosive gastroesophageal reflux disease: a double-blind, randomized clinical trial. Rabeprazole Study Group. Am J Gastroenterol 95:1894–1899

    PubMed  CAS  Google Scholar 

  • Farri A, Accornero A, Burdese C (2007) Social importance of dysphagia: its impact on diagnosis and therapy. Acta Otorhinolaryngol Ital 27:83–86

    PubMed  CAS  Google Scholar 

  • Fox M (2011) Identifying the causes of reflux events and symptoms—new approaches. Aliment Pharmacol Ther 33(Suppl 1):36–42

    Google Scholar 

  • Francis DO, Maynard C, Weymuller EA, Reiber G, Merati AL, Yueh B (2011) Reevaluation of gastroesophageal reflux disease as a risk factor for laryngeal cancer. Laryngoscope 121:102–105

    PubMed  Google Scholar 

  • Frye JW, Vaezi MF (2008) Extraesophageal GERD. Gastroenterol Clin North Am 37:845–858

    PubMed  Google Scholar 

  • Fujimoto Y, Hasegawa Y, Yamada H, Ando A, Nakashima T (2007) Swallowing function following extensive resection of oral or oropharyngeal cancer with laryngeal suspension and cricopharyngeal myotomy. Laryngoscope 117:1343–1348

    PubMed  Google Scholar 

  • Furuta GT, Liacouras CA, Collins MH, Gupta SK, Justinich C, Putnam PE, Bonis P, Hassall E, Straumann A, Rothenberg ME, (FIGERS) subcommittee (2007) Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology 133:1342–1363

    PubMed  CAS  Google Scholar 

  • Galli J, Cammarota G, Calò L, Agostino S, D’Ugo D, Cianci R, Almadori G (2002) The role of acid and alkaline reflux in laryngeal squamous cell carcinoma. Laryngoscope 112:1861–1865

    PubMed  CAS  Google Scholar 

  • Gill G, Johnston N, Buda A, Pignatelli M, Pearson J, Dettmar P, Koufman J (2005) Laryngeal epithelial defenses against laryngopharyngeal reflux: investigation of E-cadherin, carbonic anhydrase isoenzyme III, and pepsin. Ann Otol Rhinol Laryngol 114:913–921

    PubMed  Google Scholar 

  • Gisbert JP, Cooper A, Karagiannis D, Hatlebakk J, Agréus L, Jablonowski H, Zapardiel J (2009) Impact of gastroesophageal reflux disease on patients’ daily lives: a European observational study in the primary care setting. Health Qual Life Outcomes 7:60

    PubMed  Google Scholar 

  • Gold BD (2004) Epidemiology and management of gastroesophageal reflux in children. Aliment Pharmacol Ther 19(Suppl 1):22–27

    PubMed  Google Scholar 

  • He J, Ma X, Zhao Y, Wang R, Yan X, Yan H, Yin P, Kang X, Fang J, Hao Y, Dent J, Sung JJY, Wallander MA, Johansson S, Liu W, Li Z (2010) A population-based survey of the epidemiology of symptom-defined gastroesophageal reflux disease: the Systematic Investigation of Gastrointestinal disease in China. BMC Gastroenterol 10:94

    PubMed  Google Scholar 

  • Hendricker RM, deSilva BW, Forrest LA (2010) Gore-Tex medialization laryngoplasty for treatment of dysphagia. Otolaryngol Head Neck Surg 142:536–539

    PubMed  Google Scholar 

  • Herrmann IF (1992) Surgical solutions for aspiration problems. J Jpn Bronchoesophageal Soc 43:72–79

    Google Scholar 

  • Hurtado CW, Furuta GT, Kramer RE (2011) Etiology of esophageal food impaction in children. J Pediatr Gastroenterol Nutr 52:43–46

    PubMed  Google Scholar 

  • Johnston N, Bulmer D, Gill G, Panetti M, Ross P, Pearson J, Pignatelli M, Axford S, Dettmar P, Koufman J (2003) Cell biology of laryngeal epithelial defenses in healthy and disease: further studies. Ann Otol Rhinol Laryngol 112:481–491

