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ADP-Ribosylation and Cross-Linking of Actin by Bacterial Protein Toxins

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The Actin Cytoskeleton

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 235))

Abstract

Actin and the actin cytoskeleton play fundamental roles in host–pathogen interactions. Proper function of the actin cytoskeleton is crucial for innate and acquired immune defense. Bacterial toxins attack the actin cytoskeleton by targeting regulators of actin. Moreover, actin is directly modified by various bacterial protein toxins and effectors, which cause ADP-ribosylation or cross-linking of actin. Modification of actin can result in inhibition or stimulation of actin polymerization. Toxins, acting directly on actin, are reviewed.

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Notes

  1. 1.

    ®In the following both types of bacterial virulence factors will be assigned as “toxins.”

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Authors and Affiliations

  1. Institute for Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs-Universität Freiburg, Freiburg, 79104, Germany

    Klaus Aktories, Carsten Schwan & Alexander E. Lang

  2. Freiburg Institute of Advanced Studies (FRIAS), Albert-Ludwigs-Universität Freiburg, Freiburg, 79104, Germany

    Klaus Aktories

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  1. Klaus Aktories
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  2. Carsten Schwan
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Correspondence to Klaus Aktories .

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  1. Cell Biology, Life Sciences, BRICS, TU Braunschweig, Braunschweig, Germany

    Brigitte M. Jockusch

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Aktories, K., Schwan, C., Lang, A.E. (2016). ADP-Ribosylation and Cross-Linking of Actin by Bacterial Protein Toxins. In: Jockusch, B. (eds) The Actin Cytoskeleton. Handbook of Experimental Pharmacology, vol 235. Springer, Cham. https://doi.org/10.1007/164_2016_26

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