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Eye Tumors

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Re-irradiation: New Frontiers

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

The question of re-irradiating the eye after ocular radiation is rarely raised, since the eye is irradiated infrequently as a primary target. Rather, significant efforts are made to minimize the dose received incidentally by the eye during treatment of tumors of the orbit or peri-orbital areas, or of other head and neck or central nervous system sites. CT-based 3D treatment planning is essential for treating these sites, and the eye itself, since availability of archived dosimetry data regarding previously administered irradiation is invaluable when considering re-irradiation of the eye, or of new or recurrent tumors involving the orbit or other adjacent sites. This chapter will discuss the need for radiation oncologists to be aware of the differing threshold doses for complications involving various parts of the eye, specifically the lens, optic nerve, macula, and retina, as well as the tolerance of the lacrimal gland and the tear-producing cells in the eyelids. Recommendations are provided for determining the advisability of attempting re-irradiation of the eye after primary treatment with low, intermediate, or high doses. Advantages of focused radiation therapy techniques, specifically external beam proton therapy and episcleral radionuclide plaque brachytherapy for primary treatment or for re-irradiation of discrete ocular tumors are discussed. Finally, results of two retrospective studies of proton beam re-irradiation of ocular melanomas are described.

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Authors and Affiliations

  1. Department of Radiation Oncology, Cox 802, Massachusetts General Hospital, Boston, MA, 02114, USA

    John E. Munzenrider

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  1. John E. Munzenrider
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Correspondence to John E. Munzenrider .

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Editors and Affiliations

  1. , Dept. Internal Medicine, Nordlandssykehuset HF, Prinsensgate 164, Bodoe, 8092, Norway

    Carsten Nieder

  2. Department of Radiation Oncology, University Medical Center Groningen, Hanzeplein 1, Groningen, 9700 RB, Netherlands

    Johannes A. Langendijk

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© 2011 Springer-Verlag Berlin Heidelberg

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Munzenrider, J.E. (2011). Eye Tumors. In: Nieder, C., Langendijk, J. (eds) Re-irradiation: New Frontiers. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2010_107

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  • DOI: https://doi.org/10.1007/174_2010_107

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-12467-9

  • Online ISBN: 978-3-642-12468-6

  • eBook Packages: MedicineMedicine (R0)

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