    PubMed  Google Scholar 

  • Johnston N, Knight J, Dettmar P, Lively M, Koufman J (2004a) Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease. Laryngoscope 114:2129–2134

    PubMed  CAS  Google Scholar 

  • Johnston N, Knight J, Dettmar PW, Lively MO, Koufman J (2004b) Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease. Laryngoscope 114(12):2129–2134

    PubMed  CAS  Google Scholar 

  • Johnston N, Dettmar PW, Lively MO, Postma GN, Belafsky PC, Birchall M, Koufman JA (2006) Effect of pepsin on laryngeal stress protein (Sep70, Sep53, and Hsp70) response: role in laryngopharyngeal reflux disease. Ann Otol Rhinol Laryngol 115(1):47–58

    PubMed  Google Scholar 

  • Johnston N, Wells CW, Blumin JH, Toohill RJ, Merati AL (2007) Receptor-mediated uptake of pepsin by laryngeal epithelial cells. Ann Otol Rhinol Laryngol 116(12):934–938

    PubMed  Google Scholar 

  • Jones R, Coyne K, Wiklund I (2007) The Gastro-oesophageal Reflux Disease Impact Scale: a patient management tool for primary care. Aliment Pharmacol Ther 25:1451–1459

    PubMed  CAS  Google Scholar 

  • Kanakala V, Lamb CA, Haigh C, Stirling RW, Attwood SE (2010) The diagnosis of primary eosinophilic esophagitis in adults: missed or misinterpreted? Eur J Gastroenterol Hepatol 22:848–855

    PubMed  Google Scholar 

  • Kinekawa F, Kubo F, Matsuda K, Kobayashi M, Furuta Y, Fujita Y, Okada H, Muraoka T, Yamanouchi H, Inoue H, Uchida Y, Masaki T (2008) Esophageal function worsens with long duration of diabetes. J Gastroenterol 43:338–344

    PubMed  Google Scholar 

  • Knight J, Lively MO, Johnston N, Dettmar PW, Koufman JA (2005) Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux. Laryngoscope 115(8):1473–1478

    PubMed  CAS  Google Scholar 

  • Koek GH, Sifrim D, Lerut T, Janssens J, Tack J (2003) Effect of the GABA(B) agonist baclofen in patients with symptoms and duodeno-gastro-oesophageal reflux refractory to proton pump inhibitors. Gut 52:1397–1402

    PubMed  CAS  Google Scholar 

  • Kos MP, David EF, Klinkenberg-Knol EC, Mahieu HF (2010) Long-term results of external upper esophageal sphincter myotomy for oropharyngeal dysphagia. Dysphagia 25:169–176

    PubMed  Google Scholar 

  • Kotby MN, Hassan O, El-Makhzangy AMN, Farahat M, Shadi M, Milad P (2010) Gastroesophageal reflux/laryngopharyngeal reflux disease: a critical analysis of the literature. Eur Arch Otorhinolaryngol 267:171–179

    PubMed  CAS  Google Scholar 

  • Koufman J (1991) The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): A clinical investigation of 225 patients using ambulatory 24-hr pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope 101(Suppl 53):1–78

    PubMed  CAS  Google Scholar 

  • Koufman JA (2002) Prevalence of esophagitis in patients with pH-documented laryngopharyngeal reflux. Laryngoscope 112:1606–1609

    PubMed  CAS  Google Scholar 

  • Ku PK, Abdullah VF, Vlantis AC, Lee KY, van Hasselt AC, Tong MC (2009) ‘Steam-boat’ supraglottic laryngoplasty for treatment of chronic refractory aspiration: a modification of Biller’s technique. J Laryngol Otol 123:1360–1363

    PubMed  CAS  Google Scholar 

  • Lacy B, Weiser K, Chertoff J, Fass R, Pandolfino JE, Richter JE, Rothstein RI, Spangler C, Vaezi MF (2010) The diagnosis of gastroesophageal reflux disease. Am J Med 123:583–592

    PubMed  Google Scholar 

  • Lang IM, Medda BK, Shaker R (2001) Mechanisms of reflexes induced by esophageal distension. Am J Physiol Gastrointest Liver Physiol 281:G1246–G1263

    PubMed  CAS  Google Scholar 

  • Langmore SE (2003) Evaluation of oropharyngeal dysphagia: which diagnostic tool is superior? Curr Opin Otolaryngol Head Neck Surg 11:485–489

    PubMed  Google Scholar 

  • Langmore SE, Schatz K, Olson N (1991) Endoscopic and videofluoroscopic evaluations of swallowing and aspiration. Ann Otol Rhinol Laryngol 100:678–681

    PubMed  CAS  Google Scholar 

  • Lawson G, Remacle M, Jamart J, Keghian J (2003) Endoscopic CO2 laser-assisted surgery for cricopharyngeal dysfunction. Eur Arch Otorhinolaryngol 260:475–480

    PubMed  Google Scholar 

  • Leslie P, Drinnan MJ, Finn P, Ford GA, Wilson JA (2004) Reliability and validity of cervical auscultation: a controlled comparison using videofluoroscopy. Dysphagia 19:231–240

    PubMed  Google Scholar 

  • Lewin J, Gillenwater A, Garrett J, Bishop-Leone J, Nguyen D, Callender D, Ayers G, Myers J (2003) Characterization of laryngopharyngeal reflux in patients with premalignant and early carcinomas of the larynx. Cancer 97:1010–1014

    PubMed  Google Scholar 

  • Lien HC, Wang CC, Hsu JY, Sung FC, Cheng KF, Liang WM, Kuo HW, Lin PH, Chang CS (2010) Classical reflux symptoms, hiatal hernia and overweight independently predict pharyngeal acid exposure in patients with suspected reflux laryngitis. Aliment Pharmacol Ther. doi:10.1111/j.1365-2036.2010.04502.x

  • Lim KB, Lee HJ, Lim SS, Choi YI (2009) Neuromuscular electrical and thermal-tactile stimulation for dysphagia caused by stroke: a randomized controlled trial. J Rehabil Med 41:174–178

    PubMed  Google Scholar 

  • Lin PH, Hsiao TY, Chang YC, Ting LL, Chen WS, Chen SC, Wang TG (2011) Effects of functional electrical stimulation on dysphagia caused by radiation therapy in patients with nasopharyngeal cancer. Support Care Cancer 19:91–99

    PubMed  Google Scholar 

  • Lindstrom D, Wallace J, Loehrl T, Merati A, Toohill R (2002) Nissen fundoplication surgery for extraesophageal manifestation of gastroesophageal reflux (EER). Laryngoscope 112:1762–1765

    PubMed  CAS  Google Scholar 

  • Little F, Koufman J, Kohut R, Marshall R (1985) Effect of gastric acid on the pathogenesis of subglottic stenosis. Ann Otol Rhinol Laryngol 94:516–519

    PubMed  CAS  Google Scholar 

  • Louis E, Tack J, Vandenhoven G, Taeter C (2009) Evaluation of the GERD Impact Scale, an international, validated patient questionnaire, in daily practice. Results of the ALEGRIA study. Acta Gastroenterol Belg 72:3–8

    PubMed  CAS  Google Scholar 

  • Lowell SY, Poletto CJ, Knorr-Chung BR, Reynolds RC, Simonyan K, Ludlow CL (2008) Sensory stimulation activates both motor and sensory components of the swallowing system. Neuroimage 42:285–295

    PubMed  Google Scholar 

  • Ludlow CL (2010) Electrical neuromuscular stimulation in dysphagia: current status. Curr Opin Otolaryngol Head Neck Surg 18:159–164

    PubMed  Google Scholar 

  • Luostarinen M (1993) Nissen fundoplication for reflux esophagitis Long-term clinical and endoscopic results of 109 of 127 consecutive patients. Ann Surg 217:329–337

    PubMed  CAS  Google Scholar 

  • Mainie I, Tutuian R, Shay S, Vela M, Zhang X, Sifrim D, Castell DO (2006a) Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedence-pH monitoring. Gut 55:1398

    PubMed  CAS  Google Scholar 

  • Mainie I, Tutuian R, Agrawal A, Adams D, Castell DO (2006b) Combined multichannel intraluminal impedence-pH monitoring to select patients with persistent gastro-oesophageal reflux for laparoscopic Nissen fundoplication. Br J Surg 93:1483

    PubMed  CAS  Google Scholar 

  • Maronian N, Azadeh H, Waugh P, Hillel A (2001) Association of laryngopharyngeal reflux disease and subglottic stenosis. Ann Otol Rhinol Laryngol 110:606–612

    PubMed  CAS  Google Scholar 

  • McCoul ED, Goldstein NA, Koliskor B, Weedon J, Jackson A, Goldsmith AJ (2011) A prospective study of the effect of gastroesophageal reflux disease treatment on children with otitis media. Arch Otolaryngol Head Neck Surg 137:35–41

    PubMed  Google Scholar 

  • McGlashan JA, Johnstone LM, Sykes J, Strugala V, Dettmar PW (2009) The value of liquid alginate suspension (Gaviscon Advance) in the management of laryngopharyngeal reflux. Arch Otorhinolaryngol 266:243–251

    Google Scholar 

  • McHorney CA, Bricker DE, Kramer AE, Rosenbek JC, Robbins J, Chignell KA, Logemann JA, Clarke C (2000a) The SWAL-QOL outcomes tool for oropharyngeal dysphagia in adults: I. Conceptual foundation and item development. Dysphagia 15:115–121

    PubMed  CAS  Google Scholar 

  • McHorney CA, Bricker DE, Robbins J, Kramer AE, Rosenbek JC, Chignell KA (2000b) The SWAL-QOL outcomes tool for oropharyngeal dysphagia in adults: II. Item reduction and preliminary scaling. Dysphagia 15:122–133

    PubMed  CAS  Google Scholar 

  • McHorney CA, Robbins J, Lomax K, Rosenbek JC, Chignell KA, Kramer AE, Bricker DE (2002) The SWAL-QOL and SWAL-CARE outcomes tool for oropharyngeal dysphagia in adults: III. Documentation of reliability and validity. Dysphagia 17:97–114

    PubMed  Google Scholar 

  • McHorney CA, Martin-Harris B, Robbins J, Rosenbek JC (2006) Clinical validity of the SWAL-QOL and SWAL-CARE outcomes tool with respect to bolus flow measure. Dysphagia 21:141–148

    PubMed  Google Scholar 

  • Meneghelli UG, Boaventura S, Moraes-Filho JP, Leitão O, Ferrari AP, Almeida JR, Magalhães AF, Castro LP, Haddad MT, Tolentino M, Jorge JL, Silva E, Maguilnik I, Fischer R (2002) Efficacy and tolerability of pantoprazole versus ranitidine in the treatment of reflux esophagitis and the influence of Helicobacter pylori infection on healing rate. Dis Esophagus 15:50–56

    PubMed  CAS  Google Scholar 

  • Meng NH, Wang TG, Lien IN (2000) Dysphagia in patients with brainstem stroke: incidence and outcome. Am J Phys Med Rehabil 79:170–175

    PubMed  CAS  Google Scholar 

  • Merati A, Lim H, Ulualp S, Toohill R (2005) Meta-analysis of upper probe measurements in normal subjects and patients with laryngopharyngeal reflux. Ann Otol Rhinol Laryngol 114:177–182

    PubMed  Google Scholar 

  • Meurmann Y (1957) Suspension of the larynx with fascial strips on the hyoid bone for removal of deglutition disorders after trauma [in German]. Arch Ohren Nasen Kehlkopfbeilkd 172:96–104

    Google Scholar 

  • Musser J, Kelchner L, Neils-Strunjas J, Montrose M (2011) A comparison of rating scales used in the diagnosis of extraesophageal reflux. J Voice 25(3):293–300

    Google Scholar 

  • Nguyen NP, Moltz CC, Frank C, Vos P, Smith HJ, Karlsson U, Dutta S, Midyett FA, Barloon J, Sallah S (2004) Dysphagia following chemoradiation for locally advanced head and neck cancer. Ann Oncol 15:383–388

    PubMed  CAS  Google Scholar 

  • Nguyen NP, Frank C, Moltz CC, Vos P, Smith HJ, Bhamidipati PV, Karlsson U, Nguyen PD, Alfieri A, Nguyen LM, Lemanski C, Chan W, Rose S, Sallah S (2006) Aspiration rate following chemoradiation for head and neck cancer: an underreported occurrence. Radiother Oncol 80:302–306

    PubMed  Google Scholar 

  • Nocon M, Labenz J, Jaspersen D, Leodolter A, Richter K, Vieth M, Lind T, Malfertheiner P, Willich SN (2008) Health-related quality of life in patients with gastro-oesophageal reflux disease under routine care: 5-year follow-up results of the ProGERD study. Aliment Pharmacol Ther 29:662–668

    Google Scholar 

  • Noordzij J, Khidr A, Evans B, Desper E, Mittal R, Reibel J, Levine P (2001) Evaluation of omeprazole in the treatment of reflux laryngitis: a prospective, placebo-controlled, randomized, double-blind study. Laryngoscope 111:2147–2151

    PubMed  CAS  Google Scholar 

  • Numans ME, Lau J, de Wit NJ, Bonis PA (2004) Short-term treatment with proton-pump inhibitors as a test for gastroesophageal reflux disease. Ann Intern Med 140:518–527

    PubMed  CAS  Google Scholar 

  • Orlando RC (2011) Oesophageal tissue damage and protection. Aliment Pharmacol Ther 33(Suppl 1):8–12

    CAS  Google Scholar 

  • Ozgursoy OB, Salassa JR (2010) Manofluorographic and functional outcomes after endoscopic laser cricopharyngeal myotomy for cricopharyngeal bar. Otolaryngol Head Neck Surg 142:735–740

    PubMed  Google Scholar 

  • Ozulgedik S, Yorulmaz I, Gokcan K (2006) Is laryngopharyngeal reflux an important risk factor in the development of laryngeal carcinoma? Eur Arch Otorhinolaryngol 263:339–343

    Google Scholar 

  • Park W, Hicks DM, Khandwala F, Richter JE, Abelson TI, Milstein C, Vaezi MF (2005) Laryngopharyngeal reflux: prospective cohort study evaluating optimal dose of proton-pump inhibitor therapy and pretherapy predictors of response. Laryngoscope 115:1230–1238

    PubMed  CAS  Google Scholar 

  • Park S, Chun HJ, Keum B, Uhm CS, Baek SK, Jung KY, Lee SJ (2010) An electron microscopic study—correlation of gastroesophageal reflux disease and laryngopharyngeal reflux. Laryngoscope 120:1303–1308

    PubMed  Google Scholar 

  • Pearson JP, Parikh S (2011) Nature and properties of gastro-oesophageal and extra-oesophageal refluxate. Aliment Pharmacol Ther 33(Suppl 1):2–7

    CAS  Google Scholar 

  • Peng S, Xiong LS, Xiao YL, Lin JK, Wang AJ, Zhang N, Hu PJ, Chen MH (2010) Prompt upper endoscopy is an appropriate initial management in uninvestigated Chinese patients with typical reflux symptoms. Am J Gastroenterol 105:1947–1952

    PubMed  Google Scholar 

  • Peponi E, Glanzmann C, Willi B, Huber G, Studer G (2011) Dysphagia in head and neck cancer patients following intensity modulated radiotherapy (IMRT). Rad Oncol 6:1

    Google Scholar 

  • Pitman M, Weissbrod P (2009) Endoscopic CO2 laser cricopharyngeal myotomy. Laryngoscope 119:45–53

    PubMed  Google Scholar 

  • Postma G (2000) Ambulatory pH monitoring methodology. Ann Otol Rhinol Laryngol 109:10–14

    Google Scholar 

  • Postma G, Johnson L, Koufman J (2002) Treatment of laryngopharyngeal reflux. Ear Nose Throat J 81(Suppl 2):24–26

    PubMed  Google Scholar 

  • Postma G, Cohen J, Belafsky P, Halum S, Gupta S, Bach K, Koufman J (2005) Transnasal esophagoscopy: revisited (over 700 consecutive cases). Laryngoscope 115:321–323

    PubMed  Google Scholar 

  • Prasad GH, Alexander JA, Schleck CD, Zinsmeister AR, Smyrk TC, Elias RM, Locke GR 3rd, Talley NJ (2009) Epidemiology of eosinophilic esophagitis over three decades in Olmstead County, Minnesota. Clin Gastroenterol Hepatol 7:1055–1061

    PubMed  Google Scholar 

  • Qadeer MA, Swoger J, Milstein C, Hicks DM, Ponsky J, Richter JE, Abelson TI, Vaezi MF (2005) Correlation between symptoms and laryngeal signs in laryngopharyngeal reflux. Laryngoscope 115:1947–1952

    PubMed  Google Scholar 

  • Qadeer MA, Phillips CO, Lopez AR, Steward DL, Noordzij JP, Wo JM, Suurna M, Havas T, Howden CW, Vaezi MF (2006) Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis: a meta-analysis of randomized controlled trials. Am J Gastroenterol 101:2646–2654

    PubMed  CAS  Google Scholar 

  • Ramsey DJC, Smithard DG, Kalra L (2003) Early assessments of dysphagia and aspiration risk in acute stroke patients. Stroke 34:1252–1257

    PubMed  Google Scholar 

  • Rees C (2007) In-office transnasal esophagoscope-guided botulinum toxin injection of the lower esophageal sphincter. Curr Opin Otolaryngol Head Neck Surg 15:409–411

    PubMed  Google Scholar 

  • Rees CJ, Belafsky PC (2008) Laryngopharyngeal reflux: current concepts in pathophysiology, diagnosis, and treatment. Int J Speech Lang Pathol 10:245–253

    PubMed  Google Scholar 

  • Reimer C, Søndergaard B, Hilsted L, Bytzer P (2009) Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy. Gastroenterology 137:80–87

    PubMed  CAS  Google Scholar 

  • Ricker J, McNear S, Cassidy T, Plott E, Arnold H, Kendall B, Franklin K (2011) Routine screening for eosinophilic esophagitis in patients presenting with dysphagia. Ther Adv Gastroenterol 4:27–35

    Google Scholar 

  • Robbins J, Langmore S, Hinds JA, Erlichman M (2002) Dysphagia research in the 21st century and beyond: proceedings from Dysphagia Experts Meeting, August 21, 2001. J Rehabil Res Dev 39:543–548

    PubMed  Google Scholar 

  • Ronkainen J, Aro P, Storskrubb T, Lind T, Bolling-Sternevald E, Junghard O, Talley NJ, Agreus L (2006) Gastro-oesophageal reflux symptoms and health-related quality of life in the adult general population—the Kalixanda study. Aliment Pharmacol Ther 23:1725–1733

    PubMed  CAS  Google Scholar 

  • Ryu JS, Kang JY, Park JY, Nam SY, Choi SH, Roh JL, Kim SY, Choi KH (2009) The effect of electrical stimulation therapy on dysphagia following treatment for head and neck cancer. Oral Oncol 45:665–668

    PubMed  Google Scholar 

  • Samuels TL, Johnston N (2009) Pepsin as a causal agent of inflammation during nonacidic reflux. Otolaryngol Head Neck Surg 141(5):559–563

    PubMed  Google Scholar 

  • Samuels TL, Handler E, Syring ML, Pajewski NM, Blumin JH, Kerschner JE, Johnston N (2008) Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux. Ann Otol Rhinol Laryngol 117(9):688–695

    PubMed  Google Scholar 

  • Schroeder PL, Richter JE (1994) Swallowing disorders in the elderly. Semin Gastrointest Dis 5:154–165

    PubMed  CAS  Google Scholar 

  • Sealock RJ, Rendon G, El-Serag HB (2010) Systematic review: the epidemiology of eosinophilic esophagitis in adults. Aliment Pharm Ther 32:712–719

    CAS  Google Scholar 

  • Shaw MJ, Talley NJ, Beebe TJ, Rockwood T, Carlsson R, Adlis S, Fendrick M, Jones R, Dent J, Bytzer P (2001) Initial validation of a diagnostic questionnaire for gastroesophageal reflux disease. Am J Gastroenterol 96:52–57

    PubMed  CAS  Google Scholar 

  • Shaw M, Dent J, Beebe T, Junghard O, Wiklund I, Lind T, Johnsson F (2008) The Reflux Disease Questionnaire: a measure for assessment of treatment response in clinical trials. Health Qual Life Outcomes 6:31

    PubMed  Google Scholar 

  • Shaw JM, Barnman PC, Callanan MD, Beckingham IJ, Metz DC (2010) Long-term outcome of laparoscopic Nissen and laparoscopic Toupet fundoplication for gastroesophageal reflux disease: a prospective, randomized trial. Surg Endosc 24:924–932

    PubMed  Google Scholar 

  • Smith DF, Ott DJ, Gelfand DW, Chen MYM (1998) Lower esophageal mucosal ring: correlation of referred symptoms with radiologic findings using a marshmallow bolus. Am J Roentgenol 171:1361–1365

    CAS  Google Scholar 

  • Steward D, Wilson K, Kelly D, Patil M, Schwartzbauer H, Long D, Welge J (2004) Proton pump inhibitor therapy for chronic laryngo-pharyngitis: a randomized placebo control trial. Otolaryngol Head Neck Surg 131:342–350

    PubMed  Google Scholar 

  • Strugala V, Avis J, Jolliffe IG, Johnstone LM, Dettmar PW (2009) The role of an alginate suspension on pepsin and bile acids—key aggressors in the gastric refluxate Does this have implications for the treatment of gastro-oesophageal reflux disease? J Pharm Pharmacol 61:1021–1028

    PubMed  CAS  Google Scholar 

  • Swoger J, Ponsky J, Hicks DM, Richter JE, Abelson TI, Milstein C, Qadeer MA, Vaezi MF (2006) Surgical fundoplication in laryngopharyngeal reflux unresponsive to aggressive acid suppression: a controlled study. Clin Gastroenterol Hepatol 4:433–441

    PubMed  Google Scholar 

  • Szczesniak MM, William RBH, Brake HM, Maclean JC, Cole IE, Cook IJ (2010) Upregulation of the esophago-UES relaxation response: a possible pathophysiological mechanism in suspected reflux laryngitis. Neurogastroenterol Motil 22:381–389

    PubMed  CAS  Google Scholar 

  • Tack J (2005) Role of pepsin and bile in gastro-oesophageal reflux disease. Ali Pharmacol Ther 22(Suppl 1):48–54

    CAS  Google Scholar 

  • Tang M, Dettmar P, Batchelor H (2005) Bioadhesive oesophageal bandages: protection against acid and pepsin injury. Int J Pharmaceutics 292:169–177

    CAS  Google Scholar 

  • Tasker A, Dettmar PW, Panetti M, Koufman JA, Birchall J, Pearson JP (2002) Is gastric reflux a cause of otitis media with effusion in children? Laryngoscope 112:1930–1934

    PubMed  Google Scholar 

  • Tauber S, Gross M, Issing WJ (2002) Association of laryngopharyngeal symptoms with gastroesophageal reflux disease. Laryngoscope 112:879–886

    PubMed  Google Scholar 

  • Tutuian R (2011) Obesity and GERD: pathophysiology and effect of bariatric surgery. Curr Gastroenterol Rep. doi:10.1007/s11894-011-0191-y

  • Vaezi MF, Qadeer MA, Lopez R, Colabianchi N (2006) Laryngeal cancer and gastroesophageal reflux disease: a case-control study. Am J Med 119:768–776

    PubMed  Google Scholar 

  • Vakil NB, Traxler B, Levine D (2004) Dysphagia in patients with erosive esophagitis: prevalence, severity, and response to proton pump inhibitor treatment. Clin Gastroenterol Hepatol 2(8):665–668

    PubMed  CAS  Google Scholar 

  • Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R, Global consensus group (2006) The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 101:1900–1920

    PubMed  Google Scholar 

  • Wada T, Sasaki M, Kataoka H, Ogasawara N, Kanematsu T, Tanida S, Nojiri S, Ando T, Okochi M, Joh T (2009) Gastroesophageal and laryngopharyngeal reflux symptoms correlate with histopathologic inflammation of the upper and lower esophagus. J Clin Gastroenterol 43:249–252

    PubMed  Google Scholar 

  • Wang X, Pitchumoni CS, Chandrarana K, Shah N (2008) Increased prevalence of symptoms of gastroesophageal reflux diseases in type 2 diabetics with neuropathy. World J Gastroenterol 14:709–712

    PubMed  Google Scholar 

  • Westcott C, Hopkins B, Bach K, Postma G, Belafsky P, Koufman J (2004) Fundoplication for laryngopharyngeal reflux disease. J Am Coll Surg 199:23–30

    PubMed  Google Scholar 

  • Wight R, Paleri V, Arullendram P (2003) Current theories for the development of nonsmoking and nondrinking laryngeal carcinoma. Curr Opin Otolaryngol Head Neck Surg 11:73–77

    PubMed  Google Scholar 

  • Wilson JA (2005) What is the evidence that gastro-oesophageal reflux is involved in the aetiology of laryngeal cancer? Curr Opin Otolaryngol Head Neck Surg 12:97–100

    Google Scholar 

  • Wirth D, Kern B, Guenin MO, Montal I, Peterli R, Ackermann C, von Flue M (2006) Outcome and quality of life after open surgery versus endoscopic stapler-assisted esophagodiverticulostomy for Zenker’s diverticulum. Dis Esophagus 19:294–298

    PubMed  CAS  Google Scholar 

  • Woodson G (1997) Cricopharyngeal myotomy and arytenoid adduction in the management of combined laryngeal and pharyngeal paralysis. Otolaryngol Head Neck Surg 116:339–343

    PubMed  CAS  Google Scholar 

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Appendix

Appendix

Table A.1 Ten-item Eating Assessment Tool (EAT-10) (Belafsky et al. 2008)

Reflux Disease Questionnaire (RDQ) (Shaw et al. 2001)

Three domains (heartburn, regurgitation, dyspepsia)

  • Acid taste frequency

  • Acid taste severity

  • Movement of materials severity

  • Movement of materials frequency

  • Frequency of pain behind the breastbone

  • Frequency of burning behind the breastbone

  • Severity of burning behind the breastbone

  • Severity of pain behind the breastbone

  • Upper stomach burning severity

  • Upper stomach burning frequency

  • Upper stomach pain frequency

  • Upper stomach pain severity

Gastro-oesophageal Reflux Disease Impact Scale (GIS) (Jones et al. 2007)

Subjects make one of four responses—daily, often, sometimes, or never:

  1. 1.

    How often have you had the following symptoms:

    • Pain in your chest or behind the breastbone?

    • Regurgitation or acid taste in your mouth?

    • Pain or burning in your upper stomach?

    • Sore throat or hoarseness that is related to your heartburn or acid reflux?

  2. 2.

    How often have you had difficulty getting a good night’s sleep because of your symptoms?

  3. 3.

    How often have your symptoms prevented you from eating or drinking any of the foods you like?

  4. 4.

    How frequently have your symptoms kept you from being fully productive in your job or daily activities?

  5. 5.

    How often do you take additional medication other than what the physician told you to take (such as Tums, Rolaids, Maalox)?

Table A.2 Reflux Symptom Index (RSI) (Belafsky et al. 2002)

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Allen, J., Belafsky, P.C. (2011). Gastroesophageal Reflux Disease, Globus, and Dysphagia. In: Ekberg, O. (eds) Dysphagia. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2011_340

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